diphenylpyraline-2205 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the diphenylpyraline-2205 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADGRL3 adhesion G protein-coupled receptor L3
ADORA1 adenosine A1 receptor
AGXT alanine-glyoxylate aminotransferase
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
APOE apolipoprotein E
ATP9B ATPase, class II, type 9B
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BMP7 bone morphogenetic protein 7
BTNL3 butyrophilin-like 3
CA5A carbonic anhydrase VA, mitochondrial
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCND1 cyclin D1
CD6 CD6 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHPF chondroitin polymerizing factor
CIZ1 CDKN1A interacting zinc finger protein 1
CNN1 calponin 1, basic, smooth muscle
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPEB3 cytoplasmic polyadenylation element binding protein 3
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNS cystinosin, lysosomal cystine transporter
DCSTAMP dendrocyte expressed seven transmembrane protein
DEFA4 defensin, alpha 4, corticostatin
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DMC1 DNA meiotic recombinase 1
DNAH17 dynein, axonemal, heavy chain 17
DOC2B double C2-like domains, beta
DOPEY2 dopey family member 2
DRD2 dopamine receptor D2
EDNRA endothelin receptor type A
EMID1 EMI domain containing 1
FAM76A family with sequence similarity 76, member A
FAM86C1 family with sequence similarity 86, member C1
FNDC8 fibronectin type III domain containing 8
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GRM1 glutamate receptor, metabotropic 1
GSN gelsolin
GUK1 guanylate kinase 1
HAS2 hyaluronan synthase 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ICAM5 intercellular adhesion molecule 5, telencephalin
INPP5K inositol polyphosphate-5-phosphatase K
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JAG1 jagged 1
LINC00652 long intergenic non-protein coding RNA 652
MAP7 microtubule-associated protein 7
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MED27 mediator complex subunit 27
MNMIP1 manchette microtubule inner protein 1
MR1 major histocompatibility complex, class I-related
MVP major vault protein
NECAB2 N-terminal EF-hand calcium binding protein 2
NES nestin
NRG2 neuregulin 2
NUP188 nucleoporin 188kDa
OLFM1 olfactomedin 1
ONECUT1 one cut homeobox 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PDZK1IP1 PDZK1 interacting protein 1
PICALM phosphatidylinositol binding clathrin assembly protein
PLD3 phospholipase D family, member 3
PPARA peroxisome proliferator-activated receptor alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PYGB phosphorylase, glycogen; brain
QPCTL glutaminyl-peptide cyclotransferase-like
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASAL1 RAS protein activator like 1 (GAP1 like)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RDX radixin
REC8 REC8 meiotic recombination protein
RELN reelin
RGS5 regulator of G-protein signaling 5
SEZ6L seizure related 6 homolog (mouse)-like
SH2D4A SH2 domain containing 4A
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SORBS3 sorbin and SH3 domain containing 3
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRPX sushi-repeat containing protein, X-linked
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STARD13 StAR-related lipid transfer (START) domain containing 13
STK24 serine/threonine kinase 24
TACR1 tachykinin receptor 1
TEX40 testis expressed 40
TFF2 trefoil factor 2
THAP10 THAP domain containing 10
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TP63 tumor protein p63
TRPC3 transient receptor potential cation channel, subfamily C, member 3
YIPF2 Yip1 domain family, member 2

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADGRG2 adhesion G protein-coupled receptor G2
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARSB arylsulfatase B
ASPN asporin
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BATF basic leucine zipper transcription factor, ATF-like
BCL2L2 BCL2-like 2
BTBD18 BTB (POZ) domain containing 18
BYSL bystin-like
C17ORF53 chromosome 17 open reading frame 53
C1RL complement component 1, r subcomponent-like
C4ORF29 chromosome 4 open reading frame 29
C5AR1 complement component 5a receptor 1
CCDC106 coiled-coil domain containing 106
CCDC9 coiled-coil domain containing 9
CEP170B centrosomal protein 170B
CEP97 centrosomal protein 97kDa
CES3 carboxylesterase 3
COL4A2 collagen, type IV, alpha 2
COQ6 coenzyme Q6 monooxygenase
CTNNBIP1 catenin, beta interacting protein 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DEAF1 DEAF1 transcription factor
DGAT1 diacylglycerol O-acyltransferase 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DOCK4 dedicator of cytokinesis 4
ELP6 elongator acetyltransferase complex subunit 6
EPHA4 EPH receptor A4
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV4 ets variant 4
EXOSC1 exosome component 1
FAM50B family with sequence similarity 50, member B
FANCF Fanconi anemia, complementation group F
FGL1 fibrinogen-like 1
FHOD1 formin homology 2 domain containing 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR27 G protein-coupled receptor 27
GUSBP3 glucuronidase, beta pseudogene 3
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H2BI histone cluster 1, H2bi
HYAL2 hyaluronoglucosaminidase 2
IFI6 interferon, alpha-inducible protein 6
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLHL28 kelch-like family member 28
LIMS2 LIM and senescent cell antigen-like domains 2
LOC100287590 uncharacterized LOC100287590
MECR mitochondrial trans-2-enoyl-CoA reductase
MICALL2 MICAL-like 2
MYBPH myosin binding protein H
NBEA neurobeachin
NDE1 nudE neurodevelopment protein 1
PARG poly (ADP-ribose) glycohydrolase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POM121 POM121 transmembrane nucleoporin
PORCN porcupine homolog (Drosophila)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTDSS2 phosphatidylserine synthase 2
PYHIN1 pyrin and HIN domain family, member 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL6 RAB, member RAS oncogene family-like 6
RAP1GAP2 RAP1 GTPase activating protein 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SALL2 spalt-like transcription factor 2
SCD5 stearoyl-CoA desaturase 5
SGPP1 sphingosine-1-phosphate phosphatase 1
SIRT6 sirtuin 6
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMYD5 SMYD family member 5
SPATA2L spermatogenesis associated 2-like
SPIDR scaffolding protein involved in DNA repair
SYCP2 synaptonemal complex protein 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAS2R10 taste receptor, type 2, member 10
TBXAS1 thromboxane A synthase 1 (platelet)
TMC7 transmembrane channel-like 7
TPM3 tropomyosin 3
TRIM25 tripartite motif containing 25
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC22D4 TSC22 domain family, member 4
TTLL1 tubulin tyrosine ligase-like family member 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
VNN1 vanin 1
WDR62 WD repeat domain 62
ZNF574 zinc finger protein 574
ZNF76 zinc finger protein 76