diphtheria Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys. (Experimental Factor Ontology, EFO_0005549)
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Genes

251 genes co-occuring with the disease diphtheria in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 3.24223
DPT dermatopontin 2.73926
HBEGF heparin-binding EGF-like growth factor 2.63977
TOX thymocyte selection-associated high mobility group box 2.00286
DPH5 diphthamide biosynthesis 5 1.91313
PARP1 poly (ADP-ribose) polymerase 1 1.80562
DPH1 diphthamide biosynthesis 1 1.71226
DPH2 DPH2 homolog (S. cerevisiae) 1.68453
IL2 interleukin 2 1.53172
DPH3 diphthamide biosynthesis 3 1.39477
CD79A CD79a molecule, immunoglobulin-associated alpha 1.32891
CD4 CD4 molecule 1.30183
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 1.22692
ART3 ADP-ribosyltransferase 3 1.21912
FURIN furin (paired basic amino acid cleaving enzyme) 1.18884
SRPR signal recognition particle receptor (docking protein) 1.17206
FOXP3 forkhead box P3 1.11099
IL2RA interleukin 2 receptor, alpha 1.11015
TF transferrin 1.07152
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 1.069
AGRP agouti related neuropeptide 1.03746
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.02945
IL3 interleukin 3 0.999924
CD9 CD9 molecule 0.996127
PARP10 poly (ADP-ribose) polymerase family, member 10 0.985585
ALB albumin 0.979268
URM1 ubiquitin related modifier 1 0.978426
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 0.956614
SERGEF secretion regulating guanine nucleotide exchange factor 0.876966
TMX3 thioredoxin-related transmembrane protein 3 0.852402
ART1 ADP-ribosyltransferase 1 0.841344
TFRC transferrin receptor 0.820026
PRPF18 pre-mRNA processing factor 18 0.816745
PARP15 poly (ADP-ribose) polymerase family, member 15 0.814693
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 0.813462
LGALS4 lectin, galactoside-binding, soluble, 4 0.808129
ADPRHL2 ADP-ribosylhydrolase like 2 0.781888
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 0.78066
ASCL3 achaete-scute family bHLH transcription factor 3 0.768393
IL13 interleukin 13 0.75412
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 0.750864
SLC35D3 solute carrier family 35, member D3 0.749644
OARD1 O-acyl-ADP-ribose deacylase 1 0.735433
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.722886
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.70233
HIST1H1T histone cluster 1, H1t 0.69751
ADPRH ADP-ribosylarginine hydrolase 0.691094
ZP4 zona pellucida glycoprotein 4 0.689092
KRT71 keratin 71, type II 0.682693
DTX3L deltex 3 like, E3 ubiquitin ligase 0.6791
ZBTB46 zinc finger and BTB domain containing 46 0.663181
PARP16 poly (ADP-ribose) polymerase family, member 16 0.662387
POMC proopiomelanocortin 0.645375
TES testin LIM domain protein 0.644981
P4HB prolyl 4-hydroxylase, beta polypeptide 0.642221
CD19 CD19 molecule 0.628065
PLAU plasminogen activator, urokinase 0.62728
HES5 hes family bHLH transcription factor 5 0.621792
EIF4H eukaryotic translation initiation factor 4H 0.614747
EGFR epidermal growth factor receptor 0.609276
TNF tumor necrosis factor 0.603811
FGF6 fibroblast growth factor 6 0.596402
GTPBP6 GTP binding protein 6 (putative) 0.596012
PARP14 poly (ADP-ribose) polymerase family, member 14 0.589779
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.588222
SIM1 single-minded family bHLH transcription factor 1 0.58433
OPN5 opsin 5 0.581996
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.574994
LYZ lysozyme 0.57305
NPY neuropeptide Y 0.568775
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.561392
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.552463
CSN1S1 casein alpha s1 0.550911
HEXB hexosaminidase B (beta polypeptide) 0.550911
NSUN5 NOP2/Sun domain family, member 5 0.550134
PRRC2A proline-rich coiled-coil 2A 0.540442
CRYAA crystallin, alpha A 0.529222
IGHV3-30 immunoglobulin heavy variable 3-30 0.528449
IGF2 insulin-like growth factor 2 0.524974
CCDC85B coiled-coil domain containing 85B 0.524202
RRM1 ribonucleotide reductase M1 0.51919
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.51842
IL4 interleukin 4 0.506123
CSRP1 cysteine and glycine-rich protein 1 0.498849
ZNF185 zinc finger protein 185 (LIM domain) 0.498849
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.493885
PMCH pro-melanin-concentrating hormone 0.493885
CD22 CD22 molecule 0.493122
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.491597
PITPNB phosphatidylinositol transfer protein, beta 0.490072
ANTXR1 anthrax toxin receptor 1 0.483604
MPI mannose phosphate isomerase 0.482084
MXD3 MAX dimerization protein 3 0.478289
SHB Src homology 2 domain containing adaptor protein B 0.476772
CD5 CD5 molecule 0.476014
TSPO translocator protein (18kDa) 0.475634
ARSB arylsulfatase B 0.474119
LPO lactoperoxidase 0.468819
GLB1 galactosidase, beta 1 0.460506
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.452585
M6PR mannose-6-phosphate receptor (cation dependent) 0.451831
FEV FEV (ETS oncogene family) 0.451454
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.450701
EPS15 epidermal growth factor receptor pathway substrate 15 0.449947
SUMF2 sulfatase modifying factor 2 0.43941
PEF1 penta-EF-hand domain containing 1 0.439034
DEFA4 defensin, alpha 4, corticostatin 0.434148
GPANK1 G patch domain and ankyrin repeats 1 0.431519
ACAT1 acetyl-CoA acetyltransferase 1 0.42139
BCL2L1 BCL2-like 1 0.419142
PVR poliovirus receptor 0.41727
DHFR dihydrofolate reductase 0.416896
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.41465
CD86 CD86 molecule 0.412779
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 0.411283
PCSK6 proprotein convertase subtilisin/kexin type 6 0.40904
NGF nerve growth factor (beta polypeptide) 0.408666
FOXD2 forkhead box D2 0.405305
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.403438
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.402692
IL6 interleukin 6 0.402318
PARP9 poly (ADP-ribose) polymerase family, member 9 0.401945
ISYNA1 inositol-3-phosphate synthase 1 0.399334
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.397098
INS insulin 0.396725
HCRT hypocretin (orexin) neuropeptide precursor 0.396353
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.395608
BTN2A1 butyrophilin, subfamily 2, member A1 0.390397
CALCOCO2 calcium binding and coiled-coil domain 2 0.389653
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.386308
IGHV3-9 immunoglobulin heavy variable 3-9 0.381852
BATF3 basic leucine zipper transcription factor, ATF-like 3 0.37555
RPS10 ribosomal protein S10 0.374068
HEXA hexosaminidase A (alpha polypeptide) 0.369628
FCGBP Fc fragment of IgG binding protein 0.367779
PRAMEF9 PRAME family member 9 0.364085
ELP2 elongator acetyltransferase complex subunit 2 0.355235
INA internexin neuronal intermediate filament protein, alpha 0.352291
FGF12 fibroblast growth factor 12 0.351923
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 0.348246
EEA1 early endosome antigen 1 0.345308
MACROD2 MACRO domain containing 2 0.341639
SETD7 SET domain containing (lysine methyltransferase) 7 0.340539
LEP leptin 0.333583
C6ORF25 chromosome 6 open reading frame 25 0.332121
CD40 CD40 molecule, TNF receptor superfamily member 5 0.33066
FCGRT Fc fragment of IgG, receptor, transporter, alpha 0.327375
SFTPC surfactant protein C 0.327375
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.32373
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.323002
PLAUR plasminogen activator, urokinase receptor 0.321545
CNR1 cannabinoid receptor 1 (brain) 0.320454
HDX highly divergent homeobox 0.318272
PAX7 paired box 7 0.314278
ADGRE1 adhesion G protein-coupled receptor E1 0.313915
CLEC4C C-type lectin domain family 4, member C 0.313915
MACROD1 MACRO domain containing 1 0.313915
SETDB1 SET domain, bifurcated 1 0.312102
ELF4 E74-like factor 4 (ets domain transcription factor) 0.308118
RNASET2 ribonuclease T2 0.307757
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.307757
DEFA3 defensin, alpha 3, neutrophil-specific 0.307395
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 0.30342
SLC7A4 solute carrier family 7, member 4 0.298731
TAT tyrosine aminotransferase 0.297291
DEGS1 delta(4)-desaturase, sphingolipid 1 0.295851
METAP1 methionyl aminopeptidase 1 0.287593
IL7 interleukin 7 0.282582
ERBB4 erb-b2 receptor tyrosine kinase 4 0.278297
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.275801
DTX1 deltex 1, E3 ubiquitin ligase 0.275445
ADCY2 adenylate cyclase 2 (brain) 0.274021
DNAH8 dynein, axonemal, heavy chain 8 0.27153
ALLC allantoicase 0.270819
PRAMEF12 PRAME family member 12 0.270108
CD80 CD80 molecule 0.266913
TSKU tsukushi, small leucine rich proteoglycan 0.264431
CNTF ciliary neurotrophic factor 0.263722
KLB klotho beta 0.260891
BBS9 Bardet-Biedl syndrome 9 0.25877
CSNK2B casein kinase 2, beta polypeptide 0.257711
IL10 interleukin 10 0.255594
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.253831
IL1B interleukin 1, beta 0.250663
HADH hydroxyacyl-CoA dehydrogenase 0.250311
ARSI arylsulfatase family, member I 0.248554
BORA bora, aurora kinase A activator 0.247501
POU4F3 POU class 4 homeobox 3 0.246799
PDYN prodynorphin 0.243995
ACTB actin, beta 0.243295
HLA-B major histocompatibility complex, class I, B 0.241895
LDLR low density lipoprotein receptor 0.241546
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.238752
CEP104 centrosomal protein 104kDa 0.235268
LMX1B LIM homeobox transcription factor 1, beta 0.234225
AK2 adenylate kinase 2 0.231795
ENSA endosulfine alpha 0.230409
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.229716
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.229024
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.228679
XCR1 chemokine (C motif) receptor 1 0.227988
IL2RG interleukin 2 receptor, gamma 0.226262
ALAD aminolevulinate dehydratase 0.223509
GCG glucagon 0.223165
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.222822
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.218034
CNTN4 contactin 4 0.218034
ACTG1 actin gamma 1 0.215653
THY1 Thy-1 cell surface antigen 0.214297
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.214297
PNP purine nucleoside phosphorylase 0.213283
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.208914
CSK c-src tyrosine kinase 0.207912
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.206913
PEX6 peroxisomal biogenesis factor 6 0.206913
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.20229
ADCY4 adenylate cyclase 4 0.198709
PNN pinin, desmosome associated protein 0.19742
PPY pancreatic polypeptide 0.196459
ATF5 activating transcription factor 5 0.194232
BBS10 Bardet-Biedl syndrome 10 0.191097
PAM peptidylglycine alpha-amidating monooxygenase 0.190168
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.188326
ASCL2 achaete-scute family bHLH transcription factor 2 0.187719
POU4F2 POU class 4 homeobox 2 0.18591
HAMP hepcidin antimicrobial peptide 0.183248
ADCY7 adenylate cyclase 7 0.181798
BAG6 BCL2-associated athanogene 6 0.178682
PAX3 paired box 3 0.178403
CD53 CD53 molecule 0.175947
CAV1 caveolin 1, caveolae protein, 22kDa 0.173832
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.173571
FBXO42 F-box protein 42 0.171286
ERBB2 erb-b2 receptor tyrosine kinase 2 0.171036
TAC1 tachykinin, precursor 1 0.170789
GUSB glucuronidase, beta 0.170299
ALPP alkaline phosphatase, placental 0.167452
MRC1 mannose receptor, C type 1 0.166544
RAD51 RAD51 recombinase 0.165874
ALPPL2 alkaline phosphatase, placental-like 2 0.165655
ALPL alkaline phosphatase, liver/bone/kidney 0.165217
ACP2 acid phosphatase 2, lysosomal 0.164149
UTS2 urotensin 2 0.164149
FGFR4 fibroblast growth factor receptor 4 0.162306
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.162109
CCKBR cholecystokinin B receptor 0.161523
CCDC27 coiled-coil domain containing 27 0.161523
IL13RA2 interleukin 13 receptor, alpha 2 0.160761
MB myoglobin 0.160574
GAST gastrin 0.160387
UCN3 urocortin 3 0.15948