dipivefrine-1752 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the dipivefrine-1752 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AKAP13 A kinase (PRKA) anchor protein 13
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARL4C ADP-ribosylation factor-like 4C
ARMC7 armadillo repeat containing 7
ARRB2 arrestin, beta 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BEX1 brain expressed, X-linked 1
BIN1 bridging integrator 1
CD86 CD86 molecule
CDK12 cyclin-dependent kinase 12
CHN2 chimerin 2
CLCN7 chloride channel, voltage-sensitive 7
CLPTM1 cleft lip and palate associated transmembrane protein 1
CREB3 cAMP responsive element binding protein 3
CREM cAMP responsive element modulator
CSNK1D casein kinase 1, delta
CYTH1 cytohesin 1
DNAH17 dynein, axonemal, heavy chain 17
DNM2 dynamin 2
DOCK4 dedicator of cytokinesis 4
DUSP4 dual specificity phosphatase 4
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELMO2 engulfment and cell motility 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GMIP GEM interacting protein
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTSE1 G-2 and S-phase expressed 1
HDLBP high density lipoprotein binding protein
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
IL10RA interleukin 10 receptor, alpha
IL1R1 interleukin 1 receptor, type I
IL4R interleukin 4 receptor
INPPL1 inositol polyphosphate phosphatase-like 1
ISG20 interferon stimulated exonuclease gene 20kDa
KDM4B lysine (K)-specific demethylase 4B
KIAA0226 KIAA0226
KYNU kynureninase
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPPR2 lipid phosphate phosphatase-related protein type 2
MAN1B1 mannosidase, alpha, class 1B, member 1
MAP2K5 mitogen-activated protein kinase kinase 5
MCAM melanoma cell adhesion molecule
MED15 mediator complex subunit 15
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOB3B MOB kinase activator 3B
MTMR3 myotubularin related protein 3
NDRG2 NDRG family member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUCB1 nucleobindin 1
NUP62 nucleoporin 62kDa
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM7 PDZ and LIM domain 7 (enigma)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PILRB paired immunoglobin-like type 2 receptor beta
PISD phosphatidylserine decarboxylase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLSCR1 phospholipid scramblase 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R16B protein phosphatase 1, regulatory subunit 16B
RAB31 RAB31, member RAS oncogene family
RHOT2 ras homolog family member T2
RUNX3 runt-related transcription factor 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SDC2 syndecan 2
SGK1 serum/glucocorticoid regulated kinase 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIK2 salt-inducible kinase 2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SMOX spermine oxidase
SPTAN1 spectrin, alpha, non-erythrocytic 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
THBS1 thrombospondin 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM74B transmembrane protein 74B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRMT61A tRNA methyltransferase 61A
USB1 U6 snRNA biogenesis 1
ZNF710 zinc finger protein 710
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABT1 activator of basal transcription 1
ALG3 ALG3, alpha-1,3- mannosyltransferase
ANKRD36 ankyrin repeat domain 36
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL10 B-cell CLL/lymphoma 10
C12ORF29 chromosome 12 open reading frame 29
C14ORF159 chromosome 14 open reading frame 159
C19ORF24 chromosome 19 open reading frame 24
C5ORF30 chromosome 5 open reading frame 30
CA2 carbonic anhydrase II
CCDC6 coiled-coil domain containing 6
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCNT1 cyclin T1
CD302 CD302 molecule
CD9 CD9 molecule
CDC73 cell division cycle 73
CRIP1 cysteine-rich protein 1 (intestinal)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCTPP1 dCTP pyrophosphatase 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DENND4A DENN/MADD domain containing 4A
DNAAF2 dynein, axonemal, assembly factor 2
EBNA1BP2 EBNA1 binding protein 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ETV6 ets variant 6
EXOC5 exocyst complex component 5
FAM188A family with sequence similarity 188, member A
FAR2 fatty acyl CoA reductase 2
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FLT3 fms-related tyrosine kinase 3
FUBP3 far upstream element (FUSE) binding protein 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTF2I general transcription factor IIi
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HOOK2 hook microtubule-tethering protein 2
HRSP12 heat-responsive protein 12
HSPE1 heat shock 10kDa protein 1
IFITM2 interferon induced transmembrane protein 2
KIAA0020 KIAA0020
KIFC1 kinesin family member C1
L2HGDH L-2-hydroxyglutarate dehydrogenase
LMAN1 lectin, mannose-binding, 1
LY75 lymphocyte antigen 75
MAGOHB mago-nashi homolog B (Drosophila)
MIS18BP1 MIS18 binding protein 1
MOCOS molybdenum cofactor sulfurase
MRPL4 mitochondrial ribosomal protein L4
MRPL40 mitochondrial ribosomal protein L40
MRPS28 mitochondrial ribosomal protein S28
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
NCF1C neutrophil cytosolic factor 1C pseudogene
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NT5C 5', 3'-nucleotidase, cytosolic
NUP93 nucleoporin 93kDa
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PLCD1 phospholipase C, delta 1
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
PRDM13 PR domain containing 13
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PSENEN presenilin enhancer gamma secretase subunit
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB4B RAB4B, member RAS oncogene family
RNF167 ring finger protein 167
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPE ribulose-5-phosphate-3-epimerase
RPP40 ribonuclease P/MRP 40kDa subunit
RUVBL1 RuvB-like AAA ATPase 1
SEC61B Sec61 beta subunit
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SLC25A40 solute carrier family 25, member 40
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPP1 secreted phosphoprotein 1
STAU2 staufen double-stranded RNA binding protein 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TCTN2 tectonic family member 2
TM7SF2 transmembrane 7 superfamily member 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM230 transmembrane protein 230
TMEM45A transmembrane protein 45A
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TOE1 target of EGR1, member 1 (nuclear)
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIM25 tripartite motif containing 25
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
WDR12 WD repeat domain 12
XAF1 XIAP associated factor 1