diprophylline-1853 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the diprophylline-1853 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABR active BCR-related
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
ALS2CL ALS2 C-terminal like
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARNT aryl hydrocarbon receptor nuclear translocator
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDC14A cell division cycle 14A
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CTC1 CTS telomere maintenance complex component 1
CYB561 cytochrome b561
DAPK3 death-associated protein kinase 3
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNASE2 deoxyribonuclease II, lysosomal
DSTYK dual serine/threonine and tyrosine protein kinase
E2F4 E2F transcription factor 4, p107/p130-binding
EFNA3 ephrin-A3
EPHB2 EPH receptor B2
ERN2 endoplasmic reticulum to nucleus signaling 2
ERP44 endoplasmic reticulum protein 44
FAS Fas cell surface death receptor
FCF1 FCF1 rRNA-processing protein
FKBP5 FK506 binding protein 5
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GK3P glycerol kinase 3 pseudogene
HIPK2 homeodomain interacting protein kinase 2
HK2 hexokinase 2
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA4 heat shock 70kDa protein 4
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
ITGB1BP1 integrin beta 1 binding protein 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KIAA0355 KIAA0355
KPNB1 karyopherin (importin) beta 1
KRIT1 KRIT1, ankyrin repeat containing
LIG4 ligase IV, DNA, ATP-dependent
LPAR1 lysophosphatidic acid receptor 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAPK3 mitogen-activated protein kinase 3
MAST2 microtubule associated serine/threonine kinase 2
MCOLN1 mucolipin 1
MED28 mediator complex subunit 28
MED6 mediator complex subunit 6
MIS18BP1 MIS18 binding protein 1
MMP19 matrix metallopeptidase 19
MST1 macrophage stimulating 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MZT2B mitotic spindle organizing protein 2B
NCDN neurochondrin
NDE1 nudE neurodevelopment protein 1
NEFH neurofilament, heavy polypeptide
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDLIM7 PDZ and LIM domain 7 (enigma)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PICALM phosphatidylinositol binding clathrin assembly protein
POFUT1 protein O-fucosyltransferase 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RHOBTB2 Rho-related BTB domain containing 2
RPL35A ribosomal protein L35a
RPP25 ribonuclease P/MRP 25kDa subunit
RPS2 ribosomal protein S2
RYK receptor-like tyrosine kinase
SCN10A sodium channel, voltage gated, type X alpha subunit
SERBP1 SERPINE1 mRNA binding protein 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SHARPIN SHANK-associated RH domain interactor
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC25A44 solute carrier family 25, member 44
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SOX4 SRY (sex determining region Y)-box 4
SUGP1 SURP and G patch domain containing 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPD52 tumor protein D52
TPI1 triosephosphate isomerase 1
TPP1 tripeptidyl peptidase I
TRIM36 tripartite motif containing 36
TSPAN4 tetraspanin 4
USP46 ubiquitin specific peptidase 46
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB40 zinc finger and BTB domain containing 40
ZC3H3 zinc finger CCCH-type containing 3
ZNF668 zinc finger protein 668
ZNF783 zinc finger family member 783
ZNF816 zinc finger protein 816

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AEN apoptosis enhancing nuclease
ARHGAP12 Rho GTPase activating protein 12
ASTE1 asteroid homolog 1 (Drosophila)
BAMBI BMP and activin membrane-bound inhibitor
C7ORF43 chromosome 7 open reading frame 43
CCDC9 coiled-coil domain containing 9
CENPT centromere protein T
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN15 claudin 15
CORO7 coronin 7
DENND1C DENN/MADD domain containing 1C
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNASE1L1 deoxyribonuclease I-like 1
DOLK dolichol kinase
DTX4 deltex 4, E3 ubiquitin ligase
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC8 excision repair cross-complementation group 8
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNS galactosamine (N-acetyl)-6-sulfatase
GIPC1 GIPC PDZ domain containing family, member 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR27 G protein-coupled receptor 27
HIST1H2BC histone cluster 1, H2bc
HIST1H2BI histone cluster 1, H2bi
HIST1H2BJ histone cluster 1, H2bj
HIST1H3H histone cluster 1, H3h
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
LINC00597 long intergenic non-protein coding RNA 597
LOC157562 uncharacterized LOC157562
LY6E lymphocyte antigen 6 complex, locus E
MANSC1 MANSC domain containing 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAST3 microtubule associated serine/threonine kinase 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MDM4 MDM4, p53 regulator
MED9 mediator complex subunit 9
METTL1 methyltransferase like 1
MOB3B MOB kinase activator 3B
MOCS3 molybdenum cofactor synthesis 3
MRPL44 mitochondrial ribosomal protein L44
NARFL nuclear prelamin A recognition factor-like
NINJ2 ninjurin 2
NKRF NFKB repressing factor
NPM3 nucleophosmin/nucleoplasmin 3
NT5C 5', 3'-nucleotidase, cytosolic
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PADI2 peptidyl arginine deiminase, type II
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
POLH polymerase (DNA directed), eta
PRAF2 PRA1 domain family, member 2
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRR7 proline rich 7 (synaptic)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTH2R parathyroid hormone 2 receptor
PYCR1 pyrroline-5-carboxylate reductase 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RPAP1 RNA polymerase II associated protein 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCAMP3 secretory carrier membrane protein 3
SECISBP2 SECIS binding protein 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SNHG20 small nucleolar RNA host gene 20
SRD5A3 steroid 5 alpha-reductase 3
STX5 syntaxin 5
SURF2 surfeit 2
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TESK1 testis-specific kinase 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIMP2 TIMP metallopeptidase inhibitor 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM134 transmembrane protein 134
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOLLIP toll interacting protein
TPRA1 transmembrane protein, adipocyte asscociated 1
TRIM25 tripartite motif containing 25
TUFT1 tuftelin 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UNC119 unc-119 homolog (C. elegans)
UPK3A uroplakin 3A
USB1 U6 snRNA biogenesis 1
WDR33 WD repeat domain 33
XYLT2 xylosyltransferase II
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF215 zinc finger protein 215
ZNF32 zinc finger protein 32
ZNF506 zinc finger protein 506
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862
ZNHIT2 zinc finger, HIT-type containing 2
ZNRD1-AS1 ZNRD1 antisense RNA 1