dirithromycin-1712 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the dirithromycin-1712 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADAM12 ADAM metallopeptidase domain 12
ADRA2B adrenoceptor alpha 2B
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALOXE3 arachidonate lipoxygenase 3
ATF6B activating transcription factor 6 beta
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BIRC7 baculoviral IAP repeat containing 7
BMP2K BMP2 inducible kinase
C7ORF43 chromosome 7 open reading frame 43
CA12 carbonic anhydrase XII
CACFD1 calcium channel flower domain containing 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALB2 calbindin 2
CEND1 cell cycle exit and neuronal differentiation 1
CHN2 chimerin 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CLTA clathrin, light chain A
CNTFR ciliary neurotrophic factor receptor
CNTNAP1 contactin associated protein 1
COL18A1 collagen, type XVIII, alpha 1
COMT catechol-O-methyltransferase
CORT cortistatin
CPM carboxypeptidase M
CPNE7 copine VII
CXCL12 chemokine (C-X-C motif) ligand 12
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAH7 dynein, axonemal, heavy chain 7
DSPP dentin sialophosphoprotein
DUSP26 dual specificity phosphatase 26 (putative)
EFR3B EFR3 homolog B (S. cerevisiae)
FBRS fibrosin
FOXC1 forkhead box C1
FSCN1 fascin actin-bundling protein 1
GIPC1 GIPC PDZ domain containing family, member 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
HAB1 B1 for mucin
HAMP hepcidin antimicrobial peptide
HAND1 heart and neural crest derivatives expressed 1
IGHA1 immunoglobulin heavy constant alpha 1
IHH indian hedgehog
IL2RB interleukin 2 receptor, beta
IQCC IQ motif containing C
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
L1TD1 LINE-1 type transposase domain containing 1
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LIMS2 LIM and senescent cell antigen-like domains 2
LINC00312 long intergenic non-protein coding RNA 312
MIIP migration and invasion inhibitory protein
MMP25 matrix metallopeptidase 25
MOSPD3 motile sperm domain containing 3
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXRA8 matrix-remodelling associated 8
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NCR2 natural cytotoxicity triggering receptor 2
NIPAL2 NIPA-like domain containing 2
NPEPL1 aminopeptidase-like 1
PADI1 peptidyl arginine deiminase, type I
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PKP3 plakophilin 3
PLCG1 phospholipase C, gamma 1
PLK3 polo-like kinase 3
PPP5C protein phosphatase 5, catalytic subunit
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PRODH2 proline dehydrogenase (oxidase) 2
PTGES prostaglandin E synthase
PTN pleiotrophin
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB2A RAB2A, member RAS oncogene family
RPL7 ribosomal protein L7
RXRA retinoid X receptor, alpha
SALL2 spalt-like transcription factor 2
SCN5A sodium channel, voltage gated, type V alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPDEF SAM pointed domain containing ETS transcription factor
TLE4 transducin-like enhancer of split 4
TMCC2 transmembrane and coiled-coil domain family 2
TMEM212 transmembrane protein 212
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRAPPC9 trafficking protein particle complex 9
TSPAN9 tetraspanin 9
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TYR tyrosinase
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VGF VGF nerve growth factor inducible
WFDC8 WAP four-disulfide core domain 8
ZFHX2 zinc finger homeobox 2
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABT1 activator of basal transcription 1
AES amino-terminal enhancer of split
ANAPC15 anaphase promoting complex subunit 15
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARL4A ADP-ribosylation factor-like 4A
ARRB2 arrestin, beta 2
ASTE1 asteroid homolog 1 (Drosophila)
AVEN apoptosis, caspase activation inhibitor
BARD1 BRCA1 associated RING domain 1
BCL7C B-cell CLL/lymphoma 7C
BLVRB biliverdin reductase B
BYSL bystin-like
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CAPN15 calpain 15
CCL20 chemokine (C-C motif) ligand 20
CCNL2 cyclin L2
CDCA8 cell division cycle associated 8
CFL1 cofilin 1 (non-muscle)
CLCN6 chloride channel, voltage-sensitive 6
CLDN15 claudin 15
COMMD9 COMM domain containing 9
CORO7 coronin 7
CRIP1 cysteine-rich protein 1 (intestinal)
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
DBF4B DBF4 zinc finger B
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
EMC9 ER membrane protein complex subunit 9
ENDOG endonuclease G
ENO2 enolase 2 (gamma, neuronal)
FZD2 frizzled class receptor 2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GOLPH3L golgi phosphoprotein 3-like
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HMGB3P1 high mobility group box 3 pseudogene 1
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KEAP1 kelch-like ECH-associated protein 1
KLF13 Kruppel-like factor 13
KRBOX4 KRAB box domain containing 4
LIG1 ligase I, DNA, ATP-dependent
MAN2B1 mannosidase, alpha, class 2B, member 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPV17 MpV17 mitochondrial inner membrane protein
MRPL4 mitochondrial ribosomal protein L4
MSRB1 methionine sulfoxide reductase B1
MT1HL1 metallothionein 1H-like 1
MTG1 mitochondrial ribosome-associated GTPase 1
MYLIP myosin regulatory light chain interacting protein
NADSYN1 NAD synthetase 1
NFE2 nuclear factor, erythroid 2
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NUP93 nucleoporin 93kDa
NVL nuclear VCP-like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
ORC1 origin recognition complex, subunit 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAK1IP1 PAK1 interacting protein 1
PAQR4 progestin and adipoQ receptor family member IV
PCTP phosphatidylcholine transfer protein
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PSKH1 protein serine kinase H1
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB4B RAB4B, member RAS oncogene family
RABEPK Rab9 effector protein with kelch motifs
RBM10 RNA binding motif protein 10
RBM14 RNA binding motif protein 14
RHOH ras homolog family member H
RNF144A ring finger protein 144A
RNF167 ring finger protein 167
RWDD2B RWD domain containing 2B
SAC3D1 SAC3 domain containing 1
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMG9 SMG9 nonsense mediated mRNA decay factor
SNX6 sorting nexin 6
STRA13 stimulated by retinoic acid 13
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TEX264 testis expressed 264
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TRIM28 tripartite motif containing 28
TST thiosulfate sulfurtransferase (rhodanese)
TTPAL tocopherol (alpha) transfer protein-like
UBE2M ubiquitin-conjugating enzyme E2M
VKORC1 vitamin K epoxide reductase complex, subunit 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
WDR6 WD repeat domain 6
ZBTB48 zinc finger and BTB domain containing 48