disc Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. (Gene Ontology, GO_0031264)
Similar Terms
Downloads & Tools

Genes

153 genes co-occuring with the biological term disc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAN aggrecan
ADAM17 ADAM metallopeptidase domain 17
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANKH ANKH inorganic pyrophosphate transport regulator
APOA2 apolipoprotein A-II
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
AQP2 aquaporin 2 (collecting duct)
AQP3 aquaporin 3 (Gill blood group)
ASPN asporin
ATOH7 atonal homolog 7 (Drosophila)
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BID BH3 interacting domain death agonist
BMP10 bone morphogenetic protein 10
BMP7 bone morphogenetic protein 7
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CARD10 caspase recruitment domain family, member 10
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL11A1 collagen, type XI, alpha 1
COL2A1 collagen, type II, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
COMT catechol-O-methyltransferase
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
DCT dopachrome tautomerase
DISC1 disrupted in schizophrenia 1
EGFR epidermal growth factor receptor
ELN elastin
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FN1 fibronectin 1
GCH1 GTP cyclohydrolase 1
GCOM1 GRINL1A complex locus 1
GDF5 growth differentiation factor 5
GMDS GDP-mannose 4,6-dehydratase
HAPLN1 hyaluronan and proteoglycan link protein 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HOXD10 homeobox D10
HSF1 heat shock transcription factor 1
HSPG2 heparan sulfate proteoglycan 2
HTRA1 HtrA serine peptidase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL20 interleukin 20
IL37 interleukin 37
IL6 interleukin 6
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNK2 potassium channel, two pore domain subfamily K, member 2
KIAA1217 KIAA1217
KIF20A kinesin family member 20A
LCK LCK proto-oncogene, Src family tyrosine kinase
LECT1 leukocyte cell derived chemotaxin 1
LEP leptin
LEPR leptin receptor
LTBP2 latent transforming growth factor beta binding protein 2
MAPK14 mitogen-activated protein kinase 14
MET MET proto-oncogene, receptor tyrosine kinase
MFAP2 microfibrillar-associated protein 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR10B microRNA 10b
MIR155 microRNA 155
MIR21 microRNA 21
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP28 matrix metallopeptidase 28
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MYH10 myosin, heavy chain 10, non-muscle
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPRM1 opioid receptor, mu 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PECAM1 platelet/endothelial cell adhesion molecule 1
POSTN periostin, osteoblast specific factor
PRG4 proteoglycan 4
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RANBP2 RAN binding protein 2
RHO rhodopsin
RHOC ras homolog family member C
RPS3 ribosomal protein S3
SDC4 syndecan 4
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SIRT1 sirtuin 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCAP titin-cap
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
THSD1 thrombospondin, type I, domain containing 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WDR81 WD repeat domain 81