disopyramide-2408 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the disopyramide-2408 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
AFF3 AF4/FMR2 family, member 3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMACR alpha-methylacyl-CoA racemase
ANXA2P3 annexin A2 pseudogene 3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARL4C ADP-ribosylation factor-like 4C
ATG10 autophagy related 10
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCL23 chemokine (C-C motif) ligand 23
CD300C CD300c molecule
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CD79B CD79b molecule, immunoglobulin-associated beta
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEP250 centrosomal protein 250kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLSTN2 calsyntenin 2
CTTN cortactin
CYHR1 cysteine/histidine-rich 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DGCR8 DGCR8 microprocessor complex subunit
DPY19L1 dpy-19-like 1 (C. elegans)
DTNA dystrobrevin, alpha
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM127B family with sequence similarity 127, member B
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GID4 GID complex subunit 4
GPR107 G protein-coupled receptor 107
HDAC7 histone deacetylase 7
HHLA3 HERV-H LTR-associating 3
HIST1H2AM histone cluster 1, H2am
HIST1H2BC histone cluster 1, H2bc
HOMER3 homer scaffolding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
ING2 inhibitor of growth family, member 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIF13B kinesin family member 13B
KIF1A kinesin family member 1A
KIF1C kinesin family member 1C
LEF1 lymphoid enhancer-binding factor 1
LOXL3 lysyl oxidase-like 3
LPAR2 lysophosphatidic acid receptor 2
LPP LIM domain containing preferred translocation partner in lipoma
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRC75B leucine rich repeat containing 75B
MACF1 microtubule-actin crosslinking factor 1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MVK mevalonate kinase
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYL10 myosin, light chain 10, regulatory
NEK1 NIMA-related kinase 1
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP3 NLR family, pyrin domain containing 3
NOP16 NOP16 nucleolar protein
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PDE4A phosphodiesterase 4A, cAMP-specific
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM5 PDZ and LIM domain 5
PHC1 polyhomeotic homolog 1 (Drosophila)
PINK1 PTEN induced putative kinase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCH1 phospholipase C, eta 1
POU6F2 POU class 6 homeobox 2
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAB40A RAB40A, member RAS oncogene family
RGS12 regulator of G-protein signaling 12
RGS3 regulator of G-protein signaling 3
RIF1 replication timing regulatory factor 1
RYR1 ryanodine receptor 1 (skeletal)
SELPLG selectin P ligand
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SLC25A44 solute carrier family 25, member 44
SMYD2 SET and MYND domain containing 2
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOS2 son of sevenless homolog 2 (Drosophila)
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
TCF3 transcription factor 3
TFEB transcription factor EB
TGM2 transglutaminase 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNK2 tyrosine kinase, non-receptor, 2
UBXN1 UBX domain protein 1
UROD uroporphyrinogen decarboxylase
WHSC1 Wolf-Hirschhorn syndrome candidate 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALS2CL ALS2 C-terminal like
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ART1 ADP-ribosyltransferase 1
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
BAK1 BCL2-antagonist/killer 1
BAMBI BMP and activin membrane-bound inhibitor
BBC3 BCL2 binding component 3
BCORL1 BCL6 corepressor-like 1
BSPRY B-box and SPRY domain containing
C1ORF105 chromosome 1 open reading frame 105
C1ORF56 chromosome 1 open reading frame 56
C1ORF95 chromosome 1 open reading frame 95
C5ORF28 chromosome 5 open reading frame 28
C9ORF9 chromosome 9 open reading frame 9
CASZ1 castor zinc finger 1
CCDC71 coiled-coil domain containing 71
CD34 CD34 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CECR1 cat eye syndrome chromosome region, candidate 1
CNPY4 canopy FGF signaling regulator 4
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CXORF56 chromosome X open reading frame 56
DDN dendrin
DHRS3 dehydrogenase/reductase (SDR family) member 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYSF dysferlin
ECI2 enoyl-CoA delta isomerase 2
ERCC4 excision repair cross-complementation group 4
ETV4 ets variant 4
F3 coagulation factor III (thromboplastin, tissue factor)
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FGGY FGGY carbohydrate kinase domain containing
FOS FBJ murine osteosarcoma viral oncogene homolog
GRAMD1B GRAM domain containing 1B
GRIP2 glutamate receptor interacting protein 2
GTF2IRD1 GTF2I repeat domain containing 1
HOPX HOP homeobox
HYAL2 hyaluronoglucosaminidase 2
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFT81 intraflagellar transport 81
INO80D INO80 complex subunit D
ITGB7 integrin, beta 7
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIAA0753 KIAA0753
KIAA1024 KIAA1024
KLF1 Kruppel-like factor 1 (erythroid)
LAX1 lymphocyte transmembrane adaptor 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MBIP MAP3K12 binding inhibitory protein 1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MILR1 mast cell immunoglobulin-like receptor 1
MLPH melanophilin
MRPL46 mitochondrial ribosomal protein L46
MTG1 mitochondrial ribosome-associated GTPase 1
NKX3-2 NK3 homeobox 2
NXF2 nuclear RNA export factor 2
PIAS3 protein inhibitor of activated STAT, 3
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POM121 POM121 transmembrane nucleoporin
POR P450 (cytochrome) oxidoreductase
PQLC2 PQ loop repeat containing 2
PRKG2 protein kinase, cGMP-dependent, type II
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PYCRL pyrroline-5-carboxylate reductase-like
RAB3A RAB3A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASE3 ribonuclease, RNase A family, 3
RNF121 ring finger protein 121
RPAP1 RNA polymerase II associated protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SCML1 sex comb on midleg-like 1 (Drosophila)
SETD8 SET domain containing (lysine methyltransferase) 8
SPATA2L spermatogenesis associated 2-like
SSTR5 somatostatin receptor 5
STXBP5L syntaxin binding protein 5-like
TBC1D2 TBC1 domain family, member 2
TBXAS1 thromboxane A synthase 1 (platelet)
TCTN2 tectonic family member 2
TGM5 transglutaminase 5
TM7SF2 transmembrane 7 superfamily member 2
TMEM156 transmembrane protein 156
TMEM187 transmembrane protein 187
TMEM242 transmembrane protein 242
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UCN urocortin
UNC119 unc-119 homolog (C. elegans)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR91 WD repeat domain 91
WFDC2 WAP four-disulfide core domain 2
ZNF232 zinc finger protein 232
ZNF254 zinc finger protein 254
ZNF276 zinc finger protein 276
ZNF493 zinc finger protein 493