disrupted Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

282 genes co-occuring with the biological term disrupted in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
AFF1 AF4/FMR2 family, member 1
AHR aryl hydrocarbon receptor
AKAP9 A kinase (PRKA) anchor protein 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALK anaplastic lymphoma receptor tyrosine kinase
AMBRA1 autophagy/beclin-1 regulator 1
ANGPT2 angiopoietin 2
ANK1 ankyrin 1, erythrocytic
AP1S3 adaptor-related protein complex 1, sigma 3 subunit
APAF1 apoptotic peptidase activating factor 1
APOA1 apolipoprotein A-I
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
AR androgen receptor
ARID1A AT rich interactive domain 1A (SWI-like)
ASCL1 achaete-scute family bHLH transcription factor 1
ASXL1 additional sex combs like transcriptional regulator 1
ATOH1 atonal homolog 1 (Drosophila)
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATR ATR serine/threonine kinase
BARD1 BRCA1 associated RING domain 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BDNF brain-derived neurotrophic factor
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C10ORF2 chromosome 10 open reading frame 2
C12ORF42 chromosome 12 open reading frame 42
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAND1 cullin-associated and neddylation-dissociated 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL4 chemokine (C-C motif) ligand 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD40LG CD40 ligand
CD81 CD81 molecule
CDC20 cell division cycle 20
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP152 centrosomal protein 152kDa
CFL2 cofilin 2 (muscle)
CHEK1 checkpoint kinase 1
CLN3 ceroid-lipofuscinosis, neuronal 3
CNR1 cannabinoid receptor 1 (brain)
CNTNAP2 contactin associated protein-like 2
COPA coatomer protein complex, subunit alpha
CREB3L2 cAMP responsive element binding protein 3-like 2
CSPG4 chondroitin sulfate proteoglycan 4
CTCF CCCTC-binding factor (zinc finger protein)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCR4 chemokine (C-X-C motif) receptor 4
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DBN1 drebrin 1
DCTN1 dynactin 1
DES desmin
DICER1 dicer 1, ribonuclease type III
DISC1 disrupted in schizophrenia 1
DKC1 dyskeratosis congenita 1, dyskerin
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
DROSHA drosha, ribonuclease type III
DYNLT1 dynein, light chain, Tctex-type 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELMO1 engulfment and cell motility 1
EP300 E1A binding protein p300
EPHA3 EPH receptor A3
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
F2RL3 coagulation factor II (thrombin) receptor-like 3
FANCC Fanconi anemia, complementation group C
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FBXO32 F-box protein 32
FBXW4 F-box and WD repeat domain containing 4
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHIT fragile histidine triad
FIGLA folliculogenesis specific basic helix-loop-helix
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FOXP2 forkhead box P2
FRG1B FSHD region gene 1 family, member B
FURIN furin (paired basic amino acid cleaving enzyme)
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GFM1 G elongation factor, mitochondrial 1
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GJB2 gap junction protein, beta 2, 26kDa
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GRM3 glutamate receptor, metabotropic 3
GSK3B glycogen synthase kinase 3 beta
HAMP hepcidin antimicrobial peptide
HBB hemoglobin, beta
HDAC6 histone deacetylase 6
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-A major histocompatibility complex, class I, A
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTT huntingtin
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL6 interleukin 6
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
INHA inhibin, alpha
IP6K1 inositol hexakisphosphate kinase 1
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KAT8 K(lysine) acetyltransferase 8
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2
KIAA2022 KIAA2022
KLF11 Kruppel-like factor 11
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT10 keratin 10, type I
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LRRK2 leucine-rich repeat kinase 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MECP2 methyl CpG binding protein 2
MEF2C myocyte enhancer factor 2C
MESDC2 mesoderm development candidate 2
MET MET proto-oncogene, receptor tyrosine kinase
MLH1 mutL homolog 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP9 matrix metallopeptidase 9
MSTN myostatin
MTM1 myotubularin 1
NBAS neuroblastoma amplified sequence
NBEA neurobeachin
NCF1C neutrophil cytosolic factor 1C pseudogene
NCF2 neutrophil cytosolic factor 2
NCR1 natural cytotoxicity triggering receptor 1
NCR2 natural cytotoxicity triggering receptor 2
NCSTN nicastrin
NDE1 nudE neurodevelopment protein 1
NDEL1 nudE neurodevelopment protein 1-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLGN4X neuroligin 4, X-linked
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRXN1 neurexin 1
NTNG1 netrin G1
ORAI1 ORAI calcium release-activated calcium modulator 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PAH phenylalanine hydroxylase
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PAX5 paired box 5
PDGFB platelet-derived growth factor beta polypeptide
PER1 period circadian clock 1
PEX13 peroxisomal biogenesis factor 13
PFDN2 prefoldin subunit 2
PFDN5 prefoldin subunit 5
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLAUR plasminogen activator, urokinase receptor
PLK4 polo-like kinase 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2F3 POU class 2 homeobox 3
PPARG peroxisome proliferator-activated receptor gamma
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRDM1 PR domain containing 1, with ZNF domain
PRKCE protein kinase C, epsilon
PRL prolactin
PRSS1 protease, serine, 1 (trypsin 1)
PTEN phosphatase and tensin homolog
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRD protein tyrosine phosphatase, receptor type, D
PTTG1 pituitary tumor-transforming 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAN RAN, member RAS oncogene family
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RDX radixin
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RET ret proto-oncogene
RHOA ras homolog family member A
RHOB ras homolog family member B
RIOK2 RIO kinase 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPL11 ribosomal protein L11
RPL5 ribosomal protein L5
RSAD2 radical S-adenosyl methionine domain containing 2
RSPO1 R-spondin 1
RUNX2 runt-related transcription factor 2
S100B S100 calcium binding protein B
SAMHD1 SAM domain and HD domain 1
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SENP1 SUMO1/sentrin specific peptidase 1
SH3PXD2A SH3 and PX domains 2A
SHH sonic hedgehog
SIRPA signal-regulatory protein alpha
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMO smoothened, frizzled class receptor
SNX3 sorting nexin 3
SOST sclerostin
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
SPIN1 spindlin 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STX16 syntaxin 16
STX6 syntaxin 6
TAAR6 trace amine associated receptor 6
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TARDBP TAR DNA binding protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TENM4 teneurin transmembrane protein 4
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
TJP1 tight junction protein 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TSC2 tuberous sclerosis 2
TUBA4A tubulin, alpha 4a
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VAMP4 vesicle-associated membrane protein 4
VIM vimentin
VTI1A vesicle transport through interaction with t-SNAREs 1A
WEE1 WEE1 G2 checkpoint kinase
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YAP1 Yes-associated protein 1
ZCCHC7 zinc finger, CCHC domain containing 7