disrupting Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

256 genes co-occuring with the biological term disrupting in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACO2 aconitase 2, mitochondrial
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAR adenosine deaminase, RNA-specific
ADORA2A adenosine A2a receptor
ADORA3 adenosine A3 receptor
ANGPT2 angiopoietin 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGAP26 Rho GTPase activating protein 26
ARSA arylsulfatase A
ASXL1 additional sex combs like transcriptional regulator 1
ATR ATR serine/threonine kinase
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BECN1 beclin 1, autophagy related
BID BH3 interacting domain death agonist
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BMPR1B bone morphogenetic protein receptor, type IB
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRAP BRCA1 associated protein
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTG3 BTG family, member 3
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CA9 carbonic anhydrase IX
CADPS2 Ca++-dependent secretion activator 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCAR2 cell cycle and apoptosis regulator 2
CCL22 chemokine (C-C motif) ligand 22
CD226 CD226 molecule
CD47 CD47 molecule
CDC25B cell division cycle 25B
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDX2 caudal type homeobox 2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHD7 chromodomain helicase DNA binding protein 7
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLDN4 claudin 4
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRBN cereblon
CRHR2 corticotropin releasing hormone receptor 2
CRYAA crystallin, alpha A
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSNK1A1 casein kinase 1, alpha 1
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAXX death-domain associated protein
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFA5 defensin, alpha 5, Paneth cell-specific
DES desmin
DICER1 dicer 1, ribonuclease type III
DISC1 disrupted in schizophrenia 1
DOT1L DOT1-like histone H3K79 methyltransferase
DRC1 dynein regulatory complex subunit 1
E2F1 E2F transcription factor 1
EGR1 early growth response 1
ERBB2IP erbb2 interacting protein
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR2 estrogen receptor 2 (ER beta)
EYS eyes shut homolog (Drosophila)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F10 coagulation factor X
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FANCF Fanconi anemia, complementation group F
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FLT1 fms-related tyrosine kinase 1
FRG1B FSHD region gene 1 family, member B
GLRA1 glycine receptor, alpha 1
GNAS GNAS complex locus
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNLY granulysin
GRB10 growth factor receptor-bound protein 10
HBG1 hemoglobin, gamma A
HDAC1 histone deacetylase 1
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DRA major histocompatibility complex, class II, DR alpha
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
IAPP islet amyloid polypeptide
ICOSLG inducible T-cell co-stimulator ligand
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNG interferon, gamma
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL1B interleukin 1, beta
IL4 interleukin 4
IL6 interleukin 6
INHBA inhibin, beta A
INSR insulin receptor
IRF3 interferon regulatory factor 3
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUN jun proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KDR kinase insert domain receptor
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT9 keratin 9, type I
L1CAM L1 cell adhesion molecule
LEP leptin
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
MAOA monoamine oxidase A
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MAVS mitochondrial antiviral signaling protein
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MIR125A microRNA 125a
MIR182 microRNA 182
MIR183 microRNA 183
MIR30B microRNA 30b
MIR573 microRNA 573
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPZ myelin protein zero
MSX1 msh homeobox 1
MSX2 msh homeobox 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC16 mucin 16, cell surface associated
MYBPC3 myosin binding protein C, cardiac
MYLK myosin light chain kinase
MYT1L myelin transcription factor 1-like
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NCOA1 nuclear receptor coactivator 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NF2 neurofibromin 2 (merlin)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLK nemo-like kinase
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR2E3 nuclear receptor subfamily 2, group E, member 3
NRG1 neuregulin 1
NRXN1 neurexin 1
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAGE4 P antigen family, member 4 (prostate associated)
PANK2 pantothenate kinase 2
PAX5 paired box 5
PCDH8 protocadherin 8
PCLO piccolo presynaptic cytomatrix protein
PF4 platelet factor 4
PHC3 polyhomeotic homolog 3 (Drosophila)
PIAS4 protein inhibitor of activated STAT, 4
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PMM2 phosphomannomutase 2
PNP purine nucleoside phosphorylase
POT1 protection of telomeres 1
POU2F1 POU class 2 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRB2 proline-rich protein BstNI subfamily 2
PRICKLE1 prickle homolog 1 (Drosophila)
PRKCE protein kinase C, epsilon
PRL prolactin
PRLR prolactin receptor
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRC protein tyrosine phosphatase, receptor type, C
PXDN peroxidasin
RAD50 RAD50 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALBP1 ralA binding protein 1
RAPSN receptor-associated protein of the synapse
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RHO rhodopsin
RPA2 replication protein A2, 32kDa
RSF1 remodeling and spacing factor 1
RUNX1 runt-related transcription factor 1
RXRA retinoid X receptor, alpha
RYR1 ryanodine receptor 1 (skeletal)
SCN1B sodium channel, voltage gated, type I beta subunit
SCRIB scribbled planar cell polarity protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SKI SKI proto-oncogene
SLC48A1 solute carrier family 48 (heme transporter), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SQSTM1 sequestosome 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYN1 synapsin I
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBK1 TANK-binding kinase 1
TBX2 T-box 2
TBX3 T-box 3
TBXA2R thromboxane A2 receptor
TDG thymine-DNA glycosylase
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TIGIT T cell immunoreceptor with Ig and ITIM domains
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR3 toll-like receptor 3
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53 tumor protein p53
TP63 tumor protein p63
TRAF1 TNF receptor-associated factor 1
TRAF4 TNF receptor-associated factor 4
TSG101 tumor susceptibility 101
TTK TTK protein kinase
TUBB1 tubulin, beta 1 class VI
UBASH3A ubiquitin associated and SH3 domain containing A
ULK1 unc-51 like autophagy activating kinase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VEGFA vascular endothelial growth factor A
VIM vimentin
WAS Wiskott-Aldrich syndrome
XAF1 XIAP associated factor 1
ZCCHC7 zinc finger, CCHC domain containing 7