disulfiram-2053 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the disulfiram-2053 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALOXE3 arachidonate lipoxygenase 3
ANKRD12 ankyrin repeat domain 12
APP amyloid beta (A4) precursor protein
ARC activity-regulated cytoskeleton-associated protein
ARG2 arginase 2
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASAP1-IT1 ASAP1 intronic transcript 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
CARS cysteinyl-tRNA synthetase
CASZ1 castor zinc finger 1
CCPG1 cell cycle progression 1
CLCN3 chloride channel, voltage-sensitive 3
CLK1 CDC-like kinase 1
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CTSZ cathepsin Z
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
EED embryonic ectoderm development
EGR1 early growth response 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FCF1 FCF1 rRNA-processing protein
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXA2 forkhead box A2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOOK1 hook microtubule-tethering protein 1
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
INSIG1 insulin induced gene 1
ISL1 ISL LIM homeobox 1
JUN jun proto-oncogene
KDM4C lysine (K)-specific demethylase 4C
KDM6A lysine (K)-specific demethylase 6A
MAN1A1 mannosidase, alpha, class 1A, member 1
MBNL2 muscleblind-like splicing regulator 2
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
NADK NAD kinase
NPM3 nucleophosmin/nucleoplasmin 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRXN3 neurexin 3
NXF1 nuclear RNA export factor 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PBX2 pre-B-cell leukemia homeobox 2
PCDHGA11 protocadherin gamma subfamily A, 11
PDE4DIP phosphodiesterase 4D interacting protein
PEX26 peroxisomal biogenesis factor 26
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTPRE protein tyrosine phosphatase, receptor type, E
RARA retinoic acid receptor, alpha
RRAD Ras-related associated with diabetes
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SKI SKI proto-oncogene
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP23 synaptosomal-associated protein, 23kDa
SQSTM1 sequestosome 1
SRCAP Snf2-related CREBBP activator protein
STX3 syntaxin 3
TBCD tubulin folding cofactor D
TLN2 talin 2
TMF1 TATA element modulatory factor 1
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2H ubiquitin-conjugating enzyme E2H
UGDH UDP-glucose 6-dehydrogenase
YOD1 YOD1 deubiquitinase
ZFAND5 zinc finger, AN1-type domain 5
ZFYVE9 zinc finger, FYVE domain containing 9
ZMYM2 zinc finger, MYM-type 2
ZNF10 zinc finger protein 10
ZNF770 zinc finger protein 770

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ANOS1 anosmin 1
ANXA2P3 annexin A2 pseudogene 3
APLP1 amyloid beta (A4) precursor-like protein 1
ARRB2 arrestin, beta 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BBS10 Bardet-Biedl syndrome 10
BORA bora, aurora kinase A activator
C1ORF56 chromosome 1 open reading frame 56
C4ORF19 chromosome 4 open reading frame 19
CCDC85C coiled-coil domain containing 85C
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CHMP6 charged multivesicular body protein 6
CNN2 calponin 2
CXCL2 chemokine (C-X-C motif) ligand 2
DNAL4 dynein, axonemal, light chain 4
FAM53B family with sequence similarity 53, member B
FBXO5 F-box protein 5
FLCN folliculin
FZD8 frizzled class receptor 8
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMIP GEM interacting protein
GRAMD1B GRAM domain containing 1B
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
H1FX H1 histone family, member X
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HJURP Holliday junction recognition protein
HMGB3 high mobility group box 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1B interleukin 1, beta
INF2 inverted formin, FH2 and WH2 domain containing
INHBB inhibin, beta B
INPPL1 inositol polyphosphate phosphatase-like 1
KDM5C lysine (K)-specific demethylase 5C
KIF3B kinesin family member 3B
KLHL12 kelch-like family member 12
KPTN kaptin (actin binding protein)
L2HGDH L-2-hydroxyglutarate dehydrogenase
LIF leukemia inhibitory factor
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEF1 melanoma antigen family F1
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL8 methyltransferase like 8
MXD3 MAX dimerization protein 3
MYBBP1A MYB binding protein (P160) 1a
NABP2 nucleic acid binding protein 2
NDE1 nudE neurodevelopment protein 1
NPR3 natriuretic peptide receptor 3
NUBP2 nucleotide binding protein 2
ORAI3 ORAI calcium release-activated calcium modulator 3
PALB2 partner and localizer of BRCA2
PARD6A par-6 family cell polarity regulator alpha
PCSK7 proprotein convertase subtilisin/kexin type 7
PHACTR4 phosphatase and actin regulator 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLK1 polo-like kinase 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPAP2B phosphatidic acid phosphatase type 2B
PRR15L proline rich 15-like
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSRC1 proline/serine-rich coiled-coil 1
PTK7 protein tyrosine kinase 7 (inactive)
RUNX1-IT1 RUNX1 intronic transcript 1
SH2B2 SH2B adaptor protein 2
SH2D2A SH2 domain containing 2A
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST5 suppression of tumorigenicity 5
TBC1D17 TBC1 domain family, member 17
THOP1 thimet oligopeptidase 1
TMEM109 transmembrane protein 109
TMOD3 tropomodulin 3 (ubiquitous)
TRIM16 tripartite motif containing 16
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TSPAN15 tetraspanin 15
UBTF upstream binding transcription factor, RNA polymerase I
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UNC119 unc-119 homolog (C. elegans)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC24 zinc finger, DHHC-type containing 24
ZFYVE16 zinc finger, FYVE domain containing 16
ZMAT5 zinc finger, matrin-type 5
ZNF160 zinc finger protein 160
ZNF264 zinc finger protein 264
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF91 zinc finger protein 91