dobutamine-1589 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the dobutamine-1589 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMBRA1 autophagy/beclin-1 regulator 1
ATP9B ATPase, class II, type 9B
AXL AXL receptor tyrosine kinase
BMP7 bone morphogenetic protein 7
BPI bactericidal/permeability-increasing protein
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CD38 CD38 molecule
CD86 CD86 molecule
CDCA3 cell division cycle associated 3
CIZ1 CDKN1A interacting zinc finger protein 1
CNTNAP1 contactin associated protein 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DOCK5 dedicator of cytokinesis 5
DSCR3 Down syndrome critical region 3
EGR2 early growth response 2
EGR3 early growth response 3
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ELF4 E74-like factor 4 (ets domain transcription factor)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERCC4 excision repair cross-complementation group 4
ETV5 ets variant 5
FAM76A family with sequence similarity 76, member A
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FLRT2 fibronectin leucine rich transmembrane protein 2
FPR1 formyl peptide receptor 1
FPR2 formyl peptide receptor 2
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GIMAP5 GTPase, IMAP family member 5
GLI3 GLI family zinc finger 3
GPNMB glycoprotein (transmembrane) nmb
GPR137 G protein-coupled receptor 137
GPR183 G protein-coupled receptor 183
GPR21 G protein-coupled receptor 21
GRK6 G protein-coupled receptor kinase 6
HFE hemochromatosis
HIST1H2BE histone cluster 1, H2be
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGSF6 immunoglobulin superfamily, member 6
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
IMPAD1 inositol monophosphatase domain containing 1
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KIFAP3 kinesin-associated protein 3
MBNL2 muscleblind-like splicing regulator 2
MST1 macrophage stimulating 1
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MX2 MX dynamin-like GTPase 2
MXRA8 matrix-remodelling associated 8
NELL2 NEL-like 2 (chicken)
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PADI2 peptidyl arginine deiminase, type II
PAQR3 progestin and adipoQ receptor family member III
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLSCR1 phospholipid scramblase 1
PPAP2A phosphatidic acid phosphatase type 2A
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PVR poliovirus receptor
RABIF RAB interacting factor
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS13 regulator of G-protein signaling 13
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF19B ring finger protein 19B
RWDD3 RWD domain containing 3
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SF3A2 splicing factor 3a, subunit 2, 66kDa
SH2D2A SH2 domain containing 2A
SIDT2 SID1 transmembrane family, member 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SMAD7 SMAD family member 7
SMOX spermine oxidase
SNX11 sorting nexin 11
SPN sialophorin
THTPA thiamine triphosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TRIM26 tripartite motif containing 26
TULP3 tubby like protein 3
WSB1 WD repeat and SOCS box containing 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF443 zinc finger protein 443

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ABT1 activator of basal transcription 1
ACP2 acid phosphatase 2, lysosomal
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADGRA2 adhesion G protein-coupled receptor A2
AHCTF1 AT hook containing transcription factor 1
BCCIP BRCA2 and CDKN1A interacting protein
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BYSL bystin-like
C8ORF33 chromosome 8 open reading frame 33
CCNA1 cyclin A1
CDK7 cyclin-dependent kinase 7
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHST10 carbohydrate sulfotransferase 10
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CORO2A coronin, actin binding protein, 2A
CPNE1 copine I
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DAAM1 dishevelled associated activator of morphogenesis 1
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DOLK dolichol kinase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELANE elastase, neutrophil expressed
ERCC2 excision repair cross-complementation group 2
ETV6 ets variant 6
EXOSC5 exosome component 5
FLT3 fms-related tyrosine kinase 3
FPGS folylpolyglutamate synthase
GEMIN6 gem (nuclear organelle) associated protein 6
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPATCH3 G patch domain containing 3
GPR27 G protein-coupled receptor 27
GRM6 glutamate receptor, metabotropic 6
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HAL histidine ammonia-lyase
HSPA4L heat shock 70kDa protein 4-like
HSPB1 heat shock 27kDa protein 1
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IFITM3 interferon induced transmembrane protein 3
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INO80D INO80 complex subunit D
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0020 KIAA0020
LAMP5 lysosomal-associated membrane protein family, member 5
LAS1L LAS1-like (S. cerevisiae)
LIAS lipoic acid synthetase
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRP3 low density lipoprotein receptor-related protein 3
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAK16 MAK16 homolog (S. cerevisiae)
MATK megakaryocyte-associated tyrosine kinase
MCM3AP-AS1 MCM3AP antisense RNA 1
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MOSPD3 motile sperm domain containing 3
MRPL12 mitochondrial ribosomal protein L12
MRPS34 mitochondrial ribosomal protein S34
MYBBP1A MYB binding protein (P160) 1a
NABP2 nucleic acid binding protein 2
NME3 NME/NM23 nucleoside diphosphate kinase 3
NUP93 nucleoporin 93kDa
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PANK4 pantothenate kinase 4
PCOLCE2 procollagen C-endopeptidase enhancer 2
PES1 pescadillo ribosomal biogenesis factor 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PUS1 pseudouridylate synthase 1
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RFPL3 ret finger protein-like 3
RPS21 ribosomal protein S21
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RUVBL1 RuvB-like AAA ATPase 1
SAC3D1 SAC3 domain containing 1
SETD8 SET domain containing (lysine methyltransferase) 8
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLIRP SRA stem-loop interacting RNA binding protein
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
STK25 serine/threonine kinase 25
SYNGR2 synaptogyrin 2
TFB2M transcription factor B2, mitochondrial
THAP7 THAP domain containing 7
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)
TMEM33 transmembrane protein 33
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TTC4 tetratricopeptide repeat domain 4
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
WDR18 WD repeat domain 18
WDR46 WD repeat domain 46