dobutamine-5386 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the dobutamine-5386 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACTG2 actin, gamma 2, smooth muscle, enteric
AGBL2 ATP/GTP binding protein-like 2
ANXA2P3 annexin A2 pseudogene 3
APOC1 apolipoprotein C-I
APP amyloid beta (A4) precursor protein
ARHGAP4 Rho GTPase activating protein 4
ARTN artemin
ASIC1 acid sensing (proton gated) ion channel 1
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C14ORF79 chromosome 14 open reading frame 79
C1ORF54 chromosome 1 open reading frame 54
C1QTNF1 C1q and tumor necrosis factor related protein 1
C3 complement component 3
C8ORF44 chromosome 8 open reading frame 44
CCDC71 coiled-coil domain containing 71
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEND1 cell cycle exit and neuronal differentiation 1
CETN1 centrin, EF-hand protein, 1
CLDN18 claudin 18
COLEC12 collectin sub-family member 12
CRHR1 corticotropin releasing hormone receptor 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DICER1 dicer 1, ribonuclease type III
DIO2 deiodinase, iodothyronine, type II
DMXL2 Dmx-like 2
DUSP6 dual specificity phosphatase 6
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFR3B EFR3 homolog B (S. cerevisiae)
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
F13B coagulation factor XIII, B polypeptide
FAIM2 Fas apoptotic inhibitory molecule 2
FGF23 fibroblast growth factor 23
FGL1 fibrinogen-like 1
FHL5 four and a half LIM domains 5
FLOT1 flotillin 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPR137 G protein-coupled receptor 137
GPR27 G protein-coupled receptor 27
GTDC1 glycosyltransferase-like domain containing 1
HIST1H1T histone cluster 1, H1t
HNF1B HNF1 homeobox B
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1324 KIAA1324
KLHL25 kelch-like family member 25
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LHX3 LIM homeobox 3
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAPK7 mitogen-activated protein kinase 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2D myocyte enhancer factor 2D
MKL1 megakaryoblastic leukemia (translocation) 1
MPZ myelin protein zero
NF1 neurofibromin 1
NOS1 nitric oxide synthase 1 (neuronal)
NPC1 Niemann-Pick disease, type C1
NPR3 natriuretic peptide receptor 3
NT5E 5'-nucleotidase, ecto (CD73)
NXPH4 neurexophilin 4
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PCDH7 protocadherin 7
PCDHB6 protocadherin beta 6
PGAP3 post-GPI attachment to proteins 3
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD1 phospholipase D1, phosphatidylcholine-specific
POMT2 protein-O-mannosyltransferase 2
POPDC3 popeye domain containing 3
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRF1 perforin 1 (pore forming protein)
RAB14 RAB14, member RAS oncogene family
RIMS2 regulating synaptic membrane exocytosis 2
SAFB scaffold attachment factor B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A14 solute carrier family 22, member 14
SPDEF SAM pointed domain containing ETS transcription factor
STMN3 stathmin-like 3
TAC3 tachykinin 3
TAS2R10 taste receptor, type 2, member 10
TBC1D2 TBC1 domain family, member 2
TBXA2R thromboxane A2 receptor
THNSL2 threonine synthase-like 2 (S. cerevisiae)
THRA thyroid hormone receptor, alpha
TM4SF5 transmembrane 4 L six family member 5
TMEM8B transmembrane protein 8B
TPMT thiopurine S-methyltransferase
TTC38 tetratricopeptide repeat domain 38

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALPK1 alpha-kinase 1
APLP1 amyloid beta (A4) precursor-like protein 1
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BST2 bone marrow stromal cell antigen 2
C11ORF80 chromosome 11 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C5ORF45 chromosome 5 open reading frame 45
CAPN15 calpain 15
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD302 CD302 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD8A CD8a molecule
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CENPQ centromere protein Q
CES3 carboxylesterase 3
CLIC2 chloride intracellular channel 2
CRIP1 cysteine-rich protein 1 (intestinal)
CUZD1 CUB and zona pellucida-like domains 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DET1 de-etiolated homolog 1 (Arabidopsis)
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ELOVL2 ELOVL fatty acid elongase 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM120C family with sequence similarity 120C
FAM46C family with sequence similarity 46, member C
FBXL6 F-box and leucine-rich repeat protein 6
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR19 G protein-coupled receptor 19
GRTP1 growth hormone regulated TBC protein 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HOXC5 homeobox C5
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP6 insulin-like growth factor binding protein 6
IGSF1 immunoglobulin superfamily, member 1
KIAA0319L KIAA0319-like
KLHL12 kelch-like family member 12
LRRC61 leucine rich repeat containing 61
MBTD1 mbt domain containing 1
MDM4 MDM4, p53 regulator
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTERF4 mitochondrial transcription termination factor 4
MYOZ3 myozenin 3
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NKX3-2 NK3 homeobox 2
OLFML2A olfactomedin-like 2A
PDE12 phosphodiesterase 12
PNPLA6 patatin-like phospholipase domain containing 6
PRR4 proline rich 4 (lacrimal)
QPCT glutaminyl-peptide cyclotransferase
QSER1 glutamine and serine rich 1
RCAN3 RCAN family member 3
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RPGRIP1L RPGRIP1-like
RPL13P5 ribosomal protein L13 pseudogene 5
RPL23AP32 ribosomal protein L23a pseudogene 32
SCAI suppressor of cancer cell invasion
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SETD8 SET domain containing (lysine methyltransferase) 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLIT2 slit homolog 2 (Drosophila)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SND1-IT1 SND1 intronic transcript 1
SPINK5 serine peptidase inhibitor, Kazal type 5
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TGFBR3 transforming growth factor, beta receptor III
TMEM209 transmembrane protein 209
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTBK2 tau tubulin kinase 2
VGF VGF nerve growth factor inducible
WFDC2 WAP four-disulfide core domain 2
ZBTB44 zinc finger and BTB domain containing 44
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF141 zinc finger protein 141
ZNF551 zinc finger protein 551
ZNF804A zinc finger protein 804A