doxifluridine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase. (Chemical Entities of Biological Interest Ontology, CHEBI_31521)
External Link http://ctdbase.org/detail.go?type=chem&acc=C025034
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Genes

49 genes/proteins interacting with the chemical doxifluridine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
AGR2 anterior gradient 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ANXA8 annexin A8
ARL4D ADP-ribosylation factor-like 4D
AXL AXL receptor tyrosine kinase
CIB1 calcium and integrin binding 1 (calmyrin)
CLDN3 claudin 3
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK1 death-associated protein kinase 1
DPYD dihydropyrimidine dehydrogenase
DSE dermatan sulfate epimerase
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK1 ethanolamine kinase 1
FAM60A family with sequence similarity 60, member A
FHL1 four and a half LIM domains 1
FLII flightless I homolog (Drosophila)
FUCA1 fucosidase, alpha-L- 1, tissue
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRAS Harvey rat sarcoma viral oncogene homolog
ICAM3 intercellular adhesion molecule 3
IFNG interferon, gamma
IL17RB interleukin 17 receptor B
LGALS4 lectin, galactoside-binding, soluble, 4
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MYB v-myb avian myeloblastosis viral oncogene homolog
NME7 NME/NM23 family member 7
OSMR oncostatin M receptor
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKP2 plakophilin 2
PLCE1 phospholipase C, epsilon 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PYGB phosphorylase, glycogen; brain
RAB40B RAB40B, member RAS oncogene family
RPA1 replication protein A1, 70kDa
RRAS2 related RAS viral (r-ras) oncogene homolog 2
STIP1 stress-induced phosphoprotein 1
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TNF tumor necrosis factor
TYMP thymidine phosphorylase
TYMS thymidylate synthetase
UPP1 uridine phosphorylase 1