doxorubicin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An anthracycline antibiotic that has formula C27H29NO11. (Chemical Entities of Biological Interest Ontology, CHEBI_28748)
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Genes

119 genes co-occuring with the biological term doxorubicin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATG5 autophagy related 5
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL6 B-cell CLL/lymphoma 6
BECN1 beclin 1, autophagy related
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFLAR CASP8 and FADD-like apoptosis regulator
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DEPTOR DEP domain containing MTOR-interacting protein
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTYMK deoxythymidylate kinase (thymidylate kinase)
E2F1 E2F transcription factor 1
ELAVL1 ELAV like RNA binding protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAS Fas cell surface death receptor
FBXO5 F-box protein 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FOXO3 forkhead box O3
GDF15 growth differentiation factor 15
GSTA1 glutathione S-transferase alpha 1
GSTP1 glutathione S-transferase pi 1
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNF4A hepatocyte nuclear factor 4, alpha
HSF1 heat shock transcription factor 1
IFNB1 interferon, beta 1, fibroblast
IL6 interleukin 6
IRF4 interferon regulatory factor 4
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
LDHA lactate dehydrogenase A
LIG4 ligase IV, DNA, ATP-dependent
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCM3 minichromosome maintenance complex component 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFN2 mitofusin 2
MIR137 microRNA 137
MIR200C microRNA 200c
MIR205 microRNA 205
MIR21 microRNA 21
MIR221 microRNA 221
MIR298 microRNA 298
MIR520H microRNA 520h
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MT2A metallothionein 2A
MUC16 mucin 16, cell surface associated
NANOG Nanog homeobox
NEK2 NIMA-related kinase 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH1 notch 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NRP1 neuropilin 1
NTN1 netrin 1
NUAK2 NUAK family, SNF1-like kinase, 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKCA protein kinase C, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD51 RAD51 recombinase
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALBP1 ralA binding protein 1
RBM17 RNA binding motif protein 17
REPS1 RALBP1 associated Eps domain containing 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SDC2 syndecan 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SGPP1 sphingosine-1-phosphate phosphatase 1
SIRT1 sirtuin 1
SIRT4 sirtuin 4
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNNI3 troponin I type 3 (cardiac)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
UHRF1 ubiquitin-like with PHD and ring finger domains 1
VCAN versican
VEGFA vascular endothelial growth factor A
VIM vimentin
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
VRK1 vaccinia related kinase 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1