doxycycline-1113 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the doxycycline-1113 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABR active BCR-related
AGGF1 angiogenic factor with G patch and FHA domains 1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANKRD12 ankyrin repeat domain 12
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARL1 ADP-ribosylation factor-like 1
ATP13A3 ATPase type 13A3
BAX BCL2-associated X protein
BCL3 B-cell CLL/lymphoma 3
C1ORF106 chromosome 1 open reading frame 106
C2ORF44 chromosome 2 open reading frame 44
CCDC91 coiled-coil domain containing 91
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDR2L cerebellar degeneration-related protein 2-like
CEP63 centrosomal protein 63kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COQ6 coenzyme Q6 monooxygenase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIAPH1 diaphanous-related formin 1
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DUS4L dihydrouridine synthase 4-like (S. cerevisiae)
EFCAB2 EF-hand calcium binding domain 2
EGR3 early growth response 3
FHL1 four and a half LIM domains 1
FXR2 fragile X mental retardation, autosomal homolog 2
GATAD2A GATA zinc finger domain containing 2A
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HN1L hematological and neurological expressed 1-like
HPS4 Hermansky-Pudlak syndrome 4
IFNAR2 interferon (alpha, beta and omega) receptor 2
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
JMJD1C jumonji domain containing 1C
JRK Jrk homolog (mouse)
KAT6B K(lysine) acetyltransferase 6B
KIF1C kinesin family member 1C
KLF6 Kruppel-like factor 6
KLHL36 kelch-like family member 36
MAP6D1 MAP6 domain containing 1
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL5 methyltransferase like 5
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MOB1A MOB kinase activator 1A
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MUC1 mucin 1, cell surface associated
MVK mevalonate kinase
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NAGLU N-acetylglucosaminidase, alpha
NPM3 nucleophosmin/nucleoplasmin 3
NSFL1C NSFL1 (p97) cofactor (p47)
NUMB numb homolog (Drosophila)
OSBPL1A oxysterol binding protein-like 1A
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAQR6 progestin and adipoQ receptor family member VI
PC pyruvate carboxylase
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PEX10 peroxisomal biogenesis factor 10
PEX16 peroxisomal biogenesis factor 16
PEX26 peroxisomal biogenesis factor 26
PHF20L1 PHD finger protein 20-like 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKCSH protein kinase C substrate 80K-H
RAD23A RAD23 homolog A (S. cerevisiae)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RPL37A ribosomal protein L37a
RUFY3 RUN and FYVE domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SHARPIN SHANK-associated RH domain interactor
SIGMAR1 sigma non-opioid intracellular receptor 1
SIKE1 suppressor of IKBKE 1
SMC2 structural maintenance of chromosomes 2
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SNX13 sorting nexin 13
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TFIP11 tuftelin interacting protein 11
TMCO6 transmembrane and coiled-coil domains 6
TWF1 twinfilin actin binding protein 1
USP6NL USP6 N-terminal like
ZBTB40 zinc finger and BTB domain containing 40
ZNF318 zinc finger protein 318
ZNF675 zinc finger protein 675
ZNF787 zinc finger protein 787

decreased expression

Symbol Name
ANO10 anoctamin 10
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCAS3 breast carcinoma amplified sequence 3
BPHL biphenyl hydrolase-like (serine hydrolase)
C16ORF58 chromosome 16 open reading frame 58
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C2CD5 C2 calcium-dependent domain containing 5
C5ORF28 chromosome 5 open reading frame 28
CCDC170 coiled-coil domain containing 170
CCNT1 cyclin T1
CCSER2 coiled-coil serine-rich protein 2
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK9 cyclin-dependent kinase 9
CLDN4 claudin 4
COCH cochlin
COG4 component of oligomeric golgi complex 4
CSAD cysteine sulfinic acid decarboxylase
CTSD cathepsin D
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
ELP3 elongator acetyltransferase complex subunit 3
FAM193B family with sequence similarity 193, member B
FOCAD focadhesin
FYCO1 FYVE and coiled-coil domain containing 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GTF2I general transcription factor IIi
HAUS4 HAUS augmin-like complex, subunit 4
HINFP histone H4 transcription factor
HIST1H2BI histone cluster 1, H2bi
IER3IP1 immediate early response 3 interacting protein 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
ING3 inhibitor of growth family, member 3
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIF15 kinesin family member 15
KLF3 Kruppel-like factor 3 (basic)
LIMA1 LIM domain and actin binding 1
MANSC1 MANSC domain containing 1
MED18 mediator complex subunit 18
MGMT O-6-methylguanine-DNA methyltransferase
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MPZL2 myelin protein zero-like 2
MTCH1 mitochondrial carrier 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NUP153 nucleoporin 153kDa
NXN nucleoredoxin
OCLN occludin
PEX13 peroxisomal biogenesis factor 13
PFAS phosphoribosylformylglycinamidine synthase
PHF11 PHD finger protein 11
PHLDA3 pleckstrin homology-like domain, family A, member 3
POTEKP POTE ankyrin domain family, member K, pseudogene
PP14571 uncharacterized LOC100130449
PUS3 pseudouridylate synthase 3
QPRT quinolinate phosphoribosyltransferase
RAB13 RAB13, member RAS oncogene family
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RGS19 regulator of G-protein signaling 19
RINT1 RAD50 interactor 1
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RNF25 ring finger protein 25
RPL23AP7 ribosomal protein L23a pseudogene 7
RPL36 ribosomal protein L36
RPUSD2 RNA pseudouridylate synthase domain containing 2
RWDD2A RWD domain containing 2A
SAMHD1 SAM domain and HD domain 1
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SETD6 SET domain containing 6
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC16A6 solute carrier family 16, member 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SRSF8 serine/arginine-rich splicing factor 8
SYNGR3 synaptogyrin 3
TBC1D31 TBC1 domain family, member 31
TIMP2 TIMP metallopeptidase inhibitor 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM110 transmembrane protein 110
TMEM51 transmembrane protein 51
TRIM52 tripartite motif containing 52
TXNRD1 thioredoxin reductase 1
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
WRN Werner syndrome, RecQ helicase-like
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YAP1 Yes-associated protein 1
ZBTB24 zinc finger and BTB domain containing 24
ZC3H7A zinc finger CCCH-type containing 7A
ZCCHC8 zinc finger, CCHC domain containing 8
ZDHHC4 zinc finger, DHHC-type containing 4
ZFAND3 zinc finger, AN1-type domain 3
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZMAT5 zinc finger, matrin-type 5
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF654 zinc finger protein 654
ZNF665 zinc finger protein 665