doxycycline-2737 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the doxycycline-2737 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADGB androglobin
ADRA1A adrenoceptor alpha 1A
AMACR alpha-methylacyl-CoA racemase
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ART4 ADP-ribosyltransferase 4 (Dombrock blood group)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C14ORF105 chromosome 14 open reading frame 105
C3ORF36 chromosome 3 open reading frame 36
C7ORF69 chromosome 7 open reading frame 69
CALD1 caldesmon 1
CD6 CD6 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFB complement factor B
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLDN3 claudin 3
CLEC10A C-type lectin domain family 10, member A
COL19A1 collagen, type XIX, alpha 1
COL8A2 collagen, type VIII, alpha 2
CST1 cystatin SN
CTAG2 cancer/testis antigen 2
CTSE cathepsin E
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOCK6 dedicator of cytokinesis 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FGFR2 fibroblast growth factor receptor 2
FLJ11292
FLT3LG fms-related tyrosine kinase 3 ligand
FOSL2 FOS-like antigen 2
FPR1 formyl peptide receptor 1
FRMPD1 FERM and PDZ domain containing 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GSTA3 glutathione S-transferase alpha 3
GUCA2A guanylate cyclase activator 2A (guanylin)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAMP hepcidin antimicrobial peptide
HEG1 heart development protein with EGF-like domains 1
HIST1H2BN histone cluster 1, H2bn
HOXA6 homeobox A6
IBSP integrin-binding sialoprotein
IGH immunoglobulin heavy locus
IL2 interleukin 2
IL33R interleukin 33 receptor
INS insulin
INSR insulin receptor
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KRT31 keratin 31, type I
KSR1 kinase suppressor of ras 1
LAMA4 laminin, alpha 4
LMF1 lipase maturation factor 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MRPS18C mitochondrial ribosomal protein S18C
MTSS1L metastasis suppressor 1-like
NHLH2 nescient helix loop helix 2
NLGN1 neuroligin 1
NRG1 neuregulin 1
OLFM4 olfactomedin 4
PADI4 peptidyl arginine deiminase, type IV
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDLIM5 PDZ and LIM domain 5
PKP3 plakophilin 3
PLAT plasminogen activator, tissue
PLCH1 phospholipase C, eta 1
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAPSN receptor-associated protein of the synapse
SCN2B sodium channel, voltage gated, type II beta subunit
SFTPA2 surfactant protein A2
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMR3B submaxillary gland androgen regulated protein 3B
SOX2 SRY (sex determining region Y)-box 2
SPAG8 sperm associated antigen 8
SPRR1A small proline-rich protein 1A
SYT5 synaptotagmin V
TGFB1 transforming growth factor, beta 1
THPO thrombopoietin
TMEM212 transmembrane protein 212
TRIM31 tripartite motif containing 31
TRIO trio Rho guanine nucleotide exchange factor
TRO trophinin
TRPC4 transient receptor potential cation channel, subfamily C, member 4
ZBTB7B zinc finger and BTB domain containing 7B
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMDHD2 amidohydrolase domain containing 2
ARG1 arginase 1
ASNSD1 asparagine synthetase domain containing 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BTBD18 BTB (POZ) domain containing 18
C8ORF44 chromosome 8 open reading frame 44
CAMKMT calmodulin-lysine N-methyltransferase
CCDC132 coiled-coil domain containing 132
CCDC57 coiled-coil domain containing 57
CCDC71 coiled-coil domain containing 71
CCDC85C coiled-coil domain containing 85C
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CEP295 centrosomal protein 295kDa
CEP97 centrosomal protein 97kDa
CHM choroideremia (Rab escort protein 1)
CHMP6 charged multivesicular body protein 6
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CRYGC crystallin, gamma C
DCAF13 DDB1 and CUL4 associated factor 13
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DHRS11 dehydrogenase/reductase (SDR family) member 11
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFNA3 ephrin-A3
EMILIN2 elastin microfibril interfacer 2
EML4 echinoderm microtubule associated protein like 4
ERO1LB ERO1-like beta (S. cerevisiae)
FKBP9 FK506 binding protein 9, 63 kDa
FOXN2 forkhead box N2
GBP2 guanylate binding protein 2, interferon-inducible
GID4 GID complex subunit 4
GK3P glycerol kinase 3 pseudogene
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR22 G protein-coupled receptor 22
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INCENP inner centromere protein antigens 135/155kDa
INF2 inverted formin, FH2 and WH2 domain containing
INPP1 inositol polyphosphate-1-phosphatase
KIF23 kinesin family member 23
KIF3C kinesin family member 3C
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LTBP3 latent transforming growth factor beta binding protein 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MLPH melanophilin
MNS1 meiosis-specific nuclear structural 1
MOCS3 molybdenum cofactor synthesis 3
MRPL44 mitochondrial ribosomal protein L44
MYOZ3 myozenin 3
NFE2L3 nuclear factor, erythroid 2-like 3
NOD1 nucleotide-binding oligomerization domain containing 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PADI2 peptidyl arginine deiminase, type II
PCDHGA8 protocadherin gamma subfamily A, 8
PIR pirin (iron-binding nuclear protein)
PLD3 phospholipase D family, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PODXL2 podocalyxin-like 2
POLM polymerase (DNA directed), mu
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOH ras homolog family member H
RNF122 ring finger protein 122
RRAGB Ras-related GTP binding B
RWDD3 RWD domain containing 3
SCG5 secretogranin V
SERINC5 serine incorporator 5
SH2D4A SH2 domain containing 4A
SKA1 spindle and kinetochore associated complex subunit 1
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC38A6 solute carrier family 38, member 6
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
STX11 syntaxin 11
STX1A syntaxin 1A (brain)
SYNJ2BP synaptojanin 2 binding protein
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TPM3 tropomyosin 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D4 TSC22 domain family, member 4
TTC23 tetratricopeptide repeat domain 23
TXLNG taxilin gamma
ULK1 unc-51 like autophagy activating kinase 1
UPK3A uroplakin 3A
VN1R1 vomeronasal 1 receptor 1
WDR62 WD repeat domain 62
ZNF225 zinc finger protein 225
ZNF276 zinc finger protein 276
ZNF34 zinc finger protein 34
ZNF492 zinc finger protein 492
ZNF510 zinc finger protein 510
ZNF668 zinc finger protein 668
ZNF787 zinc finger protein 787
ZNHIT2 zinc finger, HIT-type containing 2