doxycycline-7195 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the doxycycline-7195 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAM17 ADAM metallopeptidase domain 17
ADAM23 ADAM metallopeptidase domain 23
AFF4 AF4/FMR2 family, member 4
AKR1C4 aldo-keto reductase family 1, member C4
AVL9 AVL9 homolog (S. cerevisiase)
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTBD7 BTB (POZ) domain containing 7
C10ORF95 chromosome 10 open reading frame 95
C17ORF80 chromosome 17 open reading frame 80
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAPN10 calpain 10
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CFLAR CASP8 and FADD-like apoptosis regulator
COL7A1 collagen, type VII, alpha 1
CREM cAMP responsive element modulator
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTIF CBP80/20-dependent translation initiation factor
DIAPH2 diaphanous-related formin 2
DOHH deoxyhypusine hydroxylase/monooxygenase
DUSP10 dual specificity phosphatase 10
DXO decapping exoribonuclease
EFNA3 ephrin-A3
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EMC1 ER membrane protein complex subunit 1
ESR1 estrogen receptor 1
EXOC5 exocyst complex component 5
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLRX glutaredoxin (thioltransferase)
GMEB1 glucocorticoid modulatory element binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
INTS6 integrator complex subunit 6
KAZN kazrin, periplakin interacting protein
KIAA0930 KIAA0930
LMAN1 lectin, mannose-binding, 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MARK4 MAP/microtubule affinity-regulating kinase 4
MARS methionyl-tRNA synthetase
MID2 midline 2
MPPE1 metallophosphoesterase 1
MST1 macrophage stimulating 1
NCAPH2 non-SMC condensin II complex, subunit H2
NF2 neurofibromin 2 (merlin)
NRSN2 neurensin 2
OTUD4 OTU deubiquitinase 4
PARD6B par-6 family cell polarity regulator beta
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFB platelet-derived growth factor beta polypeptide
PFDN6 prefoldin subunit 6
PIBF1 progesterone immunomodulatory binding factor 1
POT1 protection of telomeres 1
PRKCH protein kinase C, eta
PRKD3 protein kinase D3
PRODH proline dehydrogenase (oxidase) 1
QKI QKI, KH domain containing, RNA binding
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCAN1 regulator of calcineurin 1
RER1 retention in endoplasmic reticulum sorting receptor 1
RNFT1 ring finger protein, transmembrane 1
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SAFB2 scaffold attachment factor B2
SAMD9 sterile alpha motif domain containing 9
SCAI suppressor of cancer cell invasion
SCAPER S-phase cyclin A-associated protein in the ER
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLIT2 slit homolog 2 (Drosophila)
SLK STE20-like kinase
SNORA21 small nucleolar RNA, H/ACA box 21
SNX1 sorting nexin 1
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SP100 SP100 nuclear antigen
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SS18 synovial sarcoma translocation, chromosome 18
SVIL supervillin
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
THAP1 THAP domain containing, apoptosis associated protein 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN3 tetraspanin 3
WAS Wiskott-Aldrich syndrome
WDTC1 WD and tetratricopeptide repeats 1
ZNF407 zinc finger protein 407
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ALS2CL ALS2 C-terminal like
ARSB arylsulfatase B
BAK1 BCL2-antagonist/killer 1
BCL9 B-cell CLL/lymphoma 9
BTF3P12 basic transcription factor 3 pseudogene 12
C16ORF59 chromosome 16 open reading frame 59
C5 complement component 5
CD82 CD82 molecule
CENPO centromere protein O
CEP85 centrosomal protein 85kDa
CHKB choline kinase beta
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CTAGE9 CTAGE family, member 9
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DGAT1 diacylglycerol O-acyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSPP dentin sialophosphoprotein
DUSP8 dual specificity phosphatase 8
ELMO3 engulfment and cell motility 3
FAM193B family with sequence similarity 193, member B
FAM86C1 family with sequence similarity 86, member C1
FEM1C fem-1 homolog c (C. elegans)
GAN gigaxonin
GLI3 GLI family zinc finger 3
GLTSCR1 glioma tumor suppressor candidate region gene 1
GOLGA3 golgin A3
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
IRF2BP1 interferon regulatory factor 2 binding protein 1
JMJD4 jumonji domain containing 4
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA0319L KIAA0319-like
KPTN kaptin (actin binding protein)
KRT31 keratin 31, type I
LIN7B lin-7 homolog B (C. elegans)
MAP1S microtubule-associated protein 1S
MAPK12 mitogen-activated protein kinase 12
MAST3 microtubule associated serine/threonine kinase 3
MED24 mediator complex subunit 24
MITF microphthalmia-associated transcription factor
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP9 matrix metallopeptidase 9
MXD3 MAX dimerization protein 3
NCAM2 neural cell adhesion molecule 2
NES nestin
NOL6 nucleolar protein 6 (RNA-associated)
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PARP16 poly (ADP-ribose) polymerase family, member 16
PCSK7 proprotein convertase subtilisin/kexin type 7
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PELI1 pellino E3 ubiquitin protein ligase 1
PGP phosphoglycolate phosphatase
PLA2G15 phospholipase A2, group XV
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRICKLE3 prickle homolog 3 (Drosophila)
PTCD2 pentatricopeptide repeat domain 2
PTDSS2 phosphatidylserine synthase 2
PYCRL pyrroline-5-carboxylate reductase-like
RANGRF RAN guanine nucleotide release factor
RNF25 ring finger protein 25
RNF31 ring finger protein 31
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
SIL1 SIL1 nucleotide exchange factor
SIRT6 sirtuin 6
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC41A3 solute carrier family 41, member 3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
THBS3 thrombospondin 3
TICAM1 toll-like receptor adaptor molecule 1
TLR5 toll-like receptor 5
TMC5 transmembrane channel-like 5
TMEM180 transmembrane protein 180
TMEM51 transmembrane protein 51
TOM1 target of myb1 (chicken)
TPCN1 two pore segment channel 1
TRABD TraB domain containing
TRAF2 TNF receptor-associated factor 2
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPAN14 tetraspanin 14
TTC30A tetratricopeptide repeat domain 30A
TUBA3C tubulin, alpha 3c
TUBGCP5 tubulin, gamma complex associated protein 5
USP27X ubiquitin specific peptidase 27, X-linked
VAV1 vav 1 guanine nucleotide exchange factor
VGF VGF nerve growth factor inducible
VPS9D1 VPS9 domain containing 1
WDR60 WD repeat domain 60
ZBED8 zinc finger, BED-type containing 8
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC18 zinc finger, DHHC-type containing 18
ZFP30 ZFP30 zinc finger protein
ZNF480 zinc finger protein 480