doxylamine-1473 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the doxylamine-1473 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
AAMDC adipogenesis associated, Mth938 domain containing
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALPK1 alpha-kinase 1
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APP amyloid beta (A4) precursor protein
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP33 Rho GTPase activating protein 33
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ASB1 ankyrin repeat and SOCS box containing 1
ATG13 autophagy related 13
BAHCC1 BAH domain and coiled-coil containing 1
BICD2 bicaudal D homolog 2 (Drosophila)
BMP8B bone morphogenetic protein 8b
C5AR2 complement component 5a receptor 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC85C coiled-coil domain containing 85C
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CFHR4 complement factor H-related 4
CIB2 calcium and integrin binding family member 2
CLCF1 cardiotrophin-like cytokine factor 1
CPB1 carboxypeptidase B1 (tissue)
CRLF1 cytokine receptor-like factor 1
CRTC1 CREB regulated transcription coactivator 1
CUZD1 CUB and zona pellucida-like domains 1
CYHR1 cysteine/histidine-rich 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DFNB31 deafness, autosomal recessive 31
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EDNRA endothelin receptor type A
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EMC1 ER membrane protein complex subunit 1
ENGASE endo-beta-N-acetylglucosaminidase
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHB2 EPH receptor B2
ETNK2 ethanolamine kinase 2
FBXL7 F-box and leucine-rich repeat protein 7
FBXO4 F-box protein 4
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GLB1L galactosidase, beta 1-like
GOSR2 golgi SNAP receptor complex member 2
HAMP hepcidin antimicrobial peptide
HBEGF heparin-binding EGF-like growth factor
HDAC11 histone deacetylase 11
HFE hemochromatosis
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IGFBP5 insulin-like growth factor binding protein 5
IPW imprinted in Prader-Willi syndrome (non-protein coding)
IRS2 insulin receptor substrate 2
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LMAN1 lectin, mannose-binding, 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MRPL41 mitochondrial ribosomal protein L41
NDRG2 NDRG family member 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NLGN4X neuroligin 4, X-linked
NOAZFP nucleolar atypical zinc finger
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAZ3 ornithine decarboxylase antizyme 3
OSGIN2 oxidative stress induced growth inhibitor family member 2
PGAP3 post-GPI attachment to proteins 3
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PKNOX1 PBX/knotted 1 homeobox 1
POFUT1 protein O-fucosyltransferase 1
POU3F4 POU class 3 homeobox 4
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RAB6A RAB6A, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RER1 retention in endoplasmic reticulum sorting receptor 1
RNF170 ring finger protein 170
SHANK1 SH3 and multiple ankyrin repeat domains 1
SIGLEC6 sialic acid binding Ig-like lectin 6
SMAD3 SMAD family member 3
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SPTBN1 spectrin, beta, non-erythrocytic 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYT5 synaptotagmin V
TERT telomerase reverse transcriptase
TLE2 transducin-like enhancer of split 2
TMC6 transmembrane channel-like 6
TMCC2 transmembrane and coiled-coil domain family 2
TMEM242 transmembrane protein 242
TRIM5 tripartite motif containing 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
USP34 ubiquitin specific peptidase 34
WNT16 wingless-type MMTV integration site family, member 16
ZNF227 zinc finger protein 227
ZNF365 zinc finger protein 365
ZNF419 zinc finger protein 419

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACSF2 acyl-CoA synthetase family member 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ACVR2A activin A receptor, type IIA
ADM adrenomedullin
AGO1 argonaute RISC catalytic component 1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARMC6 armadillo repeat containing 6
ARRB1 arrestin, beta 1
ATF3 activating transcription factor 3
BCL2L2 BCL2-like 2
C11ORF80 chromosome 11 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C1ORF105 chromosome 1 open reading frame 105
CCNJ cyclin J
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPB centromere protein B, 80kDa
CLCN2 chloride channel, voltage-sensitive 2
CLEC16A C-type lectin domain family 16, member A
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CPTP ceramide-1-phosphate transfer protein
CST6 cystatin E/M
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DCAF17 DDB1 and CUL4 associated factor 17
DGAT1 diacylglycerol O-acyltransferase 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELP3 elongator acetyltransferase complex subunit 3
ERCC4 excision repair cross-complementation group 4
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM102A family with sequence similarity 102, member A
FAR2 fatty acyl CoA reductase 2
FBXL15 F-box and leucine-rich repeat protein 15
FBXL6 F-box and leucine-rich repeat protein 6
FBXO31 F-box protein 31
FLJ22184
FURIN furin (paired basic amino acid cleaving enzyme)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HP1BP3 heterochromatin protein 1, binding protein 3
IRF6 interferon regulatory factor 6
ITPKB inositol-trisphosphate 3-kinase B
KLHL25 kelch-like family member 25
LAMA3 laminin, alpha 3
LZTR1 leucine-zipper-like transcription regulator 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCOLN1 mucolipin 1
MEFV Mediterranean fever
MTHFSD methenyltetrahydrofolate synthetase domain containing
NOD1 nucleotide-binding oligomerization domain containing 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PCDHA9 protocadherin alpha 9
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODXL2 podocalyxin-like 2
POLH polymerase (DNA directed), eta
PROCR protein C receptor, endothelial
PRR14L proline rich 14-like
PRR4 proline rich 4 (lacrimal)
PTK6 protein tyrosine kinase 6
PTPRU protein tyrosine phosphatase, receptor type, U
QSER1 glutamine and serine rich 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RBM15B RNA binding motif protein 15B
RIN2 Ras and Rab interactor 2
RLF rearranged L-myc fusion
RLN2 relaxin 2
RNF126P1 ring finger protein 126 pseudogene 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SHPK sedoheptulokinase
SLC22A14 solute carrier family 22, member 14
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SND1-IT1 SND1 intronic transcript 1
STARD3 StAR-related lipid transfer (START) domain containing 3
SUSD4 sushi domain containing 4
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC33 tetratricopeptide repeat domain 33
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
VEGFB vascular endothelial growth factor B
WDR62 WD repeat domain 62
ZBTB22 zinc finger and BTB domain containing 22
ZC3H12A zinc finger CCCH-type containing 12A
ZNF350 zinc finger protein 350
ZNF423 zinc finger protein 423
ZNF586 zinc finger protein 586
ZSCAN31 zinc finger and SCAN domain containing 31