drofenine-2714 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the drofenine-2714 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACVR1B activin A receptor, type IB
ADRB3 adrenoceptor beta 3
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AP1M2 adaptor-related protein complex 1, mu 2 subunit
APOL2 apolipoprotein L, 2
AR androgen receptor
ARID4B AT rich interactive domain 4B (RBP1-like)
BAIAP2 BAI1-associated protein 2
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BEST1 bestrophin 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1ORF68 chromosome 1 open reading frame 68
CACFD1 calcium channel flower domain containing 1
CCDC82 coiled-coil domain containing 82
CD27 CD27 molecule
CIZ1 CDKN1A interacting zinc finger protein 1
CLTA clathrin, light chain A
COPZ2 coatomer protein complex, subunit zeta 2
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CXCR1 chemokine (C-X-C motif) receptor 1
DAPK1 death-associated protein kinase 1
DCTN2 dynactin 2 (p50)
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DOK5 docking protein 5
DRD5 dopamine receptor D5
EFNA3 ephrin-A3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EML2 echinoderm microtubule associated protein like 2
FBXO21 F-box protein 21
FGF17 fibroblast growth factor 17
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GPR132 G protein-coupled receptor 132
GPRASP1 G protein-coupled receptor associated sorting protein 1
GPRC5D G protein-coupled receptor, class C, group 5, member D
HIPK3 homeodomain interacting protein kinase 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXA11 homeobox A11
HSPA2 heat shock 70kDa protein 2
IFI44 interferon-induced protein 44
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA0513 KIAA0513
KLF6 Kruppel-like factor 6
LEFTY1 left-right determination factor 1
LMNA lamin A/C
MC5R melanocortin 5 receptor
MFAP5 microfibrillar associated protein 5
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYH14 myosin, heavy chain 14, non-muscle
MYOM1 myomesin 1
NCKAP1 NCK-associated protein 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NELL2 NEL-like 2 (chicken)
NKX2-5 NK2 homeobox 5
NRF1 nuclear respiratory factor 1
OR6A2 olfactory receptor, family 6, subfamily A, member 2
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PAPPA2 pappalysin 2
PCDHA6 protocadherin alpha 6
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
POFUT2 protein O-fucosyltransferase 2
PRUNE prune exopolyphosphatase
PSEN2 presenilin 2
PTPRF protein tyrosine phosphatase, receptor type, F
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RENBP renin binding protein
RHOD ras homolog family member D
RORA RAR-related orphan receptor A
RUNDC3A RUN domain containing 3A
SCAMP5 secretory carrier membrane protein 5
SEC14L5 SEC14-like 5 (S. cerevisiae)
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC25A30 solute carrier family 25, member 30
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOX13 SRY (sex determining region Y)-box 13
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRRM2 serine/arginine repetitive matrix 2
SSX3 synovial sarcoma, X breakpoint 3
STAC SH3 and cysteine rich domain
SYNM synemin, intermediate filament protein
TMOD1 tropomodulin 1
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TPH1 tryptophan hydroxylase 1
TRIM62 tripartite motif containing 62
TYMP thymidine phosphorylase
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XDH xanthine dehydrogenase
ZHX3 zinc fingers and homeoboxes 3
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACPP acid phosphatase, prostate
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMDHD2 amidohydrolase domain containing 2
ANKRD36 ankyrin repeat domain 36
ANXA2P2 annexin A2 pseudogene 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BANK1 B-cell scaffold protein with ankyrin repeats 1
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF30 chromosome 11 open reading frame 30
C7ORF43 chromosome 7 open reading frame 43
C9ORF114 chromosome 9 open reading frame 114
CCDC85C coiled-coil domain containing 85C
CDK3 cyclin-dependent kinase 3
CEP97 centrosomal protein 97kDa
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CISH cytokine inducible SH2-containing protein
CLEC2D C-type lectin domain family 2, member D
CTSV cathepsin V
DDN dendrin
DENND5B DENN/MADD domain containing 5B
DNAL4 dynein, axonemal, light chain 4
DTX2 deltex 2, E3 ubiquitin ligase
DTX4 deltex 4, E3 ubiquitin ligase
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FAM102A family with sequence similarity 102, member A
FER fer (fps/fes related) tyrosine kinase
FOXD1 forkhead box D1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALK1 galactokinase 1
GCH1 GTP cyclohydrolase 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR75 G protein-coupled receptor 75
GRIP2 glutamate receptor interacting protein 2
GRPR gastrin-releasing peptide receptor
GSTZ1 glutathione S-transferase zeta 1
HDAC7 histone deacetylase 7
HIST1H2AM histone cluster 1, H2am
HIST1H2BI histone cluster 1, H2bi
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IDI2-AS1 IDI2 antisense RNA 1
IGSF6 immunoglobulin superfamily, member 6
IL4R interleukin 4 receptor
INO80D INO80 complex subunit D
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0319L KIAA0319-like
KLHL36 kelch-like family member 36
LPPR3 lipid phosphate phosphatase-related protein type 3
LTBP3 latent transforming growth factor beta binding protein 3
LYPLA2P1 lysophospholipase II pseudogene 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
NAG18 NAG18 mRNA
NBEA neurobeachin
NCS1 neuronal calcium sensor 1
NHEJ1 nonhomologous end-joining factor 1
NME8 NME/NM23 family member 8
NOL10 nucleolar protein 10
NT5DC3 5'-nucleotidase domain containing 3
NTSR1 neurotensin receptor 1 (high affinity)
OLAH oleoyl-ACP hydrolase
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OXCT2 3-oxoacid CoA transferase 2
PARP12 poly (ADP-ribose) polymerase family, member 12
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PKD2L2 polycystic kidney disease 2-like 2
PLA2G1B phospholipase A2, group IB (pancreas)
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
RAB3A RAB3A, member RAS oncogene family
RCAN3 RCAN family member 3
REC8 REC8 meiotic recombination protein
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
S1PR4 sphingosine-1-phosphate receptor 4
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SHARPIN SHANK-associated RH domain interactor
SPATA1 spermatogenesis associated 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAS2R10 taste receptor, type 2, member 10
TBL1Y transducin (beta)-like 1, Y-linked
TICAM1 toll-like receptor adaptor molecule 1
TMEM209 transmembrane protein 209
TOR4A torsin family 4, member A
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
USP6NL USP6 N-terminal like
VASH1 vasohibin 1
ZBTB25 zinc finger and BTB domain containing 25
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF250 zinc finger protein 250
ZNF747 zinc finger protein 747