dropropizine-5531 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the dropropizine-5531 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADCY2 adenylate cyclase 2 (brain)
ALOX12 arachidonate 12-lipoxygenase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APAF1 apoptotic peptidase activating factor 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARG1 arginase 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ATG10 autophagy related 10
BAX BCL2-associated X protein
BMP15 bone morphogenetic protein 15
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTD biotinidase
C11ORF30 chromosome 11 open reading frame 30
C2ORF68 chromosome 2 open reading frame 68
C3ORF18 chromosome 3 open reading frame 18
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CDC42 cell division cycle 42
CDK10 cyclin-dependent kinase 10
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CNN1 calponin 1, basic, smooth muscle
COL13A1 collagen, type XIII, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPA4 carboxypeptidase A4
CYLD cylindromatosis (turban tumor syndrome)
DCTN2 dynactin 2 (p50)
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DIXDC1 DIX domain containing 1
EDRF1 erythroid differentiation regulatory factor 1
ELOVL2 ELOVL fatty acid elongase 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EVA1B eva-1 homolog B (C. elegans)
FAM188A family with sequence similarity 188, member A
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
HIRA histone cell cycle regulator
HIST1H1B histone cluster 1, H1b
HIST1H1E histone cluster 1, H1e
HP1BP3 heterochromatin protein 1, binding protein 3
HSPG2 heparan sulfate proteoglycan 2
IFT38 intraflagellar transport 38
IL11 interleukin 11
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
INPP5K inositol polyphosphate-5-phosphatase K
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KLHL25 kelch-like family member 25
KRT17 keratin 17, type I
LAMA2 laminin, alpha 2
LIME1 Lck interacting transmembrane adaptor 1
LMNB1 lamin B1
LRP6 low density lipoprotein receptor-related protein 6
LRRC61 leucine rich repeat containing 61
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAX MYC associated factor X
MERTK MER proto-oncogene, tyrosine kinase
MFAP5 microfibrillar associated protein 5
MVK mevalonate kinase
NEURL1 neuralized E3 ubiquitin protein ligase 1
NMT1 N-myristoyltransferase 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OSMR oncostatin M receptor
PCDHB3 protocadherin beta 3
PHF7 PHD finger protein 7
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G5 phospholipase A2, group V
PLEKHO2 pleckstrin homology domain containing, family O member 2
POFUT1 protein O-fucosyltransferase 1
POU4F2 POU class 4 homeobox 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRB1 proline-rich protein BstNI subfamily 1
PRDM16 PR domain containing 16
PSG9 pregnancy specific beta-1-glycoprotein 9
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPL10L ribosomal protein L10-like
RPS9 ribosomal protein S9
SIDT2 SID1 transmembrane family, member 2
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNRK SNF related kinase
SPON1 spondin 1, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
STX1A syntaxin 1A (brain)
TBL1X transducin (beta)-like 1X-linked
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFEB transcription factor EB
TRAV8-3 T cell receptor alpha variable 8-3
TTLL3 tubulin tyrosine ligase-like family member 3
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VAV2 vav 2 guanine nucleotide exchange factor
VCAN versican
VIP vasoactive intestinal peptide
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACOT8 acyl-CoA thioesterase 8
ADAP2 ArfGAP with dual PH domains 2
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASCC2 activating signal cointegrator 1 complex subunit 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
ASRGL1 asparaginase like 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BATF basic leucine zipper transcription factor, ATF-like
BCL9 B-cell CLL/lymphoma 9
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C17ORF80 chromosome 17 open reading frame 80
C9ORF9 chromosome 9 open reading frame 9
CAPN5 calpain 5
CDC37 cell division cycle 37
CENPO centromere protein O
CERK ceramide kinase
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCN5 chloride channel, voltage-sensitive 5
CLEC4E C-type lectin domain family 4, member E
CLSPN claspin
DCAF13 DDB1 and CUL4 associated factor 13
ELSPBP1 epididymal sperm binding protein 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EXOC2 exocyst complex component 2
F2R coagulation factor II (thrombin) receptor
FBXL15 F-box and leucine-rich repeat protein 15
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GBP2 guanylate binding protein 2, interferon-inducible
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMEB1 glucocorticoid modulatory element binding protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HHLA3 HERV-H LTR-associating 3
HPSE heparanase
IL17RA interleukin 17 receptor A
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
JUNB jun B proto-oncogene
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KLF2 Kruppel-like factor 2
LAX1 lymphocyte transmembrane adaptor 1
LMBR1L limb development membrane protein 1-like
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYL5 myosin, light chain 5, regulatory
NES nestin
NKAIN1 Na+/K+ transporting ATPase interacting 1
NOL6 nucleolar protein 6 (RNA-associated)
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PCDHGB5 protocadherin gamma subfamily B, 5
PDGFRL platelet-derived growth factor receptor-like
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PITX2 paired-like homeodomain 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POM121 POM121 transmembrane nucleoporin
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRSS22 protease, serine, 22
RAB4B RAB4B, member RAS oncogene family
RANGRF RAN guanine nucleotide release factor
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF122 ring finger protein 122
RNF25 ring finger protein 25
ROM1 retinal outer segment membrane protein 1
RPGR retinitis pigmentosa GTPase regulator
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC12A9 solute carrier family 12, member 9
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TCTN1 tectonic family member 1
TGFBR3 transforming growth factor, beta receptor III
TMC7 transmembrane channel-like 7
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPST2 tyrosylprotein sulfotransferase 2
TRABD TraB domain containing
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN1 tetraspanin 1
TUBA3C tubulin, alpha 3c
VAV1 vav 1 guanine nucleotide exchange factor
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VWA1 von Willebrand factor A domain containing 1
WDR19 WD repeat domain 19
XK X-linked Kx blood group
ZFHX2 zinc finger homeobox 2
ZNF141 zinc finger protein 141
ZNF365 zinc finger protein 365
ZNF446 zinc finger protein 446
ZNF623 zinc finger protein 623
ZNF804A zinc finger protein 804A
ZNHIT2 zinc finger, HIT-type containing 2