droxidopa Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Description A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension (Chemical Entities of Biological Interest Ontology, CHEBI_31524)
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Genes

2 genes differentially expressed following the droxidopa small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 5.98024

decreased expression

Symbol Name Standardized Value
IKZF1 IKAROS family zinc finger 1 (Ikaros) -3.60003