drug-induced liver injury Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment. (Experimental Factor Ontology, EFO_0004228)
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Genes

20 genes associated with the disease drug-induced liver injury in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
C6ORF10 chromosome 6 open reading frame 10
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
GPX1 glutathione peroxidase 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
MCTP2 multiple C2 domains, transmembrane 2
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NR1I2 nuclear receptor subfamily 1, group I, member 2
SOD2 superoxide dismutase 2, mitochondrial
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
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