drugs Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

410 genes co-occuring with the biological term drugs in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABI2 abl-interactor 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ADD1 adducin 1 (alpha)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
AGER advanced glycosylation end product-specific receptor
AHR aryl hydrocarbon receptor
AKAP13 A kinase (PRKA) anchor protein 13
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALK anaplastic lymphoma receptor tyrosine kinase
ALPP alkaline phosphatase, placental
ANXA4 annexin A4
AOC1 amine oxidase, copper containing 1
AOX1 aldehyde oxidase 1
APAF1 apoptotic peptidase activating factor 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA5 apolipoprotein A-V
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARRB2 arrestin, beta 2
ASGR1 asialoglycoprotein receptor 1
ASPN asporin
ATG5 autophagy related 5
ATOX1 antioxidant 1 copper chaperone
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATRN attractin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAK1 BCL2-antagonist/killer 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BAX BCL2-associated X protein
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL6 B-cell CLL/lymphoma 6
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BIRC2 baculoviral IAP repeat containing 2
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRSK2 BR serine/threonine kinase 2
BSG basigin (Ok blood group)
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBFB core-binding factor, beta subunit
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDA cytidine deaminase
CDC42 cell division cycle 42
CDK16 cyclin-dependent kinase 16
CDK5 cyclin-dependent kinase 5
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CES1 carboxylesterase 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK1 checkpoint kinase 1
CHODL chondrolectin
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLDN2 claudin 2
CLEC1B C-type lectin domain family 1, member B
CLU clusterin
COMP cartilage oligomeric matrix protein
COMT catechol-O-methyltransferase
CRBN cereblon
CREBBP CREB binding protein
CRHR1 corticotropin releasing hormone receptor 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CTSH cathepsin H
CTSL cathepsin L
CTSS cathepsin S
CUL5 cullin 5
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXXC4 CXXC finger protein 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A cytochrome P450, family 3, subfamily A
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DIABLO diablo, IAP-binding mitochondrial protein
DRD2 dopamine receptor D2
E2F1 E2F transcription factor 1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
ENG endoglin
EP300 E1A binding protein p300
EP400 E1A binding protein p400
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ETV4 ets variant 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F5 coagulation factor V (proaccelerin, labile factor)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO6 F-box protein 6
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FFAR1 free fatty acid receptor 1
FGF13 fibroblast growth factor 13
FMO1 flavin containing monooxygenase 1
FMR1 fragile X mental retardation 1
FXN frataxin
FXYD1 FXYD domain containing ion transport regulator 1
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GCLC glutamate-cysteine ligase, catalytic subunit
GHRL ghrelin/obestatin prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GLP1R glucagon-like peptide 1 receptor
GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2, pseudogene
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRM4 glutamate receptor, metabotropic 4
GSK3B glycogen synthase kinase 3 beta
H2AFX H2A histone family, member X
HBA1 hemoglobin, alpha 1
HDAC1 histone deacetylase 1
HDAC6 histone deacetylase 6
HEXIM1 hexamethylene bis-acetamide inducible 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMBS hydroxymethylbilane synthase
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HPSE2 heparanase 2 (inactive)
HRH1 histamine receptor H1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HVCN1 hydrogen voltage gated channel 1
ICAM1 intercellular adhesion molecule 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL11 interleukin 11
IL12RB1 interleukin 12 receptor, beta 1
IL17A interleukin 17A
IL2 interleukin 2
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL36RN interleukin 36 receptor antagonist
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
IRS1 insulin receptor substrate 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
JAK2 Janus kinase 2
KAT5 K(lysine) acetyltransferase 5
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNT1 potassium channel, sodium activated subfamily T, member 1
KDM1A lysine (K)-specific demethylase 1A
KDR kinase insert domain receptor
KL klotho
LAMA5 laminin, alpha 5
LAT2 linker for activation of T cells family, member 2
LEP leptin
LEPR leptin receptor
LIMK2 LIM domain kinase 2
LPA lipoprotein, Lp(a)
LRPPRC leucine-rich pentatricopeptide repeat containing
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAOA monoamine oxidase A
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK1 mitogen-activated protein kinase 1
MAPK12 mitogen-activated protein kinase 12
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR155HG MIR155 host gene
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSH3 mutS homolog 3
MSLN mesothelin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC4 mucin 4, cell surface associated
MVP major vault protein
MYH9 myosin, heavy chain 9, non-muscle
MYOD1 myogenic differentiation 1
NAF1 nuclear assembly factor 1 ribonucleoprotein
NAMPT nicotinamide phosphoribosyltransferase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCAM1 neural cell adhesion molecule 1
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NMU neuromedin U
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOX4 NADPH oxidase 4
NPC1 Niemann-Pick disease, type C1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPRM1 opioid receptor, mu 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PANX1 pannexin 1
PARP1 poly (ADP-ribose) polymerase 1
PARVA parvin, alpha
PCDH19 protocadherin 19
PDZD4 PDZ domain containing 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
POU2F2 POU class 2 homeobox 2
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRDX5 peroxiredoxin 5
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKD1 protein kinase D1
PRL prolactin
PRNP prion protein
PROM1 prominin 1
PSEN1 presenilin 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTEN phosphatase and tensin homolog
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK6 protein tyrosine kinase 6
PTK7 protein tyrosine kinase 7 (inactive)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTX3 pentraxin 3, long
RAB27B RAB27B, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALBP1 ralA binding protein 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOU ras homolog family member U
RNASEH1 ribonuclease H1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RYR2 ryanodine receptor 2 (cardiac)
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SCN3A sodium channel, voltage gated, type III alpha subunit
SCN3B sodium channel, voltage gated, type III beta subunit
SELE selectin E
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A6 solute carrier family 16, member 6
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SMN2 survival of motor neuron 2, centromeric
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX2 sorting nexin 2
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
SREBF1 sterol regulatory element binding transcription factor 1
SRXN1 sulfiredoxin 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STMN1 stathmin 1
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TDP1 tyrosyl-DNA phosphodiesterase 1
TERT telomerase reverse transcriptase
THEMIS2 thymocyte selection associated family member 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP63 tumor protein p63
TPMT thiopurine S-methyltransferase
TPP1 tripeptidyl peptidase I
TRADD TNFRSF1A-associated via death domain
TRIM32 tripartite motif containing 32
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSHB thyroid stimulating hormone, beta
TSHR thyroid stimulating hormone receptor
TSPO translocator protein (18kDa)
TUBB1 tubulin, beta 1 class VI
TUBB3 tubulin, beta 3 class III
TYMP thymidine phosphorylase
UBE2B ubiquitin-conjugating enzyme E2B
UBE2I ubiquitin-conjugating enzyme E2I
UGT1A UDP glucuronosyltransferase 1 family, polypeptide A complex locus
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
ULBP1 UL16 binding protein 1
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
USP18 ubiquitin specific peptidase 18
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTS2 urotensin 2
VEGFA vascular endothelial growth factor A
VIM vimentin
VKORC1 vitamin K epoxide reductase complex, subunit 1
WLS wntless Wnt ligand secretion mediator
WNK1 WNK lysine deficient protein kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
WNT6 wingless-type MMTV integration site family, member 6
WRN Werner syndrome, RecQ helicase-like
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YBX1 Y box binding protein 1
YY1 YY1 transcription factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa