e2f1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description E2F transcription factor 1|The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1869)
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Genes

234 genes co-occuring with the biological term e2f1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AHR aryl hydrocarbon receptor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
APAF1 apoptotic peptidase activating factor 1
API5 apoptosis inhibitor 5
AR androgen receptor
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARRB1 arrestin, beta 1
ATAD2 ATPase family, AAA domain containing 2
ATM ATM serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
AXIN2 axin 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIN1 bridging integrator 1
BIRC2 baculoviral IAP repeat containing 2
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRD2 bromodomain containing 2
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTG3 BTG family, member 3
CARM1 coactivator-associated arginine methyltransferase 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNE1 cyclin E1
CCNE2 cyclin E2
CD2AP CD2-associated protein
CDC20 cell division cycle 20
CDCA7 cell division cycle associated 7
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK8 cyclin-dependent kinase 8
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B-AS1 CDKN2B antisense RNA 1
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CLSPN claspin
COPS2 COP9 signalosome subunit 2
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CSNK1A1 casein kinase 1, alpha 1
CTBP2 C-terminal binding protein 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTNND2 catenin (cadherin-associated protein), delta 2
CTSV cathepsin V
CUX1 cut-like homeobox 1
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK2 death-associated protein kinase 2
DBF4 DBF4 zinc finger
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F6 E2F transcription factor 6
E2F7 E2F transcription factor 7
E2F8 E2F transcription factor 8
EAPP E2F-associated phosphoprotein
ECT2 epithelial cell transforming 2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EI24 etoposide induced 2.4
ELL elongation factor RNA polymerase II
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EP300 E1A binding protein p300
ERCC1 excision repair cross-complementation group 1
ESR1 estrogen receptor 1
ETV4 ets variant 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FHIT fragile histidine triad
FOXM1 forkhead box M1
FOXO3 forkhead box O3
FZD1 frizzled class receptor 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GRAMD4 GRAM domain containing 4
HCFC1 host cell factor C1
HDAC1 histone deacetylase 1
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HES6 hes family bHLH transcription factor 6
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IL1B interleukin 1, beta
IL6 interleukin 6
IRF3 interferon regulatory factor 3
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KIAA1524 KIAA1524
KIF23 kinesin family member 23
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KLF6 Kruppel-like factor 6
KMT2A lysine (K)-specific methyltransferase 2A
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LIMD1 LIM domains containing 1
LOXL1 lysyl oxidase-like 1
MAGEA11 melanoma antigen family A11
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MCPH1 microcephalin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MECOM MDS1 and EVI1 complex locus
MIR106A microRNA 106a
MIR106B microRNA 106b
MIR149 microRNA 149
MIR17 microRNA 17
MIR17HG miR-17-92 cluster host gene
MIR202 microRNA 202
MIR205 microRNA 205
MIR20A microRNA 20a
MIR223 microRNA 223
MIR25 microRNA 25
MIR29A microRNA 29a
MIR320A microRNA 320a
MIR331 microRNA 331
MIR34A microRNA 34a
MIR509-3 microRNA 509-3
MIR93 microRNA 93
MKI67 marker of proliferation Ki-67
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP9 matrix metallopeptidase 9
MRPS18B mitochondrial ribosomal protein S18B
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NELL2 NEL-like 2 (chicken)
NFYA nuclear transcription factor Y, alpha
NGF nerve growth factor (beta polypeptide)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRIP1 nuclear receptor interacting protein 1
NUSAP1 nucleolar and spindle associated protein 1
ORC1 origin recognition complex, subunit 1
PAX8 paired box 8
PBK PDZ binding kinase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGR progesterone receptor
PHB prohibitin
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLK1 polo-like kinase 1
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PTPRO protein tyrosine phosphatase, receptor type, O
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
QKI QKI, KH domain containing, RNA binding
RACGAP1 Rac GTPase activating protein 1
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBM38 RNA binding motif protein 38
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOBTB2 Rho-related BTB domain containing 2
RNF2 ring finger protein 2
RORA RAR-related orphan receptor A
RPTOR regulatory associated protein of MTOR, complex 1
RRP1B ribosomal RNA processing 1B
SCG3 secretogranin III
SENP8 SUMO/sentrin specific peptidase family member 8
SIAH1 siah E3 ubiquitin protein ligase 1
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD7 SMAD family member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SP1 Sp1 transcription factor
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRSF2 serine/arginine-rich splicing factor 2
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFDP1 transcription factor Dp-1
TFDP3 transcription factor Dp family, member 3
TGFB1 transforming growth factor, beta 1
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP73 tumor protein p73
TRIB2 tribbles pseudokinase 2
TRIM16 tripartite motif containing 16
TRIM28 tripartite motif containing 28
UBE2C ubiquitin-conjugating enzyme E2C
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UNC5D unc-5 homolog D (C. elegans)
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
WWOX WW domain containing oxidoreductase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YARS tyrosyl-tRNA synthetase
YY1 YY1 transcription factor
ZFP36 ZFP36 ring finger protein
ZNF346 zinc finger protein 346
ZNF512B zinc finger protein 512B