e2f2_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS4094
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Genes

288 genes differentially expressed following the e2f2_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.210758
PINK1 PTEN induced putative kinase 1 0.210758
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) 0.210702
CAPZB capping protein (actin filament) muscle Z-line, beta 0.210394
CLIC4 chloride intracellular channel 4 0.210012
PDIK1L PDLIM1 interacting kinase 1 like 0.209229
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 0.204027
FUCA1 fucosidase, alpha-L- 1, tissue 0.201171
SOCS4 suppressor of cytokine signaling 4 0.19922
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.194917
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 0.191602
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.186099
TRAT1 T cell receptor associated transmembrane adaptor 1 0.183993
COQ10A coenzyme Q10 homolog A (S. cerevisiae) 0.182744
SPNS1 spinster homolog 1 (Drosophila) 0.180826
UCK2 uridine-cytidine kinase 2 0.175063
CNTN4 contactin 4 0.174986
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.17434
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 0.173803
OVOL1 ovo-like zinc finger 1 0.169412
ZNF706 zinc finger protein 706 0.166982
ACBD6 acyl-CoA binding domain containing 6 0.161417
ADAM28 ADAM metallopeptidase domain 28 0.156361
GRHL2 grainyhead-like 2 (Drosophila) 0.152947
SLC35A5 solute carrier family 35, member A5 0.151499
CUTC cutC copper transporter 0.143115
RNF2 ring finger protein 2 0.13692
GRK6 G protein-coupled receptor kinase 6 0.136747
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 0.129253
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 0.126765
GDI2 GDP dissociation inhibitor 2 0.121628
CNTNAP2 contactin associated protein-like 2 0.118597
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.110968
EYA4 EYA transcriptional coactivator and phosphatase 4 0.108331
INTS12 integrator complex subunit 12 0.108254
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 0.094135
GFRA2 GDNF family receptor alpha 2 0.093212
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 0.093182
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.089254
TRIM16 tripartite motif containing 16 0.088252
KRTAP1-5 keratin associated protein 1-5 0.08621
THOC6 THO complex 6 0.086136
SYT7 synaptotagmin VII 0.085229
SGOL1 shugoshin-like 1 (S. pombe) 0.084981
POLR1D polymerase (RNA) I polypeptide D, 16kDa 0.07444
TUBB tubulin, beta class I 0.066065
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.059456
CLDN3 claudin 3 0.058545
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 0.058018
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.055483
SLC25A30 solute carrier family 25, member 30 0.052446
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 0.052211
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 0.051392
IL12A interleukin 12A 0.048514
PLK1 polo-like kinase 1 0.048341
ARID5B AT rich interactive domain 5B (MRF1-like) 0.046555
NCAM2 neural cell adhesion molecule 2 0.042732
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.042647
SPP2 secreted phosphoprotein 2, 24kDa 0.041041
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase 0.04045
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.039888
NTNG1 netrin G1 0.031894
ILF3 interleukin enhancer binding factor 3, 90kDa 0.028474
KLF3 Kruppel-like factor 3 (basic) 0.025419
KLF13 Kruppel-like factor 13 0.020977
NMUR1 neuromedin U receptor 1 0.019021
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.015361
HMGN1 high mobility group nucleosome binding domain 1 0.014458
FAF1 Fas (TNFRSF6) associated factor 1 0.013406
CCNB1 cyclin B1 0.013356
FAM50B family with sequence similarity 50, member B 0.012807
METAP2 methionyl aminopeptidase 2 0.011891
MUTYH mutY homolog 0.00209
TRIM21 tripartite motif containing 21 0.00188
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 8.04E-4
TBRG1 transforming growth factor beta regulator 1 5.71E-4

decreased expression

Symbol Name Standardized Value
SRRM1 serine/arginine repetitive matrix 1 -1.25627
FAM76A family with sequence similarity 76, member A -1.24669
EMC3 ER membrane protein complex subunit 3 -1.2429
WNK1 WNK lysine deficient protein kinase 1 -1.24241
TMEM168 transmembrane protein 168 -1.23989
SDCCAG3 serologically defined colon cancer antigen 3 -1.23915
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -1.23882
KIAA1147 KIAA1147 -1.23448
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 -1.20417
CNOT4 CCR4-NOT transcription complex, subunit 4 -1.19981
MTPN myotrophin -1.19821
SEPN1 selenoprotein N, 1 -1.19789
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 -1.19194
ARHGAP35 Rho GTPase activating protein 35 -1.16852
LHX2 LIM homeobox 2 -1.16153
TPRA1 transmembrane protein, adipocyte asscociated 1 -1.15113
LIMK1 LIM domain kinase 1 -1.12779
MOB1A MOB kinase activator 1A -1.11466
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -1.11142
ERC1 ELKS/RAB6-interacting/CAST family member 1 -1.11062
IQSEC1 IQ motif and Sec7 domain 1 -1.1088
TADA3 transcriptional adaptor 3 -1.09813
CALU calumenin -1.07488
GOLT1B golgi transport 1B -1.05807
TLE2 transducin-like enhancer of split 2 -1.05333
PADI4 peptidyl arginine deiminase, type IV -1.05221
AAK1 AP2 associated kinase 1 -1.04824
ZFHX3 zinc finger homeobox 3 -1.02132
GON4L gon-4-like (C. elegans) -1.02085
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 -1.01533
PON2 paraoxonase 2 -1.01399
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -1.00902
ACER2 alkaline ceramidase 2 -0.994115
NCDN neurochondrin -0.990691
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 -0.989278
MTAP methylthioadenosine phosphorylase -0.972775
MDFIC MyoD family inhibitor domain containing -0.966196
CAPN15 calpain 15 -0.939167
EVPL envoplakin -0.937171
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 -0.935423
MLEC malectin -0.929096
LUZP1 leucine zipper protein 1 -0.926598
GGCT gamma-glutamylcyclotransferase -0.921616
RAD52 RAD52 homolog (S. cerevisiae) -0.920321
TYK2 tyrosine kinase 2 -0.912444
MXD4 MAX dimerization protein 4 -0.90936
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 -0.88753
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.882017
DCTN1 dynactin 1 -0.873877
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -0.870172
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) -0.866591
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.858878
CELF4 CUGBP, Elav-like family member 4 -0.855363
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.854091
ANXA4 annexin A4 -0.840927
PRPF4B pre-mRNA processing factor 4B -0.83472
POFUT2 protein O-fucosyltransferase 2 -0.826858
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 -0.818375
NCOR2 nuclear receptor corepressor 2 -0.814032
SUMF1 sulfatase modifying factor 1 -0.813689
FAM193B family with sequence similarity 193, member B -0.804447
SEC16A SEC16 homolog A (S. cerevisiae) -0.79414
MED22 mediator complex subunit 22 -0.793951
HDAC6 histone deacetylase 6 -0.79
PAXBP1 PAX3 and PAX7 binding protein 1 -0.788551
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.785991
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase -0.780261
CCDC64 coiled-coil domain containing 64 -0.776649
CAPG capping protein (actin filament), gelsolin-like -0.775512
GGCX gamma-glutamyl carboxylase -0.772521
GPR85 G protein-coupled receptor 85 -0.766105
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -0.757715
POMK protein-O-mannose kinase -0.754533
METAP1D methionyl aminopeptidase type 1D (mitochondrial) -0.743165
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -0.74177
ZGPAT zinc finger, CCCH-type with G patch domain -0.739706
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.739706
IRF3 interferon regulatory factor 3 -0.73761
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.735774
PNPLA6 patatin-like phospholipase domain containing 6 -0.72908
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase -0.718915
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -0.712758
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) -0.712088
KLRC1 killer cell lectin-like receptor subfamily C, member 1 -0.711891
HIP1 huntingtin interacting protein 1 -0.708368
RNF103 ring finger protein 103 -0.706811
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.706384
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.696081
FGFR1OP2 FGFR1 oncogene partner 2 -0.69142
BRWD1 bromodomain and WD repeat domain containing 1 -0.686595
DMTF1 cyclin D binding myb-like transcription factor 1 -0.684863
GCC1 GRIP and coiled-coil domain containing 1 -0.681647
INTS6 integrator complex subunit 6 -0.673292
RAB7A RAB7A, member RAS oncogene family -0.661095
IL17RA interleukin 17 receptor A -0.654022
TOP1 topoisomerase (DNA) I -0.650979
PHF21A PHD finger protein 21A -0.648916
NOTCH4 notch 4 -0.647309
LRRC20 leucine rich repeat containing 20 -0.641724
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -0.635391
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 -0.628478
KRTAP3-1 keratin associated protein 3-1 -0.625998
CDC37L1 cell division cycle 37-like 1 -0.625178
MFN1 mitofusin 1 -0.62151
REV1 REV1, polymerase (DNA directed) -0.619486
BANP BTG3 associated nuclear protein -0.615415
DFNA5 deafness, autosomal dominant 5 -0.614821
NFIC nuclear factor I/C (CCAAT-binding transcription factor) -0.608531
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -0.605238
PTPRN protein tyrosine phosphatase, receptor type, N -0.603955
FBXO25 F-box protein 25 -0.603634
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 -0.603127
RFX5 regulatory factor X, 5 (influences HLA class II expression) -0.5912
PFDN5 prefoldin subunit 5 -0.58955
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -0.586168
CHD4 chromodomain helicase DNA binding protein 4 -0.580215
GMCL1 germ cell-less, spermatogenesis associated 1 -0.580098
TMEM30A transmembrane protein 30A -0.577167
RPIA ribose 5-phosphate isomerase A -0.575311
RAB40C RAB40C, member RAS oncogene family -0.572952
TOR4A torsin family 4, member A -0.567447
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.567056
TM2D2 TM2 domain containing 2 -0.562604
CXXC5 CXXC finger protein 5 -0.561999
MRPS9 mitochondrial ribosomal protein S9 -0.558117
EXOC4 exocyst complex component 4 -0.552706
WASL Wiskott-Aldrich syndrome-like -0.548345
FAM73B family with sequence similarity 73, member B -0.546214
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -0.545751
CREBBP CREB binding protein -0.538398
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -0.537552
FBLN2 fibulin 2 -0.53502
MDFI MyoD family inhibitor -0.529242
C12ORF57 chromosome 12 open reading frame 57 -0.529242
REEP3 receptor accessory protein 3 -0.528051
NRF1 nuclear respiratory factor 1 -0.518763
MBD6 methyl-CpG binding domain protein 6 -0.512394
GDI1 GDP dissociation inhibitor 1 -0.510855
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -0.508542
TULP4 tubby like protein 4 -0.507164
NCKIPSD NCK interacting protein with SH3 domain -0.506865
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.505322
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.502287
ABHD8 abhydrolase domain containing 8 -0.499171
CAPRIN2 caprin family member 2 -0.487879
SDC3 syndecan 3 -0.48236
MBD4 methyl-CpG binding domain protein 4 -0.481918
NRK Nik related kinase -0.480856
RHOBTB2 Rho-related BTB domain containing 2 -0.480016
C9ORF78 chromosome 9 open reading frame 78 -0.474114
SLC35E1 solute carrier family 35, member E1 -0.473559
AKAP8L A kinase (PRKA) anchor protein 8-like -0.472833
STIM1 stromal interaction molecule 1 -0.472765
NELL2 NEL-like 2 (chicken) -0.470695
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -0.469144
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -0.467369
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -0.466768
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.465462
RPL35 ribosomal protein L35 -0.464355
IFNG interferon, gamma -0.46416
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.46192
ZNF746 zinc finger protein 746 -0.45729
SON SON DNA binding protein -0.455686
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.451091
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) -0.449049
RCAN1 regulator of calcineurin 1 -0.44877
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -0.44777
AK1 adenylate kinase 1 -0.447077
REM1 RAS (RAD and GEM)-like GTP-binding 1 -0.444165
PIGF phosphatidylinositol glycan anchor biosynthesis, class F -0.442693
CHD7 chromodomain helicase DNA binding protein 7 -0.442278
ARF5 ADP-ribosylation factor 5 -0.441709
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.438424
TOR1B torsin family 1, member B (torsin B) -0.436574
EI24 etoposide induced 2.4 -0.435489
ATP9A ATPase, class II, type 9A -0.435179
GRAMD1A GRAM domain containing 1A -0.431683
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.429518
LMBR1 limb development membrane protein 1 -0.428872
ATXN2 ataxin 2 -0.428528
TMEM150A transmembrane protein 150A -0.427197
GJA4 gap junction protein, alpha 4, 37kDa -0.426596
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -0.065307
OCLN occludin -0.065272
INSL6 insulin-like 6 -0.062301
PNPLA2 patatin-like phospholipase domain containing 2 -0.059006
MED1 mediator complex subunit 1 -0.057112
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.052187
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.052012
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -0.051269
STIL SCL/TAL1 interrupting locus -0.051269
EIF3C eukaryotic translation initiation factor 3, subunit C -0.049882
GTPBP1 GTP binding protein 1 -0.047965
CMTR1 cap methyltransferase 1 -0.043269
KPNA3 karyopherin alpha 3 (importin alpha 4) -0.039952
FZD6 frizzled class receptor 6 -0.039867
MASTL microtubule associated serine/threonine kinase-like -0.035536
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.034336
CD164 CD164 molecule, sialomucin -0.03277
DCC DCC netrin 1 receptor -0.03052
USP9Y ubiquitin specific peptidase 9, Y-linked -0.027965
DAZAP2 DAZ associated protein 2 -0.026097
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -0.024481
KRTAP6-1 keratin associated protein 6-1 -0.023862
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -0.023795
ENY2 enhancer of yellow 2 homolog (Drosophila) -0.018003
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -0.012722
ERCC4 excision repair cross-complementation group 4 -0.009819
RUNX2 runt-related transcription factor 2 -0.007224
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.005453
DCAF13 DDB1 and CUL4 associated factor 13 -0.003051
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 -0.00189
Funding