early endosome Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. (Gene Ontology, GO_0005769)
External Link http://amigo.geneontology.org/amigo/term/GO:0005769
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Genes

321 proteins localized to the early endosome cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADRB1 adrenoceptor beta 1
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD13B ankyrin repeat domain 13B
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANXA1 annexin A1
AOC3 amine oxidase, copper containing 3
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
AP1M1 adaptor-related protein complex 1, mu 1 subunit
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AP1S3 adaptor-related protein complex 1, sigma 3 subunit
AP3B1 adaptor-related protein complex 3, beta 1 subunit
AP3B2 adaptor-related protein complex 3, beta 2 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AP3M1 adaptor-related protein complex 3, mu 1 subunit
AP3M2 adaptor-related protein complex 3, mu 2 subunit
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARL8B ADP-ribosylation factor-like 8B
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP11B ATPase, class VI, type 11B
ATP13A3 ATPase type 13A3
ATP13A4 ATPase type 13A4
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATP9A ATPase, class II, type 9A
B2M beta-2-microglobulin
BACE1 beta-site APP-cleaving enzyme 1
BAIAP3 BAI1-associated protein 3
BLTP3B bridge-like lipid transfer protein family member 3B
BOK BCL2-related ovarian killer
C1D C1D nuclear receptor corepressor
CAV1 caveolin 1, caveolae protein, 22kDa
CD207 CD207 molecule, langerin
CD22 CD22 molecule
CD274 CD274 molecule
CD4 CD4 molecule
CD8B CD8b molecule
CDC50A cell division cycle 50 P4-ATPase accessory subunit A
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHMP1A charged multivesicular body protein 1A
CLCN3 chloride channel, voltage-sensitive 3
CLCN4 chloride channel, voltage-sensitive 4
CLCN5 chloride channel, voltage-sensitive 5
CLIP3 CAP-GLY domain containing linker protein 3
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLTCL1 clathrin, heavy chain-like 1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNTNAP2 contactin associated protein-like 2
COMMD1 copper metabolism (Murr1) domain containing 1
CRYZL1 crystallin, zeta (quinone reductase)-like 1
CTNS cystinosin, lysosomal cystine transporter
CXCR4 chemokine (C-X-C motif) receptor 4
DAGLA diacylglycerol lipase, alpha
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNER delta/notch-like EGF repeat containing
DOP1B DOP1 leucine zipper like protein B
DTX3L deltex 3 like, E3 ubiquitin ligase
DYSF dysferlin
ECE1 endothelin converting enzyme 1
ECPAS Ecm29 proteasome adaptor and scaffold
EEA1 early endosome antigen 1
EGFR epidermal growth factor receptor
EHD1 EH-domain containing 1
EHD2 EH-domain containing 2
EHD3 EH-domain containing 3
EHD4 EH-domain containing 4
ENTR1 endosome associated trafficking regulator 1
ENTREP1 endosomal transmembrane epsin interactor 1
EPHA3 EPH receptor A3
EPHA4 EPH receptor A4
EPHB1 EPH receptor B1
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F8A1 coagulation factor VIII-associated 1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCMR Fc fragment of IgM receptor
FERRY3 FERRY endosomal RAB5 effector complex subunit 3
FIG4 FIG4 phosphoinositide 5-phosphatase
FLOT1 flotillin 1
FZD5 frizzled class receptor 5
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GPER1 G protein-coupled estrogen receptor 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
HFE hemochromatosis
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HPS3 Hermansky-Pudlak syndrome 3
HPS5 Hermansky-Pudlak syndrome 5
HPS6 Hermansky-Pudlak syndrome 6
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HYAL3 hyaluronoglucosaminidase 3
IFITM3 interferon induced transmembrane protein 3
IGF2R insulin-like growth factor 2 receptor
INPP5F inositol polyphosphate-5-phosphatase F
ITCH itchy E3 ubiquitin protein ligase
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDR kinase insert domain receptor
KIAA0319 KIAA0319
KIF16B kinesin family member 16B
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KREMEN2 kringle containing transmembrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LIPG lipase, endothelial
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMTK2 lemur tyrosine kinase 2
LNPEP leucyl/cystinyl aminopeptidase
LRP6 low density lipoprotein receptor-related protein 6
LTF lactotransferrin
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPKAP1 mitogen-activated protein kinase associated protein 1
MARCHF1 membrane associated ring-CH-type finger 1
MARCHF8 membrane associated ring-CH-type finger 8
MELTF melanotransferrin
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MICALL1 MICAL-like 1
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MMGT1 membrane magnesium transporter 1
MMP12 matrix metallopeptidase 12
MON2 MON2 homolog (S. cerevisiae)
MTMR4 myotubularin related protein 4
MVB12B multivesicular body subunit 12B
MYO1B myosin IB
MYO5A myosin VA (heavy chain 12, myoxin)
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D
NEU3 sialidase 3 (membrane sialidase)
NEURL1B neuralized E3 ubiquitin protein ligase 1B
NEURL3 neuralized E3 ubiquitin protein ligase 3
NF2 neurofibromin 2 (merlin)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOX1 NADPH oxidase 1
NRP1 neuropilin 1
NSG1 neuron specific gene family member 1
NSG2 neuronal vesicle trafficking associated 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OCRL oculocerebrorenal syndrome of Lowe
OR51E2 olfactory receptor, family 51, subfamily E, member 2
OSBPL6 oxysterol binding protein-like 6
PARM1 prostate androgen-regulated mucin-like protein 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PDLIM4 PDZ and LIM domain 4
PHB1 prohibitin 1
PHETA1 PH domain containing endocytic trafficking adaptor 1
PHETA2 PH domain containing endocytic trafficking adaptor 2
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PI4K2B phosphatidylinositol 4-kinase type 2 beta
PICALM phosphatidylinositol binding clathrin assembly protein
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLA2G4E phospholipase A2, group IVE
PLD3 phospholipase D family, member 3
PLD4 phospholipase D family, member 4
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLPP2 phospholipid phosphatase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PNKD paroxysmal nonkinesigenic dyskinesia
PPP1R21 protein phosphatase 1, regulatory subunit 21
PRDX3 peroxiredoxin 3
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN23 protein tyrosine phosphatase, non-receptor type 23
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB14 RAB14, member RAS oncogene family
RAB17 RAB17, member RAS oncogene family
RAB20 RAB20, member RAS oncogene family
RAB21 RAB21, member RAS oncogene family
RAB22A RAB22A, member RAS oncogene family
RAB29 RAB29, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RAB4B RAB4B, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RABGAP1L RAB GTPase activating protein 1-like
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RAP1A RAP1A, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RBSN rabenosyn, RAB effector
RCSD1 RCSD domain containing 1
RIN3 Ras and Rab interactor 3
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
RUBCN rubicon autophagy regulator
RUFY1 RUN and FYVE domain containing 1
RUSC1 RUN and SH3 domain containing 1
SH3GL2 SH3-domain GRB2-like 2
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13
SLC30A10 solute carrier family 30, member 10
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC35D3 solute carrier family 35, member D3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
SNX1 sorting nexin 1
SNX12 sorting nexin 12
SNX13 sorting nexin 13
SNX16 sorting nexin 16
SNX17 sorting nexin 17
SNX20 sorting nexin 20
SNX21 sorting nexin family member 21
SNX27 sorting nexin family member 27
SNX3 sorting nexin 3
SNX30 sorting nexin family member 30
SNX31 sorting nexin 31
SNX4 sorting nexin 4
SNX6 sorting nexin 6
SNX7 sorting nexin 7
SNX8 sorting nexin 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SORT1 sortilin 1
SPHK1 sphingosine kinase 1
STEAP2 STEAP family member 2, metalloreductase
STX6 syntaxin 6
STX7 syntaxin 7
STX8 syntaxin 8
SYNDIG1 synapse differentiation inducing 1
TBC1D16 TBC1 domain family, member 16
TBC1D2B TBC1 domain family, member 2B
TBC1D3I TBC1 domain family member 3I
TF transferrin
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TICAM1 toll-like receptor adaptor molecule 1
TLR3 toll-like receptor 3
TLR9 toll-like receptor 9
TM9SF4 transmembrane 9 superfamily protein member 4
TMED7-TICAM2 TMED7-TICAM2 readthrough
TMEM108 transmembrane protein 108
TMEM127 transmembrane protein 127
TMEM163 transmembrane protein 163
TMEM184A transmembrane protein 184A
TMEM230 transmembrane protein 230
TMEM63A transmembrane protein 63A
TMEM63B transmembrane protein 63B
TMEM9B TMEM9 domain family, member B
TOM1 target of myb1 (chicken)
TPCN1 two pore segment channel 1
TRAK1 trafficking protein, kinesin binding 1
TSG101 tumor susceptibility 101
UBXN6 UBX domain protein 6
USP32 ubiquitin specific peptidase 32
USP8 ubiquitin specific peptidase 8
UVRAG UV radiation resistance associated
VAC14 Vac14 homolog (S. cerevisiae)
VAMP8 vesicle-associated membrane protein 8
VCAM1 vascular cell adhesion molecule 1
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VPS26B vacuolar protein sorting 26 homolog B (S. pombe)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
VTI1B vesicle transport through interaction with t-SNAREs 1B
WASHC1 WASH complex subunit 1
WASHC2A WASH complex subunit 2A
WASHC2C WASH complex subunit 2C
WASHC3 WASH complex subunit 3
WASHC4 WASH complex subunit 4
WASHC5 WASH complex subunit 5
WDFY1 WD repeat and FYVE domain containing 1
WDFY2 WD repeat and FYVE domain containing 2
WDR81 WD repeat domain 81
WDR91 WD repeat domain 91
WIPF3 WAS/WASL interacting protein family, member 3
WLS wntless Wnt ligand secretion mediator
WNT3A wingless-type MMTV integration site family, member 3A
ZFYVE16 zinc finger, FYVE domain containing 16
ZFYVE26 zinc finger, FYVE domain containing 26
ZFYVE28 zinc finger, FYVE domain containing 28
ZFYVE9 zinc finger, FYVE domain containing 9