ebselen-5778 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the ebselen-5778 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
AIM1L absent in melanoma 1-like
AKR1C2 aldo-keto reductase family 1, member C2
ANXA10 annexin A10
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
AQP7 aquaporin 7
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
B9D1 B9 protein domain 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C11ORF21 chromosome 11 open reading frame 21
C16ORF70 chromosome 16 open reading frame 70
C9ORF9 chromosome 9 open reading frame 9
CAMKMT calmodulin-lysine N-methyltransferase
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFAP69 cilia and flagella associated protein 69
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCN7 chloride channel, voltage-sensitive 7
CNGB3 cyclic nucleotide gated channel beta 3
COL9A2 collagen, type IX, alpha 2
CPNE7 copine VII
CRYAB crystallin, alpha B
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CST4 cystatin S
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DMPK dystrophia myotonica-protein kinase
DOK2 docking protein 2, 56kDa
EGR1 early growth response 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EML2 echinoderm microtubule associated protein like 2
ENO3 enolase 3 (beta, muscle)
EREG epiregulin
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
GGT1 gamma-glutamyltransferase 1
GPR17 G protein-coupled receptor 17
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM1 glutamate receptor, metabotropic 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IL36A interleukin 36, alpha
IRF4 interferon regulatory factor 4
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCTD17 potassium channel tetramerization domain containing 17
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KRT34 keratin 34, type I
LBP lipopolysaccharide binding protein
LDAH lipid droplet associated hydrolase
LY9 lymphocyte antigen 9
MBD2 methyl-CpG binding domain protein 2
MINK1 misshapen-like kinase 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MRPL41 mitochondrial ribosomal protein L41
MTRF1L mitochondrial translational release factor 1-like
NOTCH4 notch 4
NR1I3 nuclear receptor subfamily 1, group I, member 3
NRP2 neuropilin 2
PARP3 poly (ADP-ribose) polymerase family, member 3
PDE4D phosphodiesterase 4D, cAMP-specific
PHF1 PHD finger protein 1
PTPRT protein tyrosine phosphatase, receptor type, T
PYHIN1 pyrin and HIN domain family, member 1
RTCA RNA 3'-terminal phosphate cyclase
SH2D1A SH2 domain containing 1A
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD6 SMAD family member 6
SOCS3 suppressor of cytokine signaling 3
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRRT serrate, RNA effector molecule
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SYNGR4 synaptogyrin 4
TACR1 tachykinin receptor 1
TBX2 T-box 2
TFR2 transferrin receptor 2
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53I11 tumor protein p53 inducible protein 11
TTLL3 tubulin tyrosine ligase-like family member 3
UTS2 urotensin 2
WNT16 wingless-type MMTV integration site family, member 16
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFP64 ZFP64 zinc finger protein
ZNF224 zinc finger protein 224

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMT aminomethyltransferase
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARL15 ADP-ribosylation factor-like 15
ARSJ arylsulfatase family, member J
AXIN1 axin 1
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BMP15 bone morphogenetic protein 15
C17ORF80 chromosome 17 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
C1QTNF1 C1q and tumor necrosis factor related protein 1
C1R complement component 1, r subcomponent
C5ORF45 chromosome 5 open reading frame 45
CBX4 chromobox homolog 4
CCDC71 coiled-coil domain containing 71
CCP110 centriolar coiled coil protein 110kDa
CEP112 centrosomal protein 112kDa
CHM choroideremia (Rab escort protein 1)
CLGN calmegin
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COBL cordon-bleu WH2 repeat protein
CORO2A coronin, actin binding protein, 2A
CSF1R colony stimulating factor 1 receptor
CTSK cathepsin K
DEPTOR DEP domain containing MTOR-interacting protein
DHRS11 dehydrogenase/reductase (SDR family) member 11
DMTN dematin actin binding protein
EFNA3 ephrin-A3
EXOC6B exocyst complex component 6B
FAM155A family with sequence similarity 155, member A
FANCF Fanconi anemia, complementation group F
FBXL15 F-box and leucine-rich repeat protein 15
FBXL6 F-box and leucine-rich repeat protein 6
FBXL7 F-box and leucine-rich repeat protein 7
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GAN gigaxonin
GRAMD4 GRAM domain containing 4
GRTP1 growth hormone regulated TBC protein 1
HIST1H1D histone cluster 1, H1d
IFI35 interferon-induced protein 35
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT81 intraflagellar transport 81
IGFLR1 IGF-like family receptor 1
IL11RA interleukin 11 receptor, alpha
ISYNA1 inositol-3-phosphate synthase 1
ITK IL2-inducible T-cell kinase
KIAA0513 KIAA0513
KIAA1549L KIAA1549-like
LMNB2 lamin B2
MATN3 matrilin 3
MCMBP minichromosome maintenance complex binding protein
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MTMR12 myotubularin related protein 12
MVP major vault protein
NKX3-2 NK3 homeobox 2
NLE1 notchless homolog 1 (Drosophila)
NT5DC3 5'-nucleotidase domain containing 3
OCEL1 occludin/ELL domain containing 1
OSMR oncostatin M receptor
PALMD palmdelphin
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDH17 protocadherin 17
PDE8B phosphodiesterase 8B
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
POU3F2 POU class 3 homeobox 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RWDD2A RWD domain containing 2A
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCARA3 scavenger receptor class A, member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLITRK5 SLIT and NTRK-like family, member 5
SNHG3 small nucleolar RNA host gene 3
STX17 syntaxin 17
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TENM4 teneurin transmembrane protein 4
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TRDMT1 tRNA aspartic acid methyltransferase 1
TTC23 tetratricopeptide repeat domain 23
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
USB1 U6 snRNA biogenesis 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB48 zinc finger and BTB domain containing 48
ZNF286A zinc finger protein 286A
ZNF350 zinc finger protein 350
ZNF702P zinc finger protein 702, pseudogene
ZNF74 zinc finger protein 74
ZNF93 zinc finger protein 93
ZXDC ZXD family zinc finger C