ect2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description epithelial cell transforming 2|The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 1894)
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Genes

25 genes co-occuring with the biological term ect2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ARHGAP35 Rho GTPase activating protein 35
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CUX1 cut-like homeobox 1
E2F1 E2F transcription factor 1
ECT2 epithelial cell transforming 2
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
KIF23 kinesin family member 23
KIF3B kinesin family member 3B
KRT4 keratin 4, type II
MIR223 microRNA 223
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
PARD6A par-6 family cell polarity regulator alpha
PKP4 plakophilin 4
PLK1 polo-like kinase 1
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RACGAP1 Rac GTPase activating protein 1
RHOA ras homolog family member A
RHOB ras homolog family member B
TP53 tumor protein p53
TRIO trio Rho guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor