edrophonium chloride-1519 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the edrophonium chloride-1519 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADCK4 aarF domain containing kinase 4
AHNAK2 AHNAK nucleoprotein 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP26 Rho GTPase activating protein 26
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATAT1 alpha tubulin acetyltransferase 1
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
C19ORF40 chromosome 19 open reading frame 40
C1QL1 complement component 1, q subcomponent-like 1
C9ORF156 chromosome 9 open reading frame 156
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAPN9 calpain 9
CCL23 chemokine (C-C motif) ligand 23
CD53 CD53 molecule
CDC14B cell division cycle 14B
CEP152 centrosomal protein 152kDa
CEP41 centrosomal protein 41kDa
CEP97 centrosomal protein 97kDa
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COL11A2 collagen, type XI, alpha 2
CTIF CBP80/20-dependent translation initiation factor
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
EGR1 early growth response 1
EML2 echinoderm microtubule associated protein like 2
ENOX2 ecto-NOX disulfide-thiol exchanger 2
ESRRA estrogen-related receptor alpha
EXO5 exonuclease 5
FADS2 fatty acid desaturase 2
FAM46C family with sequence similarity 46, member C
FMO3 flavin containing monooxygenase 3
FOXN2 forkhead box N2
FSCN1 fascin actin-bundling protein 1
GPR137 G protein-coupled receptor 137
HCFC1 host cell factor C1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HR hair growth associated
IFNA16 interferon, alpha 16
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
LPXN leupaxin
MID1 midline 1
MR1 major histocompatibility complex, class I-related
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MST1 macrophage stimulating 1
MTA1 metastasis associated 1
MYOZ3 myozenin 3
N4BP3 NEDD4 binding protein 3
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEK1 NIMA-related kinase 1
NF1 neurofibromin 1
OVGP1 oviductal glycoprotein 1, 120kDa
PARVA parvin, alpha
PDIA2 protein disulfide isomerase family A, member 2
PICALM phosphatidylinositol binding clathrin assembly protein
PILRB paired immunoglobin-like type 2 receptor beta
POU4F1 POU class 4 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRODH proline dehydrogenase (oxidase) 1
PSAT1 phosphoserine aminotransferase 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBM5 RNA binding motif protein 5
REM1 RAS (RAD and GEM)-like GTP-binding 1
RSU1 Ras suppressor protein 1
S100A11 S100 calcium binding protein A11
S100A9 S100 calcium binding protein A9
SBNO1 strawberry notch homolog 1 (Drosophila)
SCAI suppressor of cancer cell invasion
SCN1B sodium channel, voltage gated, type I beta subunit
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC39A9 solute carrier family 39, member 9
SOS2 son of sevenless homolog 2 (Drosophila)
SOX12 SRY (sex determining region Y)-box 12
SYK spleen tyrosine kinase
SYMPK symplekin
TBC1D2 TBC1 domain family, member 2
TLDC1 TBC/LysM-associated domain containing 1
TMEM63A transmembrane protein 63A
TNPO2 transportin 2
TPP1 tripeptidyl peptidase I
TRIL TLR4 interactor with leucine-rich repeats
TUBA3C tubulin, alpha 3c
UBE3A ubiquitin protein ligase E3A
UGT8 UDP glycosyltransferase 8
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VAC14 Vac14 homolog (S. cerevisiae)
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ACYP2 acylphosphatase 2, muscle type
AKR1C3 aldo-keto reductase family 1, member C3
ARC activity-regulated cytoskeleton-associated protein
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARMC4 armadillo repeat containing 4
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
C11ORF63 chromosome 11 open reading frame 63
C22ORF29 chromosome 22 open reading frame 29
C3 complement component 3
C5AR2 complement component 5a receptor 2
C7ORF43 chromosome 7 open reading frame 43
CAMK1 calcium/calmodulin-dependent protein kinase I
CCNT1 cyclin T1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLCF1 cardiotrophin-like cytokine factor 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COG4 component of oligomeric golgi complex 4
CST6 cystatin E/M
CTSV cathepsin V
DEAF1 DEAF1 transcription factor
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFHD1 EF-hand domain family, member D1
EFNA3 ephrin-A3
ELMO3 engulfment and cell motility 3
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FAM102A family with sequence similarity 102, member A
FAM131A family with sequence similarity 131, member A
FLT4 fms-related tyrosine kinase 4
FOCAD focadhesin
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
FUZ fuzzy planar cell polarity protein
GLI3 GLI family zinc finger 3
GRB7 growth factor receptor-bound protein 7
GRPR gastrin-releasing peptide receptor
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2AJ histone cluster 1, H2aj
IFI35 interferon-induced protein 35
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCTD20 potassium channel tetramerization domain containing 20
LOC257152 uncharacterized LOC257152
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRP5 low density lipoprotein receptor-related protein 5
MMP9 matrix metallopeptidase 9
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
NES nestin
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NT5C 5', 3'-nucleotidase, cytosolic
NT5DC3 5'-nucleotidase domain containing 3
PACS1 phosphofurin acidic cluster sorting protein 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PECR peroxisomal trans-2-enoyl-CoA reductase
POM121 POM121 transmembrane nucleoporin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS16 protease, serine, 16 (thymus)
QTRT1 queuine tRNA-ribosyltransferase 1
RAB30 RAB30, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RHBDD3 rhomboid domain containing 3
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
S100A4 S100 calcium binding protein A4
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SETD8 SET domain containing (lysine methyltransferase) 8
SHARPIN SHANK-associated RH domain interactor
SIDT1 SID1 transmembrane family, member 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC41A3 solute carrier family 41, member 3
SLIT2 slit homolog 2 (Drosophila)
SMCO4 single-pass membrane protein with coiled-coil domains 4
SP1 Sp1 transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SULT4A1 sulfotransferase family 4A, member 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBX19 T-box 19
TESK2 testis-specific kinase 2
TFF2 trefoil factor 2
TMCC2 transmembrane and coiled-coil domain family 2
TMEM184C transmembrane protein 184C
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC13 trafficking protein particle complex 13
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TWF2 twinfilin actin binding protein 2
UBQLN4 ubiquilin 4
UPP1 uridine phosphorylase 1
USP20 ubiquitin specific peptidase 20
USP6 ubiquitin specific peptidase 6
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR25 WD repeat domain 25
ZBTB44 zinc finger and BTB domain containing 44
ZNF480 zinc finger protein 480
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76