eif4e Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description eukaryotic translation initiation factor 4E|The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 1977)
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Genes

59 genes co-occuring with the biological term eif4e in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGO2 argonaute RISC catalytic component 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
CCND1 cyclin D1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
HDAC2 histone deacetylase 2
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXA9 homeobox A9
HSPB2 heat shock 27kDa protein 2
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR141 microRNA 141
MIR497 microRNA 497
MKNK1 MAP kinase interacting serine/threonine kinase 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PABPC1 poly(A) binding protein, cytoplasmic 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PARN poly(A)-specific ribonuclease
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PML promyelocytic leukemia
PRKCA protein kinase C, alpha
RHOA ras homolog family member A
RND3 Rho family GTPase 3
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SNORD71 small nucleolar RNA, C/D box 71
SRSF1 serine/arginine-rich splicing factor 1
STK25 serine/threonine kinase 25
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TGFB1 transforming growth factor, beta 1
TLK1 tousled-like kinase 1
TNF tumor necrosis factor
TP53 tumor protein p53
TRIM22 tripartite motif containing 22
VEGFA vascular endothelial growth factor A
XPO1 exportin 1