elastic fiber Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description An extracellular matrix part that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. (Gene Ontology, GO_0071953)
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Genes

171 proteins co-occuring with the elastic fiber cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
ELN elastin 3.59273
FBLN5 fibulin 5 2.84151
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 2.80588
FBN1 fibrillin 1 2.70637
MFAP2 microfibrillar-associated protein 2 2.06559
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.05685
LOXL1 lysyl oxidase-like 1 2.03579
LOX lysyl oxidase 1.88141
FBN2 fibrillin 2 1.77079
EMILIN1 elastin microfibril interfacer 1 1.64852
LAX1 lymphocyte transmembrane adaptor 1 1.50622
MMP2 matrix metallopeptidase 2 1.50001
MMP12 matrix metallopeptidase 12 1.49775
MFAP5 microfibrillar associated protein 5 1.48362
MMP9 matrix metallopeptidase 9 1.45647
AAAS achalasia, adrenocortical insufficiency, alacrimia 1.42092
ELANE elastase, neutrophil expressed 1.37575
VCAN versican 1.36527
LTBP2 latent transforming growth factor beta binding protein 2 1.2996
FBLN1 fibulin 1 1.28943
FBLN2 fibulin 2 1.28356
FN1 fibronectin 1 1.21273
MFAP4 microfibrillar-associated protein 4 1.15211
LTBP3 latent transforming growth factor beta binding protein 3 1.0418
MMP1 matrix metallopeptidase 1 1.00695
GRHL1 grainyhead-like 1 (Drosophila) 0.99956
TNXA tenascin XA (pseudogene) 0.974198
TNXB tenascin XB 0.974198
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.950189
TNC tenascin C 0.917644
DCN decorin 0.914842
TIMP1 TIMP metallopeptidase inhibitor 1 0.906926
MGP matrix Gla protein 0.894868
SEBOX SEBOX homeobox 0.891169
CD34 CD34 molecule 0.884244
BGN biglycan 0.865826
TGFB1 transforming growth factor, beta 1 0.863528
APCS amyloid P component, serum 0.855717
LOXL2 lysyl oxidase-like 2 0.851124
AOC2 amine oxidase, copper containing 2 (retina-specific) 0.850665
GGCX gamma-glutamyl carboxylase 0.835515
CD68 CD68 molecule 0.806606
LTBP4 latent transforming growth factor beta binding protein 4 0.796062
MMP3 matrix metallopeptidase 3 0.793313
SPP1 secreted phosphoprotein 1 0.760433
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.750904
SPHKAP SPHK1 interactor, AKAP domain containing 0.746833
LTBP1 latent transforming growth factor beta binding protein 1 0.73287
MMP7 matrix metallopeptidase 7 0.728389
UBL7 ubiquitin-like 7 0.72258
LYZ lysozyme 0.712351
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.701744
EFS embryonal Fyn-associated substrate 0.69164
TIMP2 TIMP metallopeptidase inhibitor 2 0.686827
AOC3 amine oxidase, copper containing 3 0.631171
HBA1 hemoglobin, alpha 1 0.622229
TBRG1 transforming growth factor beta regulator 1 0.616285
HBA2 hemoglobin, alpha 2 0.615861
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.590973
SMAD2 SMAD family member 2 0.573828
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.558457
SCGB3A1 secretoglobin, family 3A, member 1 0.555559
MFAP1 microfibrillar-associated protein 1 0.553491
CTGF connective tissue growth factor 0.514493
CTSA cathepsin A 0.484886
CD79A CD79a molecule, immunoglobulin-associated alpha 0.483273
APOE apolipoprotein E 0.474018
CTSG cathepsin G 0.463198
MYH11 myosin, heavy chain 11, smooth muscle 0.463198
IVD isovaleryl-CoA dehydrogenase 0.457208
PDPN podoplanin 0.441312
ILVBL ilvB (bacterial acetolactate synthase)-like 0.440124
CELA1 chymotrypsin-like elastase family, member 1 0.431435
CELA3B chymotrypsin-like elastase family, member 3B 0.422389
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.415337
GORAB golgin, RAB6-interacting 0.414164
ALPL alkaline phosphatase, liver/bone/kidney 0.41221
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.408309
ST18 suppression of tumorigenicity 18, zinc finger 0.405971
FGD1 FYVE, RhoGEF and PH domain containing 1 0.399751
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.395485
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 0.389682
FMOD fibromodulin 0.389296
STK10 serine/threonine kinase 10 0.387751
CCL2 chemokine (C-C motif) ligand 2 0.385436
SCN3B sodium channel, voltage gated, type III beta subunit 0.380429
FGF2 fibroblast growth factor 2 (basic) 0.378891
SMOC1 SPARC related modular calcium binding 1 0.377738
ALPPL2 alkaline phosphatase, placental-like 2 0.366623
ALPP alkaline phosphatase, placental 0.365859
GLB1 galactosidase, beta 1 0.355563
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.353282
MMRN1 multimerin 1 0.352522
F8 coagulation factor VIII, procoagulant component 0.350243
ACAN aggrecan 0.347587
CTSS cathepsin S 0.347587
BMP2 bone morphogenetic protein 2 0.341907
CDSN corneodesmosin 0.336241
FGF18 fibroblast growth factor 18 0.334733
KHK ketohexokinase (fructokinase) 0.333602
SFTPD surfactant protein D 0.331719
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.330966
LUM lumican 0.327581
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 0.324576
NID2 nidogen 2 (osteonidogen) 0.32345
IL1B interleukin 1, beta 0.320077
COL1A2 collagen, type I, alpha 2 0.311105
BMP1 bone morphogenetic protein 1 0.309986
DNTT DNA nucleotidylexotransferase 0.307377
SCPEP1 serine carboxypeptidase 1 0.301797
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.301054
ACE angiotensin I converting enzyme 0.294748
SFTPC surfactant protein C 0.291787
NID1 nidogen 1 0.286245
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 0.285507
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.283295
FBN3 fibrillin 3 0.281453
SMOC2 SPARC related modular calcium binding 2 0.280349
EMILIN2 elastin microfibril interfacer 2 0.270434
PYCR1 pyrroline-5-carboxylate reductase 1 0.268603
CTSK cathepsin K 0.264946
MSX2 msh homeobox 2 0.26312
TBX20 T-box 20 0.262025
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.261296
PDGFA platelet-derived growth factor alpha polypeptide 0.258745
LOXL3 lysyl oxidase-like 3 0.258016
TGFBR1 transforming growth factor, beta receptor 1 0.255107
IGF1 insulin-like growth factor 1 (somatomedin C) 0.253653
CST2 cystatin SA 0.251839
ELP4 elongator acetyltransferase complex subunit 4 0.243879
PYCR2 pyrroline-5-carboxylate reductase family, member 2 0.240636
EGFL7 EGF-like-domain, multiple 7 0.239557
HOXA11 homeobox A11 0.237042
PYCRL pyrroline-5-carboxylate reductase-like 0.236683
VWF von Willebrand factor 0.236683
SOX18 SRY (sex determining region Y)-box 18 0.236324
AHSG alpha-2-HS-glycoprotein 0.234533
TSKU tsukushi, small leucine rich proteoglycan 0.227041
CLEC2A C-type lectin domain family 2, member A 0.222083
XYLT2 xylosyltransferase II 0.221025
ERCC6 excision repair cross-complementation group 6 0.21228
SFTPA1 surfactant protein A1 0.209858
IDUA iduronidase, alpha-L- 0.203022
THOP1 thimet oligopeptidase 1 0.202346
IFITM5 interferon induced transmembrane protein 5 0.200999
CD4 CD4 molecule 0.198325
STAC SH3 and cysteine rich domain 0.197993
FAM155B family with sequence similarity 155, member B 0.188274
CD44 CD44 molecule (Indian blood group) 0.18516
ANKH ANKH inorganic pyrophosphate transport regulator 0.183328
TTR transthyretin 0.180045
PCNA proliferating cell nuclear antigen 0.178877
AMBP alpha-1-microglobulin/bikunin precursor 0.177154
DAND5 DAN domain family member 5, BMP antagonist 0.175745
LDLR low density lipoprotein receptor 0.173543
TAC1 tachykinin, precursor 1 0.173273
XYLT1 xylosyltransferase I 0.16935
RUNX2 runt-related transcription factor 2 0.169099
CALCA calcitonin-related polypeptide alpha 0.168598
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.168598
PTH1R parathyroid hormone 1 receptor 0.168598
ELSPBP1 epididymal sperm binding protein 1 0.165463
PROX1 prospero homeobox 1 0.165
NOS3 nitric oxide synthase 3 (endothelial cell) 0.164542
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.164315
LGALS3 lectin, galactoside-binding, soluble, 3 0.1632
PTPRK protein tyrosine phosphatase, receptor type, K 0.160658
HMX2 H6 family homeobox 2 0.159856
IL1R1 interleukin 1 receptor, type I 0.158882
INS insulin 0.158502
GDF11 growth differentiation factor 11 0.157578