ellipticine-1765 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the ellipticine-1765 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BMI1 BMI1 proto-oncogene, polycomb ring finger
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CD2AP CD2-associated protein
CEL carboxyl ester lipase
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHMP2B charged multivesicular body protein 2B
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLDN15 claudin 15
CLP1 cleavage and polyadenylation factor I subunit 1
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CRY1 cryptochrome circadian clock 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYLD cylindromatosis (turban tumor syndrome)
DCAF6 DDB1 and CUL4 associated factor 6
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EGLN1 egl-9 family hypoxia-inducible factor 1
EGR2 early growth response 2
EMC8 ER membrane protein complex subunit 8
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FZD7 frizzled class receptor 7
GCH1 GTP cyclohydrolase 1
GOLT1B golgi transport 1B
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HBS1L HBS1-like translational GTPase
HEXIM1 hexamethylene bis-acetamide inducible 1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HSBP1 heat shock factor binding protein 1
HSPA14 heat shock 70kDa protein 14
IFIH1 interferon induced with helicase C domain 1
IFITM3 interferon induced transmembrane protein 3
ITGB5 integrin, beta 5
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LMNA lamin A/C
LSM1 LSM1, U6 small nuclear RNA associated
MAGED2 melanoma antigen family D2
MED6 mediator complex subunit 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPV17 MpV17 mitochondrial inner membrane protein
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
N4BP2L2 NEDD4 binding protein 2-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCOA3 nuclear receptor coactivator 3
NFYB nuclear transcription factor Y, beta
NINJ2 ninjurin 2
NPTXR neuronal pentraxin receptor
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NXF1 nuclear RNA export factor 1
OAT ornithine aminotransferase
OSTM1 osteopetrosis associated transmembrane protein 1
PISD phosphatidylserine decarboxylase
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PPP6C protein phosphatase 6, catalytic subunit
PRDM2 PR domain containing 2, with ZNF domain
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRPF4B pre-mRNA processing factor 4B
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PTX3 pentraxin 3, long
RBBP6 retinoblastoma binding protein 6
RSL1D1 ribosomal L1 domain containing 1
RSRP1 arginine/serine-rich protein 1
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
ST20 suppressor of tumorigenicity 20
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TCF4 transcription factor 4
TOB1 transducer of ERBB2, 1
TOP1 topoisomerase (DNA) I
TRAPPC10 trafficking protein particle complex 10
TUBA4B tubulin, alpha 4b
UBL3 ubiquitin-like 3
UBL5 ubiquitin-like 5
UGDH UDP-glucose 6-dehydrogenase
WASF1 WAS protein family, member 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB11 zinc finger and BTB domain containing 11
ZBTB18 zinc finger and BTB domain containing 18
ZC2HC1A zinc finger, C2HC-type containing 1A
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF432 zinc finger protein 432
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABHD11 abhydrolase domain containing 11
ADM adrenomedullin
ADNP activity-dependent neuroprotector homeobox
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ATF4 activating transcription factor 4
BAG1 BCL2-associated athanogene
BCKDK branched chain ketoacid dehydrogenase kinase
BCOR BCL6 corepressor
C17ORF62 chromosome 17 open reading frame 62
C7ORF49 chromosome 7 open reading frame 49
CAMLG calcium modulating ligand
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CD14 CD14 molecule
CD83 CD83 molecule
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CLEC7A C-type lectin domain family 7, member A
COG2 component of oligomeric golgi complex 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R1 cytochrome b5 reductase 1
DDIT4 DNA-damage-inducible transcript 4
EAF2 ELL associated factor 2
EIF4A2 eukaryotic translation initiation factor 4A2
EMC2 ER membrane protein complex subunit 2
EXOC3 exocyst complex component 3
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FPGT fucose-1-phosphate guanylyltransferase
GMIP GEM interacting protein
GTPBP2 GTP binding protein 2
H1FX H1 histone family, member X
HEATR3 HEAT repeat containing 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IMP4 IMP4, U3 small nucleolar ribonucleoprotein
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIAA0020 KIAA0020
KIF11 kinesin family member 11
KIF21B kinesin family member 21B
LPAR6 lysophosphatidic acid receptor 6
LRRC8D leucine rich repeat containing 8 family, member D
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP7D1 MAP7 domain containing 1
MGA MGA, MAX dimerization protein
MINA MYC induced nuclear antigen
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MSMO1 methylsterol monooxygenase 1
MSRB1 methionine sulfoxide reductase B1
MT1E metallothionein 1E
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTMR4 myotubularin related protein 4
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEIL3 nei endonuclease VIII-like 3 (E. coli)
PAGR1 PAXIP1 associated glutamate-rich protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCYOX1L prenylcysteine oxidase 1 like
PEX2 peroxisomal biogenesis factor 2
PLCD1 phospholipase C, delta 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAN peter pan homolog (Drosophila)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RNF187 ring finger protein 187
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX1-IT1 RUNX1 intronic transcript 1
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
SNX17 sorting nexin 17
STARD7 StAR-related lipid transfer (START) domain containing 7
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM251 transmembrane protein 251
TNF tumor necrosis factor
TNS3 tensin 3
TOR1A torsin family 1, member A (torsin A)
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
WDR5B WD repeat domain 5B
XPOT exportin, tRNA
ZDHHC4 zinc finger, DHHC-type containing 4
ZNF267 zinc finger protein 267
ZNF85 zinc finger protein 85