embryonal rhabdomyosarcoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A form of RHABDOMYOSARCOMA arising primarily in the head and neck, especially the orbit, of children below the age of 10. The cells are smaller than those of other rhabdomyosarcomas and are of two basic cell types: spindle cells and round cells. This cancer is highly sensitive to chemotherapy and has a high cure rate with multi-modality therapy. (From Holland et al., Cancer Medicine, 3d ed, p2188)|A poorly circumscribed morphologic variant of rhabdomyosarcoma. It is characterized by the presence of primitive skeletal muscle differentiation in any stage of myogenesis. There are three histologic types, spindle cell, botryoid and anaplastic. (Experimental Factor Ontology, EFO_0000437)
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Genes

110 genes co-occuring with the disease embryonal rhabdomyosarcoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MYOG myogenin (myogenic factor 4) 2.12418
PAX3 paired box 3 1.98808
MYOD1 myogenic differentiation 1 1.98436
PAX7 paired box 7 1.87929
MB myoglobin 1.63724
RDM1 RAD52 motif containing 1 1.52688
TSRM zinc finger domain-related protein TSRM 1.36814
MYF5 myogenic factor 5 1.34417
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 1.27563
FOXO1 forkhead box O1 1.22779
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 1.1422
EML5 echinoderm microtubule associated protein like 5 1.12403
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 1.08999
RHD Rh blood group, D antigen 1.01934
IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker) 1.00414
CALD1 caldesmon 1 0.990222
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 0.892538
ENO2 enolase 2 (gamma, neuronal) 0.876966
DICER1 dicer 1, ribonuclease type III 0.870825
MYF6 myogenic factor 6 (herculin) 0.861409
GLI1 GLI family zinc finger 1 0.792131
KIF18A kinesin family member 18A 0.779432
NCOA2 nuclear receptor coactivator 2 0.748017
IGF2 insulin-like growth factor 2 0.730166
NCOA1 nuclear receptor coactivator 1 0.727738
PTCH1 patched 1 0.711989
WT1 Wilms tumor 1 0.708364
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.694702
TP53 tumor protein p53 0.689092
YAP1 Yes-associated protein 1 0.679499
MSC musculin 0.671925
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) 0.640645
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.633956
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.621008
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.617877
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.610838
STIM2 stromal interaction molecule 2 0.610448
CD99 CD99 molecule 0.585108
EIF4B eukaryotic translation initiation factor 4B 0.571884
EWSR1 EWS RNA-binding protein 1 0.555568
CD34 CD34 molecule 0.540442
WNT6 wingless-type MMTV integration site family, member 6 0.524974
GPC5 glypican 5 0.510344
LRP1B low density lipoprotein receptor-related protein 1B 0.487027
SLC16A4 solute carrier family 16, member 4 0.483985
GLI3 GLI family zinc finger 3 0.480945
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.469576
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.466172
ULBP2 UL16 binding protein 2 0.459373
CKM creatine kinase, muscle 0.458241
SOS1 son of sevenless homolog 1 (Drosophila) 0.445052
ILK integrin-linked kinase 0.415773
FGFR4 fibroblast growth factor receptor 4 0.410161
TDP1 tyrosyl-DNA phosphodiesterase 1 0.406798
DUX4L8 double homeobox 4 like 8 0.393001
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.390769
HHIP hedgehog interacting protein 0.389653
ALK anaplastic lymphoma receptor tyrosine kinase 0.387794
SUFU suppressor of fused homolog (Drosophila) 0.384451
EPHA3 EPH receptor A3 0.380739
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.374809
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.365562
HRAS Harvey rat sarcoma viral oncogene homolog 0.365193
DUX4L6 double homeobox 4 like 6 0.354131
ETV6 ets variant 6 0.348981
NF1 neurofibromin 1 0.344574
FRS2 fibroblast growth factor receptor substrate 2 0.33066
POSTN periostin, osteoblast specific factor 0.3292
SHH sonic hedgehog 0.318272
COPS5 COP9 signalosome subunit 5 0.315003
CDK4 cyclin-dependent kinase 4 0.313189
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.304503
AFP alpha-fetoprotein 0.300533
TYROBP TYRO protein tyrosine kinase binding protein 0.300173
SYP synaptophysin 0.295492
MYEF2 myelin expression factor 2 0.288668
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.287235
GFAP glial fibrillary acidic protein 0.285444
THBS2 thrombospondin 2 0.285086
DUSP6 dual specificity phosphatase 6 0.282582
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.282225
EFNA1 ephrin-A1 0.274021
ENDOG endonuclease G 0.272241
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.27153
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.270108
NEB nebulin 0.266558
ADAM12 ADAM metallopeptidase domain 12 0.266203
TOP1 topoisomerase (DNA) I 0.253831
WNT2 wingless-type MMTV integration site family member 2 0.25207
PCCA propionyl CoA carboxylase, alpha polypeptide 0.237706
SSX1 synovial sarcoma, X breakpoint 1 0.235268
AHCY adenosylhomocysteinase 0.233183
PTPRC protein tyrosine phosphatase, receptor type, C 0.230755
SOX2 SRY (sex determining region Y)-box 2 0.227297
SFRP2 secreted frizzled-related protein 2 0.195183
JUP junction plakoglobin 0.193285
JUN jun proto-oncogene 0.187719
SMAD4 SMAD family member 4 0.18621
YBX1 Y box binding protein 1 0.180084
HTRA2 HtrA serine peptidase 2 0.170789
DCAF7 DDB1 and CUL4 associated factor 7 0.169571
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.163729
IGFBP5 insulin-like growth factor binding protein 5 0.162707
FGFR1 fibroblast growth factor receptor 1 0.161523
COL3A1 collagen, type III, alpha 1 0.159658
HMGA1 high mobility group AT-hook 1 0.158951
AGO2 argonaute RISC catalytic component 2 0.14406
TTN titin 0.143462
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.140952
MMP1 matrix metallopeptidase 1 0.137694