emphysema Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A subcategory of chronic obstructive pulmonary disease (COPD). It occurs in people who smoke and suffer from chronic bronchitis. It is characterized by inflation of the alveoli, alveolar wall damage, and reduction in the number of alveoli, resulting in difficulty breathing. (Experimental Factor Ontology, EFO_0000464)
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Genes

78 genes co-occuring with the biological term emphysema in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
AGER advanced glycosylation end product-specific receptor
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AMOTL1 angiomotin like 1
APOM apolipoprotein M
BAX BCL2-associated X protein
BICD1 bicaudal D homolog 1 (Drosophila)
CCL5 chemokine (C-C motif) ligand 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLPTM1L CLPTM1-like
CTSG cathepsin G
CTSL cathepsin L
CTSS cathepsin S
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
EGF epidermal growth factor
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBN1 fibrillin 1
FGF2 fibroblast growth factor 2 (basic)
FGF7 fibroblast growth factor 7
FGFR2 fibroblast growth factor receptor 2
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GC group-specific component (vitamin D binding protein)
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IFNG interferon, gamma
IL15 interleukin 15
IL16 interleukin 16
IL17A interleukin 17A
IL1RN interleukin 1 receptor antagonist
ITGB6 integrin, beta 6
JUN jun proto-oncogene
MCAM melanoma cell adhesion molecule
MET MET proto-oncogene, receptor tyrosine kinase
MIR34C microRNA 34c
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
NREP neuronal regeneration related protein
PCNA proliferating cell nuclear antigen
PPARG peroxisome proliferator-activated receptor gamma
PRTN3 proteinase 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTMA prothymosin, alpha
RAP1A RAP1A, member of RAS oncogene family
RORA RAR-related orphan receptor A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPD surfactant protein D
SIRT1 sirtuin 1
SOD3 superoxide dismutase 3, extracellular
SPP1 secreted phosphoprotein 1
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TREM2 triggering receptor expressed on myeloid cells 2
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A