emt Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. (Gene Ontology, GO_0001837)
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Genes

305 genes co-occuring with the biological term emt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACVR1B activin A receptor, type IB
ADIPOQ adiponectin, C1Q and collagen domain containing
AHR aryl hydrocarbon receptor
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKTIP AKT interacting protein
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
ALX1 ALX homeobox 1
ARHGAP21 Rho GTPase activating protein 21
AURKA aurora kinase A
AXIN2 axin 2
AXL AXL receptor tyrosine kinase
BAG3 BCL2-associated athanogene 3
BATF2 basic leucine zipper transcription factor, ATF-like 2
BCL2L1 BCL2-like 1
BIRC2 baculoviral IAP repeat containing 2
BIRC7 baculoviral IAP repeat containing 7
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
BRCA1 breast cancer 1, early onset
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BSG basigin (Ok blood group)
C3 complement component 3
CA9 carbonic anhydrase IX
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CCND1 cyclin D1
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CGN cingulin
CKB creatine kinase, brain
CLDN1 claudin 1
CLDN4 claudin 4
CLU clusterin
COL1A1 collagen, type I, alpha 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCLK1 doublecortin-like kinase 1
DDR2 discoidin domain receptor tyrosine kinase 2
DEDD death effector domain containing
DKK1 dickkopf WNT signaling pathway inhibitor 1
DVL2 dishevelled segment polarity protein 2
EDN1 endothelin 1
EDNRA endothelin receptor type A
EED embryonic ectoderm development
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESRP1 epithelial splicing regulatory protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV4 ets variant 4
ETV5 ets variant 5
EZR ezrin
FAS Fas cell surface death receptor
FGF2 fibroblast growth factor 2 (basic)
FGL2 fibrinogen-like 2
FHL2 four and a half LIM domains 2
FLT1 fms-related tyrosine kinase 1
FMNL2 formin-like 2
FOXA1 forkhead box A1
FOXA2 forkhead box A2
FOXF1 forkhead box F1
FOXJ2 forkhead box J2
FOXM1 forkhead box M1
FOXQ1 forkhead box Q1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD4 frizzled class receptor 4
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GFER growth factor, augmenter of liver regeneration
GJA1 gap junction protein, alpha 1, 43kDa
GKN1 gastrokine 1
GLI1 GLI family zinc finger 1
GPR32 G protein-coupled receptor 32
GREM1 gremlin 1, DAN family BMP antagonist
GRHL2 grainyhead-like 2 (Drosophila)
GSK3B glycogen synthase kinase 3 beta
HBEGF heparin-binding EGF-like growth factor
HDGF hepatoma-derived growth factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA2 high mobility group AT-hook 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOTAIR HOX transcript antisense RNA
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP7 insulin-like growth factor binding protein 7
IL6 interleukin 6
ILK integrin-linked kinase
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB5 integrin, beta 5
JUN jun proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF17 Kruppel-like factor 17
KLF5 Kruppel-like factor 5 (intestinal)
KLK10 kallikrein-related peptidase 10
L1CAM L1 cell adhesion molecule
LBX1 ladybird homeobox 1
LHX2 LIM homeobox 2
LIN28A lin-28 homolog A (C. elegans)
LINC-ROR long intergenic non-protein coding RNA, regulator of reprogramming
LOXL2 lysyl oxidase-like 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCAM melanoma cell adhesion molecule
MIR101-1 microRNA 101-1
MIR106B microRNA 106b
MIR134 microRNA 134
MIR148A microRNA 148a
MIR150 microRNA 150
MIR155 microRNA 155
MIR17 microRNA 17
MIR181A1 microRNA 181a-1
MIR200A microRNA 200a
MIR200B microRNA 200b
MIR200C microRNA 200c
MIR203A microRNA 203a
MIR205 microRNA 205
MIR21 microRNA 21
MIR217 microRNA 217
MIR22 microRNA 22
MIR221 microRNA 221
MIR222 microRNA 222
MIR26B microRNA 26b
MIR27B microRNA 27b
MIR30A microRNA 30a
MIR34A microRNA 34a
MIR375 microRNA 375
MIR429 microRNA 429
MIR506 microRNA 506
MIR520G microRNA 520g
MIR661 microRNA 661
MIR7-1 microRNA 7-1
MIR888 microRNA 888
MIRLET7D microRNA let-7d
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSN moesin
MST1 macrophage stimulating 1
MST1R macrophage stimulating 1 receptor
MTA1 metastasis associated 1
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NANOG Nanog homeobox
NBN nibrin
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX2-1 NK2 homeobox 1
NOTCH1 notch 1
NOTCH2 notch 2
NOV nephroblastoma overexpressed
NOX1 NADPH oxidase 1
NRG1 neuregulin 1
NRP1 neuropilin 1
NTN1 netrin 1
ONECUT1 one cut homeobox 1
ONECUT2 one cut homeobox 2
OPRM1 opioid receptor, mu 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PALLD palladin, cytoskeletal associated protein
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFB platelet-derived growth factor beta polypeptide
PDGFD platelet derived growth factor D
PEBP1 phosphatidylethanolamine binding protein 1
PER2 period circadian clock 2
PIAS4 protein inhibitor of activated STAT, 4
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAC8 placenta-specific 8
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
POMC proopiomelanocortin
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PROM1 prominin 1
PRRX1 paired related homeobox 1
PTEN phosphatase and tensin homolog
PTHLH parathyroid hormone-like hormone
PTK2B protein tyrosine kinase 2 beta
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTTG1 pituitary tumor-transforming 1
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RNH1 ribonuclease/angiogenin inhibitor 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDC1 syndecan 1
SDC2 syndecan 2
SDHAF2 succinate dehydrogenase complex assembly factor 2
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFRP1 secreted frizzled-related protein 1
SFRP5 secreted frizzled-related protein 5
SGPP1 sphingosine-1-phosphate phosphatase 1
SHOX2 short stature homeobox 2
SIRT1 sirtuin 1
SIX1 SIX homeobox 1
SKIL SKI-like proto-oncogene
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SOX17 SRY (sex determining region Y)-box 17
SOX4 SRY (sex determining region Y)-box 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR2A small proline-rich protein 2A
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STARD10 StAR-related lipid transfer (START) domain containing 10
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIM1 stromal interaction molecule 1
T T, brachyury homolog (mouse)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBX1 T-box 1
TBX2 T-box 2
TDGF1 teratocarcinoma-derived growth factor 1
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TMPRSS4 transmembrane protease, serine 4
TNF tumor necrosis factor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TP63 tumor protein p63
TPM3 tropomyosin 3
TRIM33 tripartite motif containing 33
TRIM62 tripartite motif containing 62
TUBA1B tubulin, alpha 1b
TWIST1 twist family bHLH transcription factor 1
TWIST2 twist family bHLH transcription factor 2
USP9X ubiquitin specific peptidase 9, X-linked
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
WASF3 WAS protein family, member 3
WISP2 WNT1 inducible signaling pathway protein 2
WNT5A wingless-type MMTV integration site family, member 5A
YY1 YY1 transcription factor
ZBTB33 zinc finger and BTB domain containing 33
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2
ZNF217 zinc finger protein 217