enalapril-7265 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the enalapril-7265 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK2 aarF domain containing kinase 2
AHI1 Abelson helper integration site 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANP32A-IT1 ANP32A intronic transcript 1
ARMCX2 armadillo repeat containing, X-linked 2
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD47 CD47 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNTNAP2 contactin associated protein-like 2
COX4I1 cytochrome c oxidase subunit IV isoform 1
CSPP1 centrosome and spindle pole associated protein 1
CTSK cathepsin K
CXCL3 chemokine (C-X-C motif) ligand 3
DAGLA diacylglycerol lipase, alpha
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ESRRA estrogen-related receptor alpha
F3 coagulation factor III (thromboplastin, tissue factor)
FGF13 fibroblast growth factor 13
FLJ10038 uncharacterized protein FLJ10038
FLOT2 flotillin 2
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GLRB glycine receptor, beta
GOLGA1 golgin A1
GPC3 glypican 3
GTF2I general transcription factor IIi
HIST1H1T histone cluster 1, H1t
HOMER2 homer scaffolding protein 2
HPS4 Hermansky-Pudlak syndrome 4
ING2 inhibitor of growth family, member 2
ITGB7 integrin, beta 7
JAG2 jagged 2
KCTD20 potassium channel tetramerization domain containing 20
LHX2 LIM homeobox 2
LNPEP leucyl/cystinyl aminopeptidase
LY6D lymphocyte antigen 6 complex, locus D
LZTR1 leucine-zipper-like transcription regulator 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPK12 mitogen-activated protein kinase 12
MAPK14 mitogen-activated protein kinase 14
MARK4 MAP/microtubule affinity-regulating kinase 4
MBNL2 muscleblind-like splicing regulator 2
MFSD6 major facilitator superfamily domain containing 6
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MOCS3 molybdenum cofactor synthesis 3
MTUS1 microtubule associated tumor suppressor 1
MYRF myelin regulatory factor
NCKAP1 NCK-associated protein 1
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NF2 neurofibromin 2 (merlin)
NNMT nicotinamide N-methyltransferase
NRP1 neuropilin 1
OCA2 oculocutaneous albinism II
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PHLDA3 pleckstrin homology-like domain, family A, member 3
PICALM phosphatidylinositol binding clathrin assembly protein
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PKNOX1 PBX/knotted 1 homeobox 1
PLAG1 pleiomorphic adenoma gene 1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RANBP1 RAN binding protein 1
REEP2 receptor accessory protein 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNFT1 ring finger protein, transmembrane 1
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RUSC2 RUN and SH3 domain containing 2
SCAI suppressor of cancer cell invasion
SCARB2 scavenger receptor class B, member 2
SIRT3 sirtuin 3
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
SS18 synovial sarcoma translocation, chromosome 18
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STX7 syntaxin 7
TAOK2 TAO kinase 2
TMEM120B transmembrane protein 120B
TNPO3 transportin 3
TRIM14 tripartite motif containing 14
TTLL1 tubulin tyrosine ligase-like family member 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
WT1 Wilms tumor 1
WWC1 WW and C2 domain containing 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF134 zinc finger protein 134
ZNF165 zinc finger protein 165
ZNF274 zinc finger protein 274
ZNF408 zinc finger protein 408

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ANAPC2 anaphase promoting complex subunit 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AXIN1 axin 1
BCORL1 BCL6 corepressor-like 1
BDNF brain-derived neurotrophic factor
C1ORF115 chromosome 1 open reading frame 115
C1R complement component 1, r subcomponent
CCDC101 coiled-coil domain containing 101
CCDC25 coiled-coil domain containing 25
CCNJL cyclin J-like
CCRL2 chemokine (C-C motif) receptor-like 2
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DET1 de-etiolated homolog 1 (Arabidopsis)
EGLN2 egl-9 family hypoxia-inducible factor 2
EN1 engrailed homeobox 1
EPHA4 EPH receptor A4
ERN2 endoplasmic reticulum to nucleus signaling 2
EVPL envoplakin
F8 coagulation factor VIII, procoagulant component
FAM53B family with sequence similarity 53, member B
FGD1 FYVE, RhoGEF and PH domain containing 1
FIG4 FIG4 phosphoinositide 5-phosphatase
FSTL3 follistatin-like 3 (secreted glycoprotein)
GLCE glucuronic acid epimerase
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR176 G protein-coupled receptor 176
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2AJ histone cluster 1, H2aj
HIST1H3G histone cluster 1, H3g
HLA-J major histocompatibility complex, class I, J (pseudogene)
HLX H2.0-like homeobox
HYAL3 hyaluronoglucosaminidase 3
KRBOX4 KRAB box domain containing 4
KRT15 keratin 15, type I
LHFP lipoma HMGIC fusion partner
LIMS2 LIM and senescent cell antigen-like domains 2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MCM9 minichromosome maintenance complex component 9
MISP mitotic spindle positioning
MTRF1 mitochondrial translational release factor 1
MUM1 melanoma associated antigen (mutated) 1
MXD3 MAX dimerization protein 3
MXRA8 matrix-remodelling associated 8
MYO19 myosin XIX
NAG18 NAG18 mRNA
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NKX3-2 NK3 homeobox 2
NME3 NME/NM23 nucleoside diphosphate kinase 3
ODF2 outer dense fiber of sperm tails 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OSMR oncostatin M receptor
PARD6A par-6 family cell polarity regulator alpha
PDE8B phosphodiesterase 8B
PIAS3 protein inhibitor of activated STAT, 3
PILRB paired immunoglobin-like type 2 receptor beta
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPAN peter pan homolog (Drosophila)
PRICKLE3 prickle homolog 3 (Drosophila)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RASA2 RAS p21 protein activator 2
RHOB ras homolog family member B
RNF126P1 ring finger protein 126 pseudogene 1
RPGR retinitis pigmentosa GTPase regulator
RPL23AP32 ribosomal protein L23a pseudogene 32
SERINC5 serine incorporator 5
SFXN1 sideroflexin 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SPEG SPEG complex locus
STARD13 StAR-related lipid transfer (START) domain containing 13
SYF2 SYF2 pre-mRNA-splicing factor
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TGFB3 transforming growth factor, beta 3
THOC6 THO complex 6
TIGD6 tigger transposable element derived 6
TMC5 transmembrane channel-like 5
TMEM132A transmembrane protein 132A
TMEM159 transmembrane protein 159
TMEM209 transmembrane protein 209
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TOLLIP toll interacting protein
TRAF5 TNF receptor-associated factor 5
TRAIP TRAF interacting protein
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
USP27X ubiquitin specific peptidase 27, X-linked
XAB2 XPA binding protein 2
ZNF227 zinc finger protein 227
ZNF230 zinc finger protein 230
ZNF282 zinc finger protein 282
ZNF415 zinc finger protein 415
ZNF770 zinc finger protein 770
ZSCAN31 zinc finger and SCAN domain containing 31