endocarditis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A heart disease involving non-infectious inflammation of the endocardium (inner layer of the heart).|Inflammation of the inner lining of the heart (ENDOCARDIUM), the continuous membrane lining the four chambers and HEART VALVES. It is often caused by microorganisms including bacteria, viruses, fungi, and rickettsiae. Left untreated, endocarditis can damage heart valves and become life-threatening.|Inflammation of the endocardium. (Experimental Factor Ontology, EFO_0000465)
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Genes

262 genes co-occuring with the disease endocarditis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
FN1 fibronectin 1 1.63008
CRP C-reactive protein, pentraxin-related 1.51721
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 1.45924
PRTN3 proteinase 3 1.2508
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.21435
F3 coagulation factor III (thromboplastin, tissue factor) 1.20613
AMDHD2 amidohydrolase domain containing 2 1.19229
MATK megakaryocyte-associated tyrosine kinase 1.16735
DLL1 delta-like 1 (Drosophila) 1.1473
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 1.12741
SUMF2 sulfatase modifying factor 2 1.08873
CD79A CD79a molecule, immunoglobulin-associated alpha 1.07908
F2 coagulation factor II (thrombin) 1.05513
PMS2P1 postmeiotic segregation increased 2 pseudogene 1 1.05093
RTP4 receptor (chemosensory) transporter protein 4 1.00119
CS citrate synthase 0.98011
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.975482
CD4 CD4 molecule 0.964148
LECT1 leukocyte cell derived chemotaxin 1 0.955361
CAT catalase 0.94577
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 0.924213
PRF1 perforin 1 (pore forming protein) 0.920498
MTM1 myotubularin 1 0.905265
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.899103
LNX2 ligand of numb-protein X 2 0.876148
IVD isovaleryl-CoA dehydrogenase 0.841753
FBXO21 F-box protein 21 0.813052
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.81018
GLRXP3 glutaredoxin (thioltransferase) pseudogene 3 0.803616
PLAT plasminogen activator, tissue 0.778613
ALB albumin 0.770027
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.750864
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.741923
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 0.722077
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.717232
CCDC112 coiled-coil domain containing 112 0.704742
C1QBP complement component 1, q subcomponent binding protein 0.703536
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.694301
NEUROD4 neuronal differentiation 4 0.689492
NLRC5 NLR family, CARD domain containing 5 0.6791
OR6B2 olfactory receptor, family 6, subfamily B, member 2 0.675112
LBP lipopolysaccharide binding protein 0.649323
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.638282
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.62885
PLEK2 pleckstrin 2 0.625319
PIDD1 p53-induced death domain protein 1 0.619051
AQP9 aquaporin 9 0.617486
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.607323
TMEM131 transmembrane protein 131 0.594843
MSRA methionine sulfoxide reductase A 0.591727
GPR84 G protein-coupled receptor 84 0.588222
IL6 interleukin 6 0.587054
SLURP1 secreted LY6/PLAUR domain containing 1 0.587054
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.58433
ESYT1 extended synaptotagmin-like protein 1 0.582384
HPR haptoglobin-related protein 0.581606
LYZ lysozyme 0.564889
ST20 suppressor of tumorigenicity 20 0.564112
ERAS ES cell expressed Ras 0.557509
AGRN agrin 0.544318
F5 coagulation factor V (proaccelerin, labile factor) 0.540442
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.529994
ARRDC3 arrestin domain containing 3 0.528835
HP haptoglobin 0.52729
FAM155B family with sequence similarity 155, member B 0.526518
PCSK6 proprotein convertase subtilisin/kexin type 6 0.523045
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.522273
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.51919
F12 coagulation factor XII (Hageman factor) 0.514186
APEH acylaminoacyl-peptide hydrolase 0.512264
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.507273
ICAM1 intercellular adhesion molecule 1 0.503058
APOH apolipoprotein H (beta-2-glycoprotein I) 0.498085
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.495411
VCAM1 vascular cell adhesion molecule 1 0.491978
TNNI3 troponin I type 3 (cardiac) 0.491215
LCK LCK proto-oncogene, Src family tyrosine kinase 0.48893
PEX19 peroxisomal biogenesis factor 19 0.488549
ARMC10 armadillo repeat containing 10 0.487788
SSRP1 structure specific recognition protein 1 0.476014
EMC3 ER membrane protein complex subunit 3 0.473361
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.465794
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 0.463527
FAM120A family with sequence similarity 120A 0.452208
FBN1 fibrillin 1 0.451454
TNMD tenomodulin 0.450324
LEFTY1 left-right determination factor 1 0.449194
CCNE1 cyclin E1 0.446182
PLG plasminogen 0.445805
BTNL2 butyrophilin-like 2 0.443547
SCPEP1 serine carboxypeptidase 1 0.442042
TNF tumor necrosis factor 0.440914
NEUROD2 neuronal differentiation 2 0.440914
PRB3 proline-rich protein BstNI subfamily 3 0.434524
FIP1L1 factor interacting with PAPOLA and CPSF1 0.433397
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.427015
SRPX2 sushi-repeat containing protein, X-linked 2 0.424014
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.42139
SCIN scinderin 0.419142
MPO myeloperoxidase 0.413901
CNOT8 CCR4-NOT transcription complex, subunit 8 0.40904
OR5K1 olfactory receptor, family 5, subfamily K, member 1 0.408666
PER2 period circadian clock 2 0.407919
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 0.406051
OR3A1 olfactory receptor, family 3, subfamily A, member 1 0.405305
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.405305
IL10 interleukin 10 0.402692
MUC21 mucin 21, cell surface associated 0.397843
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.389281
F8 coagulation factor VIII, procoagulant component 0.388909
IL16 interleukin 16 0.388909
ALLC allantoicase 0.386308
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.384451
JMJD6 jumonji domain containing 6 0.384079
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.381852
PTCH1 patched 1 0.38111
EPX eosinophil peroxidase 0.379626
NQO2 NAD(P)H dehydrogenase, quinone 2 0.37629
WDFY2 WD repeat and FYVE domain containing 2 0.373328
MARCO macrophage receptor with collagenous structure 0.365193
CNOT1 CCR4-NOT transcription complex, subunit 1 0.358551
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.357814
GNPDA1 glucosamine-6-phosphate deaminase 1 0.355235
RNF19B ring finger protein 19B 0.353763
PRIMA1 proline rich membrane anchor 1 0.352659
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.349349
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.347144
ENO1 enolase 1, (alpha) 0.34384
CDAN1 codanin 1 0.343106
PER1 period circadian clock 1 0.339806
VWF von Willebrand factor 0.337242
SECISBP2 SECIS binding protein 2 0.335412
RND3 Rho family GTPase 3 0.334681
TOX thymocyte selection-associated high mobility group box 0.332852
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.329565
MTUS1 microtubule associated tumor suppressor 1 0.32701
CXCL8 chemokine (C-X-C motif) ligand 8 0.324094
TBX1 T-box 1 0.32373
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.321545
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.317545
LTF lactotransferrin 0.316456
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.307395
CXCL16 chemokine (C-X-C motif) ligand 16 0.304503
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.300173
CCL23 chemokine (C-C motif) ligand 23 0.298011
AURKC aurora kinase C 0.297651
TIMP1 TIMP metallopeptidase inhibitor 1 0.296931
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.294053
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.294053
IGLV9-49 immunoglobulin lambda variable 9-49 0.291898
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.28831
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.284371
C5AR1 complement component 5a receptor 1 0.284371
KMT2A lysine (K)-specific methyltransferase 2A 0.281868
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.281868
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.28151
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.276514
C6ORF25 chromosome 6 open reading frame 25 0.274021
STAG2 stromal antigen 2 0.271174
TLR2 toll-like receptor 2 0.268332
CYTIP cytohesin 1 interacting protein 0.266203
TCEA1 transcription elongation factor A (SII), 1 0.26514
TLR4 toll-like receptor 4 0.263368
GUSB glucuronidase, beta 0.261245
OCM2 oncomodulin 2 0.256652
ADSL adenylosuccinate lyase 0.254888
ICA1 islet cell autoantigen 1, 69kDa 0.254183
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.253479
PKP2 plakophilin 2 0.248554
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.246448
BAG6 BCL2-associated athanogene 6 0.245747
ALPPL2 alkaline phosphatase, placental-like 2 0.245396
ALPP alkaline phosphatase, placental 0.245046
SOCS5 suppressor of cytokine signaling 5 0.245046
KARS lysyl-tRNA synthetase 0.244345
ALPL alkaline phosphatase, liver/bone/kidney 0.244345
OCM oncomodulin 0.239799
NPB neuropeptide B 0.235616
KAT8 K(lysine) acetyltransferase 8 0.233878
TSN translin 0.23353
PF4 platelet factor 4 0.232489
SELE selectin E 0.231448
FUT2 fucosyltransferase 2 (secretor status included) 0.225917
GH2 growth hormone 2 0.224884
PHF12 PHD finger protein 12 0.224196
ATOH1 atonal homolog 1 (Drosophila) 0.215992
ADORA2B adenosine A2b receptor 0.215314
MOGS mannosyl-oligosaccharide glucosidase 0.211261
IARS isoleucyl-tRNA synthetase 0.210589
RNH1 ribonuclease/angiogenin inhibitor 1 0.210253
C1S complement component 1, s subcomponent 0.205254
HTRA3 HtrA serine peptidase 3 0.202946
IFI30 interferon, gamma-inducible protein 30 0.201635
IGLV3-10 immunoglobulin lambda variable 3-10 0.201308
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.197742
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.195183
RAET1E retinoic acid early transcript 1E 0.193915
SEBOX SEBOX homeobox 0.192971
ODC1 ornithine decarboxylase 1 0.192971
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.191408
PNMA1 paraneoplastic Ma antigen 1 0.188938
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.185612
HTRA1 HtrA serine peptidase 1 0.185612
HCAR2 hydroxycarboxylic acid receptor 2 0.184128
IL1B interleukin 1, beta 0.183541
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.180652
RGMB repulsive guidance molecule family member b 0.17952
FTL ferritin, light polypeptide 0.175679
FTH1 ferritin, heavy polypeptide 1 0.175411
GLB1 galactosidase, beta 1 0.175146
CFP complement factor properdin 0.174881
CD99 CD99 molecule 0.173314
ALOX15 arachidonate 15-lipoxygenase 0.173314
RAD23B RAD23 homolog B (S. cerevisiae) 0.173057
FBL fibrillarin 0.169812
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.169812
S100A11 S100 calcium binding protein A11 0.165435
TRIM21 tripartite motif containing 21 0.162908
ATG4C autophagy related 4C, cysteine peptidase 0.160574
HM13 histocompatibility (minor) 13 0.160387
MED28 mediator complex subunit 28 0.159302
HLA-E major histocompatibility complex, class I, E 0.158951
EVC Ellis van Creveld protein 0.158434
KIF21A kinesin family member 21A 0.157765
HN1 hematological and neurological expressed 1 0.145553
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.145428
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.144822
NAAA N-acylethanolamine acid amidase 0.143124
PNP purine nucleoside phosphorylase 0.142055
PRSS21 protease, serine, 21 (testisin) 0.141919
LPO lactoperoxidase 0.141211
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.139457
IVL involucrin 0.138453
GLUL glutamate-ammonia ligase 0.138348
THBD thrombomodulin 0.136581
CSF1R colony stimulating factor 1 receptor 0.136442
ELOVL6 ELOVL fatty acid elongase 6 0.136327
POMC proopiomelanocortin 0.136063
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.135764
KRT83 keratin 83, type II 0.135466
ZNF77 zinc finger protein 77 0.135452
SCG5 secretogranin V 0.135423
ADGRV1 adhesion G protein-coupled receptor V1 0.135277
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 0.134885
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.134745
TXNRD1 thioredoxin reductase 1 0.13373
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.132844
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.131695
PTH1R parathyroid hormone 1 receptor 0.13132
CD5 CD5 molecule 0.130764
CFH complement factor H 0.130254
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.12951
KDR kinase insert domain receptor 0.128829
GPR162 G protein-coupled receptor 162 0.128687
WIF1 WNT inhibitory factor 1 0.128573
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.12843
MAPK8 mitogen-activated protein kinase 8 0.1284
ANXA5 annexin A5 0.128312
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.127927
AHR aryl hydrocarbon receptor 0.126991
RFXANK regulatory factor X-associated ankyrin-containing protein 0.126731
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.126397