endodeoxyribonuclease activity, producing 5'-phosphomonoesters Gene Set

Dataset	GO Molecular Function Annotations 2025
Category	structural or functional annotations
Type	molecular function
Description	Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. (Gene Ontology, GO_0016888)
External Link	http://amigo.geneontology.org/amigo/term/GO:0016888
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Genes

13 genes performing the endodeoxyribonuclease activity, producing 5'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol	Name
APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1
DICER1	dicer 1, ribonuclease type III
DNA2	DNA replication helicase/nuclease 2
DNASE1	deoxyribonuclease I
DNASE1L1	deoxyribonuclease I-like 1
DNASE1L2	deoxyribonuclease I-like 2
DNASE1L3	deoxyribonuclease I-like 3
ENDOV	endonuclease V
EXO1	exonuclease 1
FAN1	FANCD2/FANCI-associated nuclease 1
FEN1	flap structure-specific endonuclease 1
GEN1	GEN1 Holliday junction 5' flap endonuclease
SLX1A	SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)