endogenous depression Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system. (Human Disease Ontology, DOID_1595)
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Genes

86 genes co-occuring with the disease endogenous depression in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TRH thyrotropin-releasing hormone 1.91033
DISC1 disrupted in schizophrenia 1 1.47945
MAOA monoamine oxidase A 1.46012
PI4K2B phosphatidylinositol 4-kinase type 2 beta 1.32454
POMC proopiomelanocortin 1.29833
ZNF80 zinc finger protein 80 1.19834
CRH corticotropin releasing hormone 1.15198
RNF123 ring finger protein 123 1.08537
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 1.05261
ALG9 ALG9, alpha-1,2-mannosyltransferase 1.03998
PDCD2 programmed cell death 2 0.909376
PDE4B phosphodiesterase 4B, cAMP-specific 0.865502
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 0.850354
TSNAX translin-associated factor X 0.844621
CHRM2 cholinergic receptor, muscarinic 2 0.835198
COMT catechol-O-methyltransferase 0.835198
PRL prolactin 0.817155
AVPR1B arginine vasopressin receptor 1B 0.800744
FLNA filamin A, alpha 0.76431
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.763494
TOR1A torsin family 1, member A (torsin A) 0.719654
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.71925
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.71078
CRHBP corticotropin releasing hormone binding protein 0.701928
AHRR aryl-hydrocarbon receptor repressor 0.669936
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.660008
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.641039
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.638282
CORT cortistatin 0.596012
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.589779
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.553627
NDEL1 nudE neurodevelopment protein 1-like 1 0.550134
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.522659
TES testin LIM domain protein 0.519961
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.512648
GH1 growth hormone 1 0.491978
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.474119
NKX2-2 NK2 homeobox 2 0.465794
SGSH N-sulfoglucosamine sulfohydrolase 0.465416
SYNE1 spectrin repeat containing, nuclear envelope 1 0.453716
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.443171
BDNF brain-derived neurotrophic factor 0.441666
CCK cholecystokinin 0.434148
CLOCK clock circadian regulator 0.425514
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.414276
MGP matrix Gla protein 0.391885
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.391885
DNAH8 dynein, axonemal, heavy chain 8 0.383708
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.37555
ACHE acetylcholinesterase (Yt blood group) 0.364454
EPGN epithelial mitogen 0.345308
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.342739
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.339806
NPS neuropeptide S 0.325187
MAOB monoamine oxidase B 0.321545
EP300 E1A binding protein p300 0.318635
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.312102
EFS embryonal Fyn-associated substrate 0.300894
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.272597
PRSS21 protease, serine, 21 (testisin) 0.270108
GAST gastrin 0.261952
TKT transketolase 0.260538
LAX1 lymphocyte transmembrane adaptor 1 0.253127
DRD4 dopamine receptor D4 0.245396
BPI bactericidal/permeability-increasing protein 0.238054
NPY neuropeptide Y 0.237009
DRD3 dopamine receptor D3 0.21974
SOX10 SRY (sex determining region Y)-box 10 0.216332
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.196459
POLG polymerase (DNA directed), gamma 0.194865
CREBBP CREB binding protein 0.183248
INS insulin 0.17952
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.173314
DCXR dicarbonyl/L-xylulose reductase 0.168148
NTF3 neurotrophin 3 0.163938
CCL11 chemokine (C-C motif) ligand 11 0.162908
TPH1 tryptophan hydroxylase 1 0.160761
NRG1 neuregulin 1 0.145763
FOXP2 forkhead box P2 0.145195
FGD1 FYVE, RhoGEF and PH domain containing 1 0.144494
IDO1 indoleamine 2,3-dioxygenase 1 0.144324
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.14385
CCL5 chemokine (C-C motif) ligand 5 0.143708
PRRC2A proline-rich coiled-coil 2A 0.143475
NOS2 nitric oxide synthase 2, inducible 0.143016
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.143009