endolysosome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. (Gene Ontology, GO_0036019)
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Genes

189 proteins co-occuring with the endolysosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TPCN2 two pore segment channel 2 2.04667
TPCN1 two pore segment channel 1 1.95793
UNC93B1 unc-93 homolog B1 (C. elegans) 1.79045
TLR9 toll-like receptor 9 1.73561
TLR7 toll-like receptor 7 1.43331
LAMP1 lysosomal-associated membrane protein 1 1.36088
MCOLN1 mucolipin 1 1.33467
CTSE cathepsin E 1.27399
CTSS cathepsin S 1.26656
CNPY3 canopy FGF signaling regulator 3 1.12245
TLR3 toll-like receptor 3 1.08323
CTSD cathepsin D 1.0035
FIG4 FIG4 phosphoinositide 5-phosphatase 0.938795
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.884244
VAC14 Vac14 homolog (S. cerevisiae) 0.842401
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.83781
TLR8 toll-like receptor 8 0.81624
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.809359
MCOLN2 mucolipin 2 0.797436
TMEM106B transmembrane protein 106B 0.783241
CBLN2 cerebellin 2 precursor 0.783241
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.780497
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.762252
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.757253
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 0.754983
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.747285
HLA-B major histocompatibility complex, class I, B 0.736464
WNK2 WNK lysine deficient protein kinase 2 0.729284
M6PR mannose-6-phosphate receptor (cation dependent) 0.724812
CDKL3 cyclin-dependent kinase-like 3 0.715458
EEA1 early endosome antigen 1 0.712351
CTSL cathepsin L 0.697344
TLR1 toll-like receptor 1 0.681591
CBLN1 cerebellin 1 precursor 0.678978
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.67463
NPC1 Niemann-Pick disease, type C1 0.67463
TLR6 toll-like receptor 6 0.669858
CC2D1A coiled-coil and C2 domain containing 1A 0.66164
CTSB cathepsin B 0.66164
MARCH4 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase 0.65905
GPR143 G protein-coupled receptor 143 0.639289
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.636295
MYD88 myeloid differentiation primary response 88 0.628613
LRRK2 leucine-rich repeat kinase 2 0.628187
BST2 bone marrow stromal cell antigen 2 0.620104
TMEM127 transmembrane protein 127 0.581758
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.581758
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.580504
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.572994
GRN granulin 0.569664
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.559285
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) 0.540706
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.540706
KIF25 kinesin family member 25 0.533309
RAB29 RAB29, member RAS oncogene family 0.524294
UBXN6 UBX domain protein 6 0.523885
CD4 CD4 molecule 0.522659
IFI30 interferon, gamma-inducible protein 30 0.519798
CBLN4 cerebellin 4 precursor 0.506757
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.504724
CD1D CD1d molecule 0.499447
LY96 lymphocyte antigen 96 0.498231
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.497826
FLOT2 flotillin 2 0.497826
CSNK1A1 casein kinase 1, alpha 1 0.4958
TLR2 toll-like receptor 2 0.492966
MTMR2 myotubularin related protein 2 0.491348
TLR4 toll-like receptor 4 0.490944
CBLN3 cerebellin 3 precursor 0.490135
NEK4 NIMA-related kinase 4 0.490135
TBC1D15 TBC1 domain family, member 15 0.478038
CDX1 caudal type homeobox 1 0.471609
LAMP2 lysosomal-associated membrane protein 2 0.471609
DAPK2 death-associated protein kinase 2 0.463598
PRNP prion protein 0.463598
NPC2 Niemann-Pick disease, type C2 0.458803
SKAP2 src kinase associated phosphoprotein 2 0.449643
PARK2 parkin RBR E3 ubiquitin protein ligase 0.446465
CTSK cathepsin K 0.445672
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 0.444482
AHRR aryl-hydrocarbon receptor repressor 0.444085
IFITM3 interferon induced transmembrane protein 3 0.439333
NVL nuclear VCP-like 0.426318
FYCO1 FYVE and coiled-coil domain containing 1 0.410259
EGOT eosinophil granule ontogeny transcript (non-protein coding) 0.408699
TSG101 tumor susceptibility 101 0.408309
VTI1B vesicle transport through interaction with t-SNAREs 1B 0.404026
FCGRT Fc fragment of IgG, receptor, transporter, alpha 0.398975
IRGM immunity-related GTPase family, M 0.398587
SBF2 SET binding factor 2 0.396648
GBA glucosidase, beta, acid 0.386979
RNF115 ring finger protein 115 0.385051
RAB4B RAB4B, member RAS oncogene family 0.383509
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.382354
SCP2 sterol carrier protein 2 0.380045
YIPF1 Yip1 domain family, member 1 0.374666
IRF7 interferon regulatory factor 7 0.367006
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.364713
DNAH8 dynein, axonemal, heavy chain 8 0.358609
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 0.354802
MCOLN3 mucolipin 3 0.352901
ZFYVE26 zinc finger, FYVE domain containing 26 0.349863
CD209 CD209 molecule 0.348725
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase 0.346829
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 0.344935
HSPA4 heat shock 70kDa protein 4 0.343042
HIST1H3G histone cluster 1, H3g 0.343042
HIST1H3F histone cluster 1, H3f 0.343042
HIST1H3D histone cluster 1, H3d 0.343042
HIST1H3B histone cluster 1, H3b 0.343042
HIST1H3I histone cluster 1, H3i 0.343042
HIST1H3J histone cluster 1, H3j 0.343042
CRYBA1 crystallin, beta A1 0.338884
CD63 CD63 molecule 0.329461
SGMS1 sphingomyelin synthase 1 0.325327
CHMP4B charged multivesicular body protein 4B 0.319702
STAMBP STAM binding protein 0.310358
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.296601
PFN4 profilin family, member 4 0.29623
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 0.294007
KIF21A kinesin family member 21A 0.292897
NOTCH1 notch 1 0.291047
PANX2 pannexin 2 0.285507
PFN2 profilin 2 0.282558
SH3KBP1 SH3-domain kinase binding protein 1 0.282189
AGO2 argonaute RISC catalytic component 2 0.281085
TF transferrin 0.281085
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.279612
GPR55 G protein-coupled receptor 55 0.277774
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 0.277038
RAB5C RAB5C, member RAS oncogene family 0.274468
PDCD6IP programmed cell death 6 interacting protein 0.274101
SNX6 sorting nexin 6 0.273734
FURIN furin (paired basic amino acid cleaving enzyme) 0.273367
UBE2N ubiquitin-conjugating enzyme E2N 0.269701
TICAM1 toll-like receptor adaptor molecule 1 0.267139
HIST1H3E histone cluster 1, H3e 0.267139
PFN1 profilin 1 0.266408
HIST1H3H histone cluster 1, H3h 0.266408
HIST1H3C histone cluster 1, H3c 0.266408
COMMD1 copper metabolism (Murr1) domain containing 1 0.265311
MRC1 mannose receptor, C type 1 0.260931
GRID2 glutamate receptor, ionotropic, delta 2 0.251476
RHOB ras homolog family member B 0.250026
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 0.248578
PI3 peptidase inhibitor 3, skin-derived 0.246407
PPP1R8 protein phosphatase 1, regulatory subunit 8 0.246046
MTM1 myotubularin 1 0.243879
HIST1H3A histone cluster 1, H3a 0.241716
UMPS uridine monophosphate synthetase 0.236324
HMGB1 high mobility group box 1 0.234533
EGFR epidermal growth factor receptor 0.234174
TPD52 tumor protein D52 0.233459
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 0.228819
CD86 CD86 molecule 0.227041
CD164 CD164 molecule, sialomucin 0.223497
PSAP prosaposin 0.220321
RAB7A RAB7A, member RAS oncogene family 0.218212
CTSV cathepsin V 0.211933
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.200999
PPT1 palmitoyl-protein thioesterase 1 0.199993
CPD carboxypeptidase D 0.19733
ARF6 ADP-ribosylation factor 6 0.196339
BECN1 beclin 1, autophagy related 0.194045
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.191777
CHM choroideremia (Rab escort protein 1) 0.188905
NSF N-ethylmaleimide-sensitive factor 0.187333
PRDM1 PR domain containing 1, with ZNF domain 0.186087
CST7 cystatin F (leukocystatin) 0.185469
IL1B interleukin 1, beta 0.185469
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.18516
PCDH11Y protocadherin 11 Y-linked 0.178011
PTPRA protein tyrosine phosphatase, receptor type, A 0.175745
APOL1 apolipoprotein L, 1 0.174911
KIF20A kinesin family member 20A 0.173543
PCDH11X protocadherin 11 X-linked 0.172201
PTPRB protein tyrosine phosphatase, receptor type, B 0.170371
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.167366
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.164542
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.164089
YBX3 Y box binding protein 3 0.1632
GRAP2 GRB2-related adaptor protein 2 0.160254
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) 0.159658
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.159658
CD38 CD38 molecule 0.159074
MON1A MON1 secretory trafficking family member A 0.158692
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.158502
PCBP1 poly(rC) binding protein 1 0.158129
CTSZ cathepsin Z 0.157039