endonuclease activity Gene Set

Dataset GO Molecular Function Annotations 2025
Category structural or functional annotations
Type molecular function
Description Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. (Gene Ontology, GO_0004519)
External Link http://amigo.geneontology.org/amigo/term/GO:0004519
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Genes

60 genes performing the endonuclease activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol Name
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
AGO3 argonaute RISC catalytic component 3
AGO4 argonaute RISC catalytic component 4
ANG angiogenin, ribonuclease, RNase A family, 5
ANKLE1 ankyrin repeat and LEM domain containing 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLF aprataxin and PNKP like factor
BIVM basic, immunoglobulin-like variable motif containing
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa
DCLRE1C DNA cross-link repair 1C
DICER1 dicer 1, ribonuclease type III
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
ELAC2 elaC ribonuclease Z 2
ENDOG endonuclease G
ENDOU endonuclease, polyU-specific
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERN1 endoplasmic reticulum to nucleus signaling 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FEN1 flap structure-specific endonuclease 1
INTS11 integrator complex subunit 11
KHNYN KH and NYN domain containing
LACTB2 lactamase, beta 2
MBD4 methyl-CpG binding domain protein 4
MBLAC1 metallo-beta-lactamase domain containing 1
MRE11 MRE11 homolog, double strand break repair nuclease
MUS81 MUS81 structure-specific endonuclease subunit
N4BP2 NEDD4 binding protein 2
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
NTHL1 nth endonuclease III-like 1 (E. coli)
NYNRIN NYN domain and retroviral integrase containing
OGG1 8-oxoguanine DNA glycosylase
PIWIL1 piwi-like RNA-mediated gene silencing 1
PIWIL2 piwi-like RNA-mediated gene silencing 2
PIWIL3 piwi-like RNA-mediated gene silencing 3
PIWIL4 piwi-like RNA-mediated gene silencing 4
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNKP polynucleotide kinase 3'-phosphatase
RAG1 recombination activating gene 1
RCL1 RNA terminal phosphate cyclase-like 1
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RNASEK ribonuclease, RNase K
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNASET2 ribonuclease T2
RPS3 ribosomal protein S3
SETMAR SET domain and mariner transposase fusion gene
SLFN13 schlafen family member 13
SLFN14 schlafen family member 14
SMG6 SMG6 nonsense mediated mRNA decay factor
SND1 staphylococcal nuclease and tudor domain containing 1
TSNAX translin-associated factor X
YBEY ybeY metallopeptidase (putative)
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H12B zinc finger CCCH-type containing 12B
ZC3H12C zinc finger CCCH-type containing 12C
ZC3H12D zinc finger CCCH-type containing 12D
ZRANB3 zinc finger, RAN-binding domain containing 3