endopeptidase activity Gene Set

Dataset GO Molecular Function Annotations 2015
Category structural or functional annotations
Type molecular function
Description Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. (Gene Ontology, GO_0004175)
External Link http://amigo.geneontology.org/amigo/term/GO:0004175
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Genes

411 genes performing the endopeptidase activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACR acrosin
ADAM10 ADAM metallopeptidase domain 10
ADAM11 ADAM metallopeptidase domain 11
ADAM12 ADAM metallopeptidase domain 12
ADAM15 ADAM metallopeptidase domain 15
ADAM17 ADAM metallopeptidase domain 17
ADAM18 ADAM metallopeptidase domain 18
ADAM19 ADAM metallopeptidase domain 19
ADAM2 ADAM metallopeptidase domain 2
ADAM20 ADAM metallopeptidase domain 20
ADAM21 ADAM metallopeptidase domain 21
ADAM22 ADAM metallopeptidase domain 22
ADAM23 ADAM metallopeptidase domain 23
ADAM28 ADAM metallopeptidase domain 28
ADAM29 ADAM metallopeptidase domain 29
ADAM30 ADAM metallopeptidase domain 30
ADAM32 ADAM metallopeptidase domain 32
ADAM33 ADAM metallopeptidase domain 33
ADAM7 ADAM metallopeptidase domain 7
ADAM8 ADAM metallopeptidase domain 8
ADAM9 ADAM metallopeptidase domain 9
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADAMTSL2 ADAMTS-like 2
ADAMTSL4 ADAMTS-like 4
ADAMTSL5 ADAMTS-like 5
ADGB androglobin
AFG3L2 AFG3-like AAA ATPase 2
APEH acylaminoacyl-peptide hydrolase
APH1A APH1A gamma secretase subunit
ASPRV1 aspartic peptidase, retroviral-like 1
ASTL astacin-like metallo-endopeptidase (M12 family)
ATG4A autophagy related 4A, cysteine peptidase
ATG4B autophagy related 4B, cysteine peptidase
ATG4C autophagy related 4C, cysteine peptidase
ATG4D autophagy related 4D, cysteine peptidase
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
AZU1 azurocidin 1
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BLMH bleomycin hydrolase
BMP1 bone morphogenetic protein 1
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C2 complement component 2
CAPN1 calpain 1, (mu/I) large subunit
CAPN10 calpain 10
CAPN11 calpain 11
CAPN12 calpain 12
CAPN13 calpain 13
CAPN14 calpain 14
CAPN15 calpain 15
CAPN2 calpain 2, (m/II) large subunit
CAPN3 calpain 3, (p94)
CAPN5 calpain 5
CAPN6 calpain 6
CAPN7 calpain 7
CAPN8 calpain 8
CAPN9 calpain 9
CAPNS1 calpain, small subunit 1
CAPNS2 calpain, small subunit 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD46 CD46 molecule, complement regulatory protein
CELA1 chymotrypsin-like elastase family, member 1
CELA2A chymotrypsin-like elastase family, member 2A
CELA2B chymotrypsin-like elastase family, member 2B
CELA3A chymotrypsin-like elastase family, member 3A
CELA3B chymotrypsin-like elastase family, member 3B
CFB complement factor B
CFD complement factor D (adipsin)
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CLC Charcot-Leyden crystal galectin
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CMA1 chymase 1, mast cell
CORIN corin, serine peptidase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTRB2 chymotrypsinogen B2
CTRC chymotrypsin C (caldecrin)
CTRL chymotrypsin-like
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSE cathepsin E
CTSF cathepsin F
CTSG cathepsin G
CTSH cathepsin H
CTSK cathepsin K
CTSL cathepsin L
CTSO cathepsin O
CTSS cathepsin S
CTSV cathepsin V
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae)
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae)
DPP4 dipeptidyl-peptidase 4
ECE1 endothelin converting enzyme 1
ECE2 endothelin converting enzyme 2
ECEL1 endothelin converting enzyme-like 1
ELANE elastase, neutrophil expressed
F10 coagulation factor X
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FAP fibroblast activation protein, alpha
FURIN furin (paired basic amino acid cleaving enzyme)
GCA grancalcin, EF-hand calcium binding protein
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMK granzyme K (granzyme 3; tryptase II)
GZMM granzyme M (lymphocyte met-ase 1)
HABP2 hyaluronan binding protein 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HGFAC HGF activator
HM13 histocompatibility (minor) 13
HPN hepsin
HTRA1 HtrA serine peptidase 1
HTRA2 HtrA serine peptidase 2
HTRA3 HtrA serine peptidase 3
HTRA4 HtrA serine peptidase 4
IDE insulin-degrading enzyme
KEL Kell blood group, metallo-endopeptidase
KLK1 kallikrein 1
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK12 kallikrein-related peptidase 12
KLK13 kallikrein-related peptidase 13
KLK14 kallikrein-related peptidase 14
KLK15 kallikrein-related peptidase 15
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KLK4 kallikrein-related peptidase 4
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
KLK9 kallikrein-related peptidase 9
KLKB1 kallikrein B, plasma (Fletcher factor) 1
LGMN legumain
LMLN leishmanolysin-like (metallopeptidase M8 family)
LONP1 lon peptidase 1, mitochondrial
LONP2 lon peptidase 2, peroxisomal
LTF lactotransferrin
MALT1 MALT1 paracaspase
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MASP2 mannan-binding lectin serine peptidase 2
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEP1A meprin A, alpha (PABA peptide hydrolase)
MEP1B meprin A, beta
MIPEP mitochondrial intermediate peptidase
MME membrane metallo-endopeptidase
MMEL1 membrane metallo-endopeptidase-like 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP19 matrix metallopeptidase 19
MMP2 matrix metallopeptidase 2
MMP20 matrix metallopeptidase 20
MMP21 matrix metallopeptidase 21
MMP23B matrix metallopeptidase 23B
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MMP25 matrix metallopeptidase 25
MMP26 matrix metallopeptidase 26
MMP27 matrix metallopeptidase 27
MMP28 matrix metallopeptidase 28
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MST1 macrophage stimulating 1
MST1L macrophage stimulating 1-like
NAPSA napsin A aspartic peptidase
NCSTN nicastrin
NLN neurolysin (metallopeptidase M3 family)
NRD1 nardilysin (N-arginine dibasic convertase)
NRIP2 nuclear receptor interacting protein 2
NRIP3 nuclear receptor interacting protein 3
OMA1 OMA1 zinc metallopeptidase
OVCH1 ovochymase 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PAPLN papilin, proteoglycan-like sulfated glycoprotein
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARL presenilin associated, rhomboid-like
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PCSK4 proprotein convertase subtilisin/kexin type 4
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PCSK9 proprotein convertase subtilisin/kexin type 9
PDCD6 programmed cell death 6
PDIA3 protein disulfide isomerase family A, member 3
PEF1 penta-EF-hand domain containing 1
PGA4 pepsinogen 4, group I (pepsinogen A)
PGA5 pepsinogen 5, group I (pepsinogen A)
PGC progastricsin (pepsinogen C)
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGK phosphatidylinositol glycan anchor biosynthesis, class K
PIP prolactin-induced protein
PITRM1 pitrilysin metallopeptidase 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLG plasminogen
PMPCA peptidase (mitochondrial processing) alpha
PMPCB peptidase (mitochondrial processing) beta
PREP prolyl endopeptidase
PREPL prolyl endopeptidase-like
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRSS1 protease, serine, 1 (trypsin 1)
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS21 protease, serine, 21 (testisin)
PRSS22 protease, serine, 22
PRSS27 protease, serine 27
PRSS3 protease, serine, 3
PRSS33 protease, serine, 33
PRSS36 protease, serine, 36
PRSS37 protease, serine, 37
PRSS38 protease, serine, 38
PRSS41 protease, serine, 41
PRSS42 protease, serine, 42
PRSS45 protease, serine, 45
PRSS46 protease, serine, 46
PRSS48 protease, serine, 48
PRSS50 protease, serine, 50
PRSS53 protease, serine, 53
PRSS54 protease, serine, 54
PRSS55 protease, serine, 55
PRSS56 protease, serine, 56
PRSS57 protease, serine, 57
PRSS58 protease, serine, 58
PRSS8 protease, serine, 8
PRTN3 proteinase 3
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RCE1 Ras converting CAAX endopeptidase 1
REN renin
RHBDD1 rhomboid domain containing 1
RHBDD2 rhomboid domain containing 2
RHBDD3 rhomboid domain containing 3
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RHBDL2 rhomboid, veinlet-like 2 (Drosophila)
RHBDL3 rhomboid, veinlet-like 3 (Drosophila)
SENP1 SUMO1/sentrin specific peptidase 1
SFRP1 secreted frizzled-related protein 1
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPPL2A signal peptide peptidase like 2A
SPPL2B signal peptide peptidase like 2B
SPPL2C signal peptide peptidase like 2C
SPPL3 signal peptide peptidase like 3
SRI sorcin
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TASP1 taspase, threonine aspartase, 1
THOP1 thimet oligopeptidase 1
THSD4 thrombospondin, type I, domain containing 4
TINAG tubulointerstitial nephritis antigen
TLL1 tolloid-like 1
TLL2 tolloid-like 2
TMEM59 transmembrane protein 59
TMPRSS11A transmembrane protease, serine 11A
TMPRSS11B transmembrane protease, serine 11B
TMPRSS11D transmembrane protease, serine 11D
TMPRSS11E transmembrane protease, serine 11E
TMPRSS11F transmembrane protease, serine 11F
TMPRSS12 transmembrane (C-terminal) protease, serine 12
TMPRSS13 transmembrane protease, serine 13
TMPRSS15 transmembrane protease, serine 15
TMPRSS2 transmembrane protease, serine 2
TMPRSS3 transmembrane protease, serine 3
TMPRSS4 transmembrane protease, serine 4
TMPRSS5 transmembrane protease, serine 5
TMPRSS6 transmembrane protease, serine 6
TMPRSS7 transmembrane protease, serine 7
TMPRSS9 transmembrane protease, serine 9
TPP1 tripeptidyl peptidase I
TPP2 tripeptidyl peptidase II
TPSAB1 tryptase alpha/beta 1
TPSD1 tryptase delta 1
TPSG1 tryptase gamma 1
TRABD2A TraB domain containing 2A
TRABD2B TraB domain containing 2B
TRAPPC12 trafficking protein particle complex 12
TYSND1 trypsin domain containing 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRC2 ubiquinol-cytochrome c reductase core protein II
USP1 ubiquitin specific peptidase 1
USP10 ubiquitin specific peptidase 10
USP11 ubiquitin specific peptidase 11
USP12 ubiquitin specific peptidase 12
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP15 ubiquitin specific peptidase 15
USP16 ubiquitin specific peptidase 16
USP17L10 ubiquitin specific peptidase 17-like family member 10
USP17L11 ubiquitin specific peptidase 17-like family member 11
USP17L12 ubiquitin specific peptidase 17-like family member 12
USP17L13 ubiquitin specific peptidase 17-like family member 13
USP17L17 ubiquitin specific peptidase 17-like family member 17
USP17L18 ubiquitin specific peptidase 17-like family member 18
USP17L19 ubiquitin specific peptidase 17-like family member 19
USP17L2 ubiquitin specific peptidase 17-like family member 2
USP17L20 ubiquitin specific peptidase 17-like family member 20
USP17L21 ubiquitin specific peptidase 17-like family member 21
USP17L22 ubiquitin specific peptidase 17-like family member 22
USP17L5 ubiquitin specific peptidase 17-like family member 5
USP18 ubiquitin specific peptidase 18
USP19 ubiquitin specific peptidase 19
USP2 ubiquitin specific peptidase 2
USP20 ubiquitin specific peptidase 20
USP21 ubiquitin specific peptidase 21
USP22 ubiquitin specific peptidase 22
USP24 ubiquitin specific peptidase 24
USP25 ubiquitin specific peptidase 25
USP26 ubiquitin specific peptidase 26
USP28 ubiquitin specific peptidase 28
USP29 ubiquitin specific peptidase 29
USP3 ubiquitin specific peptidase 3
USP30 ubiquitin specific peptidase 30
USP31 ubiquitin specific peptidase 31
USP32 ubiquitin specific peptidase 32
USP33 ubiquitin specific peptidase 33
USP34 ubiquitin specific peptidase 34
USP35 ubiquitin specific peptidase 35
USP36 ubiquitin specific peptidase 36
USP37 ubiquitin specific peptidase 37
USP38 ubiquitin specific peptidase 38
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP40 ubiquitin specific peptidase 40
USP42 ubiquitin specific peptidase 42
USP43 ubiquitin specific peptidase 43
USP44 ubiquitin specific peptidase 44
USP45 ubiquitin specific peptidase 45
USP47 ubiquitin specific peptidase 47
USP48 ubiquitin specific peptidase 48
USP49 ubiquitin specific peptidase 49
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP51 ubiquitin specific peptidase 51
USP6 ubiquitin specific peptidase 6
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP8 ubiquitin specific peptidase 8
USP9X ubiquitin specific peptidase 9, X-linked
USP9Y ubiquitin specific peptidase 9, Y-linked
XRCC6BP1 XRCC6 binding protein 1
YBEY ybeY metallopeptidase (putative)
YME1L1 YME1-like 1 ATPase
ZMPSTE24 zinc metallopeptidase STE24