endopeptidase activity Gene Set

Dataset GO Molecular Function Annotations 2023
Category structural or functional annotations
Type biological process
Description Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. (Gene Ontology, GO_0004175)
External Link http://amigo.geneontology.org/amigo/term/GO:0004175
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Genes

336 genes performing the endopeptidase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACR acrosin
ADAM10 ADAM metallopeptidase domain 10
ADAM11 ADAM metallopeptidase domain 11
ADAM12 ADAM metallopeptidase domain 12
ADAM15 ADAM metallopeptidase domain 15
ADAM17 ADAM metallopeptidase domain 17
ADAM19 ADAM metallopeptidase domain 19
ADAM2 ADAM metallopeptidase domain 2
ADAM20 ADAM metallopeptidase domain 20
ADAM21 ADAM metallopeptidase domain 21
ADAM22 ADAM metallopeptidase domain 22
ADAM23 ADAM metallopeptidase domain 23
ADAM28 ADAM metallopeptidase domain 28
ADAM29 ADAM metallopeptidase domain 29
ADAM30 ADAM metallopeptidase domain 30
ADAM32 ADAM metallopeptidase domain 32
ADAM33 ADAM metallopeptidase domain 33
ADAM7 ADAM metallopeptidase domain 7
ADAM8 ADAM metallopeptidase domain 8
ADAM9 ADAM metallopeptidase domain 9
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADAMTSL2 ADAMTS-like 2
ADGRG6 adhesion G protein-coupled receptor G6
AFG3L2 AFG3-like AAA ATPase 2
APEH acylaminoacyl-peptide hydrolase
ASPRV1 aspartic peptidase, retroviral-like 1
ASTL astacin-like metallo-endopeptidase (M12 family)
ATG4B autophagy related 4B, cysteine peptidase
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BMP1 bone morphogenetic protein 1
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
CAPN5 calpain 5
CAPN7 calpain 7
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD5L CD5 molecule-like
CEL carboxyl ester lipase
CELA1 chymotrypsin-like elastase family, member 1
CELA2A chymotrypsin-like elastase family, member 2A
CELA2B chymotrypsin-like elastase family, member 2B
CELA3A chymotrypsin-like elastase family, member 3A
CELA3B chymotrypsin-like elastase family, member 3B
CFB complement factor B
CFD complement factor D (adipsin)
CLCA1 chloride channel accessory 1
CLCA2 chloride channel accessory 2
CLCA3P chloride channel accessory 3, pseudogene
CLCA4 chloride channel accessory 4
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CMA1 chymase 1, mast cell
CNTN1 contactin 1
CORIN corin, serine peptidase
CPNE1 copine I
CTRB1 chymotrypsinogen B1
CTRB2 chymotrypsinogen B2
CTRC chymotrypsin C (caldecrin)
CTRL chymotrypsin-like
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSE cathepsin E
CTSF cathepsin F
CTSG cathepsin G
CTSH cathepsin H
CTSK cathepsin K
CTSL cathepsin L
CTSS cathepsin S
CTSV cathepsin V
CTSW cathepsin W
CTSZ cathepsin Z
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae)
DPP4 dipeptidyl-peptidase 4
ECE1 endothelin converting enzyme 1
ECE2 endothelin converting enzyme 2
ECEL1 endothelin converting enzyme-like 1
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough
ELANE elastase, neutrophil expressed
ERAP1 endoplasmic reticulum aminopeptidase 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
F10 coagulation factor X
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F9 coagulation factor IX
FURIN furin (paired basic amino acid cleaving enzyme)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMK granzyme K (granzyme 3; tryptase II)
GZMM granzyme M (lymphocyte met-ase 1)
HABP2 hyaluronan binding protein 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HGFAC HGF activator
HP haptoglobin
HPN hepsin
HPR haptoglobin-related protein
HTRA2 HtrA serine peptidase 2
HTRA4 HtrA serine peptidase 4
IDE insulin-degrading enzyme
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
JMJD7 jumonji domain containing 7
KDM8 lysine (K)-specific demethylase 8
KEL Kell blood group, metallo-endopeptidase
KLK1 kallikrein 1
KLK12 kallikrein-related peptidase 12
KLK13 kallikrein-related peptidase 13
KLK14 kallikrein-related peptidase 14
KLK15 kallikrein-related peptidase 15
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
KLK9 kallikrein-related peptidase 9
LGMN legumain
LPA lipoprotein, Lp(a)
MALT1 MALT1 paracaspase
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MASP2 mannan-binding lectin serine peptidase 2
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEP1A meprin A, alpha (PABA peptide hydrolase)
MEP1B meprin A, beta
MIPEP mitochondrial intermediate peptidase
MME membrane metallo-endopeptidase
MMEL1 membrane metallo-endopeptidase-like 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP19 matrix metallopeptidase 19
MMP2 matrix metallopeptidase 2
MMP20 matrix metallopeptidase 20
MMP23A matrix metallopeptidase 23A (pseudogene)
MMP23B matrix metallopeptidase 23B
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MMP26 matrix metallopeptidase 26
MMP27 matrix metallopeptidase 27
MMP28 matrix metallopeptidase 28
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MST1 macrophage stimulating 1
MST1L macrophage stimulating 1-like
NAPSA napsin A aspartic peptidase
NLN neurolysin (metallopeptidase M3 family)
NRDC nardilysin convertase
OMA1 OMA1 zinc metallopeptidase
OVCH2 ovochymase 2 (gene/pseudogene)
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PARL presenilin associated, rhomboid-like
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PCSK4 proprotein convertase subtilisin/kexin type 4
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PCSK9 proprotein convertase subtilisin/kexin type 9
PDIA3 protein disulfide isomerase family A, member 3
PGA3 pepsinogen 3, group I (pepsinogen A)
PGA4 pepsinogen 4, group I (pepsinogen A)
PGA5 pepsinogen 5, group I (pepsinogen A)
PGC progastricsin (pepsinogen C)
PHEX phosphate regulating endopeptidase homolog, X-linked
PIDD1 p53-induced death domain protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP prolactin-induced protein
PITRM1 pitrilysin metallopeptidase 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLG plasminogen
PMPCB peptidase (mitochondrial processing) beta
PREP prolyl endopeptidase
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRSS1 protease, serine, 1 (trypsin 1)
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS21 protease, serine, 21 (testisin)
PRSS22 protease, serine, 22
PRSS29P protease, serine, 29, pseudogene
PRSS3 protease, serine, 3
PRSS33 protease, serine, 33
PRSS36 protease, serine, 36
PRSS38 protease, serine, 38
PRSS3P2 protease, serine, 3 pseudogene 2
PRSS42 protease, serine, 42
PRSS45 protease, serine, 45
PRSS47 protease, serine, 47
PRSS48 protease, serine, 48
PRSS50 protease, serine, 50
PRSS53 protease, serine, 53
PRSS54 protease, serine, 54
PRSS56 protease, serine, 56
PRTN3 proteinase 3
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RCE1 Ras converting CAAX endopeptidase 1
REN renin
RHBDD1 rhomboid domain containing 1
RHBDD3 rhomboid domain containing 3
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RHBDL2 rhomboid, veinlet-like 2 (Drosophila)
RHBDL3 rhomboid, veinlet-like 3 (Drosophila)
SEC11A SEC11 homolog A (S. cerevisiae)
SEC11C SEC11 homolog C (S. cerevisiae)
SENP1 SUMO1/sentrin specific peptidase 1
SFRP1 secreted frizzled-related protein 1
SHH sonic hedgehog
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPRTN SprT-like N-terminal domain
TASP1 taspase, threonine aspartase, 1
THOP1 thimet oligopeptidase 1
TINAG tubulointerstitial nephritis antigen
TLL1 tolloid-like 1
TLL2 tolloid-like 2
TMPRSS13 transmembrane protease, serine 13
TMPRSS2 transmembrane protease, serine 2
TMPRSS4 transmembrane protease, serine 4
TMPRSS6 transmembrane protease, serine 6
TPP1 tripeptidyl peptidase I
TPP2 tripeptidyl peptidase II
TPSAB1 tryptase alpha/beta 1
TPSD1 tryptase delta 1
TPSG1 tryptase gamma 1
TRABD2A TraB domain containing 2A
TRABD2B TraB domain containing 2B
TYSND1 trypsin domain containing 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP1 ubiquitin specific peptidase 1
USP10 ubiquitin specific peptidase 10
USP11 ubiquitin specific peptidase 11
USP12P1 ubiquitin specific peptidase 12 pseudogene 1
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP15 ubiquitin specific peptidase 15
USP16 ubiquitin specific peptidase 16
USP17L1 ubiquitin specific peptidase 17-like family member 1
USP17L11 ubiquitin specific peptidase 17-like family member 11
USP17L12 ubiquitin specific peptidase 17-like family member 12
USP17L13 ubiquitin specific peptidase 17-like family member 13
USP17L15 ubiquitin specific peptidase 17-like family member 15
USP17L17 ubiquitin specific peptidase 17-like family member 17
USP17L18 ubiquitin specific peptidase 17-like family member 18
USP17L19 ubiquitin specific peptidase 17-like family member 19
USP17L2 ubiquitin specific peptidase 17-like family member 2
USP17L20 ubiquitin specific peptidase 17-like family member 20
USP17L21 ubiquitin specific peptidase 17-like family member 21
USP17L22 ubiquitin specific peptidase 17-like family member 22
USP17L24 ubiquitin specific peptidase 17-like family member 24
USP17L3 ubiquitin specific peptidase 17-like family member 3
USP17L4 ubiquitin specific peptidase 17-like family member 4
USP17L5 ubiquitin specific peptidase 17-like family member 5
USP17L6P ubiquitin specific peptidase 17-like family member 6, pseudogene
USP17L7 ubiquitin specific peptidase 17-like family member 7
USP17L8 ubiquitin specific peptidase 17-like family member 8
USP18 ubiquitin specific peptidase 18
USP2 ubiquitin specific peptidase 2
USP20 ubiquitin specific peptidase 20
USP24 ubiquitin specific peptidase 24
USP25 ubiquitin specific peptidase 25
USP26 ubiquitin specific peptidase 26
USP27X ubiquitin specific peptidase 27, X-linked
USP28 ubiquitin specific peptidase 28
USP29 ubiquitin specific peptidase 29
USP30 ubiquitin specific peptidase 30
USP33 ubiquitin specific peptidase 33
USP34 ubiquitin specific peptidase 34
USP35 ubiquitin specific peptidase 35
USP36 ubiquitin specific peptidase 36
USP37 ubiquitin specific peptidase 37
USP38 ubiquitin specific peptidase 38
USP40 ubiquitin specific peptidase 40
USP41 ubiquitin specific peptidase 41
USP42 ubiquitin specific peptidase 42
USP46 ubiquitin specific peptidase 46
USP47 ubiquitin specific peptidase 47
USP48 ubiquitin specific peptidase 48
USP49 ubiquitin specific peptidase 49
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP6 ubiquitin specific peptidase 6
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP8 ubiquitin specific peptidase 8
USP9X ubiquitin specific peptidase 9, X-linked
USP9Y ubiquitin specific peptidase 9, Y-linked
ZMPSTE24 zinc metallopeptidase STE24