endopeptidase inhibitor activity Gene Set

Dataset GO Molecular Function Annotations 2025
Category structural or functional annotations
Type molecular function
Description Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. (Gene Ontology, GO_0004866)
External Link http://amigo.geneontology.org/amigo/term/GO:0004866
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Genes

120 genes performing the endopeptidase inhibitor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol Name
A2M alpha-2-macroglobulin
AGXT alanine-glyoxylate aminotransferase
AHSG alpha-2-HS-glycoprotein
AMBP alpha-1-microglobulin/bikunin precursor
ANXA2 annexin A2
APLP2 amyloid beta (A4) precursor-like protein 2
APP amyloid beta (A4) precursor protein
BIN1 bridging integrator 1
BIRC6 baculoviral IAP repeat containing 6
BIRC7 baculoviral IAP repeat containing 7
BST2 bone marrow stromal cell antigen 2
CARD16 caspase recruitment domain family, member 16
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COPS2 COP9 signalosome subunit 2
CRB2 crumbs family member 2
CST1 cystatin SN
CST2 cystatin SA
CST3 cystatin C
CST4 cystatin S
CST5 cystatin D
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CSTB cystatin B (stefin B)
ERC2 ELKS/RAB6-interacting/CAST family member 2
FETUB fetuin B
FURIN furin (paired basic amino acid cleaving enzyme)
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBP2 guanylate binding protein 2, interferon-inducible
GBP5 guanylate binding protein 5
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KNG1 kininogen 1
LCN1 lipocalin 1
LPA lipoprotein, Lp(a)
LTF lactotransferrin
LXN latexin
MANSC4 MANSC domain containing 4
NGF nerve growth factor (beta polypeptide)
NLRP7 NLR family, pyrin domain containing 7
OPRPN opiorphin prepropeptide
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PI3 peptidase inhibitor 3, skin-derived
PRNP prion protein
PROS1 protein S (alpha)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTTG1 pituitary tumor-transforming 1
PZP pregnancy-zone protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RENBP renin binding protein
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SGPP2 sphingosine-1-phosphate phosphatase 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SMR3A submaxillary gland androgen regulated protein 3A
SMR3B submaxillary gland androgen regulated protein 3B
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPINK9 serine peptidase inhibitor, Kazal type 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
WFDC10A WAP four-disulfide core domain 10A
WFDC10B WAP four-disulfide core domain 10B
WFDC11 WAP four-disulfide core domain 11
WFDC12 WAP four-disulfide core domain 12
WFDC13 WAP four-disulfide core domain 13
WFDC2 WAP four-disulfide core domain 2
WFDC3 WAP four-disulfide core domain 3
WFDC5 WAP four-disulfide core domain 5
WFDC9 WAP four-disulfide core domain 9
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase