endothelium Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An epithelium of mesodermal origin composed of a single layer of thin flattened cells that lines internal body cavities. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000393)
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Genes

334 genes co-occuring with the biological term endothelium in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM15 ADAM metallopeptidase domain 15
ADAM17 ADAM metallopeptidase domain 17
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADGRE5 adhesion G protein-coupled receptor E5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX15 arachidonate 15-lipoxygenase
ANGPT2 angiopoietin 2
ANXA1 annexin A1
AOC3 amine oxidase, copper containing 3
APLN apelin
APP amyloid beta (A4) precursor protein
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
AQP10 aquaporin 10
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
AZU1 azurocidin 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2 B-cell CLL/lymphoma 2
BDKRB1 bradykinin receptor B1
BMP4 bone morphogenetic protein 4
BMPER BMP binding endothelial regulator
BST2 bone marrow stromal cell antigen 2
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCM2 cerebral cavernous malformation 2
CD14 CD14 molecule
CD248 CD248 molecule, endosialin
CD34 CD34 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CD93 CD93 molecule
CDH13 cadherin 13
CDH5 cadherin 5, type 2 (vascular endothelium)
CHGA chromogranin A
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHUK conserved helix-loop-helix ubiquitous kinase
CLDN5 claudin 5
CLEC4M C-type lectin domain family 4, member M
CMA1 chymase 1, mast cell
CNR2 cannabinoid receptor 2 (macrophage)
COLEC12 collectin sub-family member 12
CORT cortistatin
CREG1 cellular repressor of E1A-stimulated genes 1
CRP C-reactive protein, pentraxin-related
CTNND1 catenin (cadherin-associated protein), delta 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DICER1 dicer 1, ribonuclease type III
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLL4 delta-like 4 (Drosophila)
DNM2 dynamin 2
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
ECE1 endothelin converting enzyme 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EFNB2 ephrin-B2
ENG endoglin
EPAS1 endothelial PAS domain protein 1
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
ESM1 endothelial cell-specific molecule 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRB estrogen-related receptor beta
F11R F11 receptor
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FAM3A family with sequence similarity 3, member A
FAS Fas cell surface death receptor
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FGB fibrinogen beta chain
FGF2 fibroblast growth factor 2 (basic)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GCH1 GTP cyclohydrolase 1
GDF2 growth differentiation factor 2
GJA4 gap junction protein, alpha 4, 37kDa
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HOXD10 homeobox D10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPB2 heat shock 27kDa protein 2
ICAM1 intercellular adhesion molecule 1
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICOS inducible T-cell co-stimulator
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IGH immunoglobulin heavy locus
IL10 interleukin 10
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL27 interleukin 27
IL3 interleukin 3
IL31RA interleukin 31 receptor A
IL33 interleukin 33
IL4 interleukin 4
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ILK integrin-linked kinase
INHBA inhibin, beta A
INS insulin
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA9 integrin, alpha 9
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAM2 junctional adhesion molecule 2
JAM3 junctional adhesion molecule 3
KDR kinase insert domain receptor
KIF17 kinesin family member 17
KIFC1 kinesin family member C1
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLK1 kallikrein 1
KNG1 kininogen 1
KRIT1 KRIT1, ankyrin repeat containing
L1CAM L1 cell adhesion molecule
LAMA4 laminin, alpha 4
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
LGALS8 lectin, galactoside-binding, soluble, 8
LGALS9 lectin, galactoside-binding, soluble, 9
LIPG lipase, endothelial
LY96 lymphocyte antigen 96
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MCAM melanoma cell adhesion molecule
MDK midkine (neurite growth-promoting factor 2)
MEF2A myocyte enhancer factor 2A
MEOX2 mesenchyme homeobox 2
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR126 microRNA 126
MIR146A microRNA 146a
MIR21 microRNA 21
MIR29A microRNA 29a
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MVP major vault protein
NCF1 neutrophil cytosolic factor 1
NES nestin
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX4 NADPH oxidase 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPY neuropeptide Y
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRP1 neuropilin 1
NRP2 neuropilin 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OSM oncostatin M
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PANX1 pannexin 1
PARD3 par-3 family cell polarity regulator
PARP1 poly (ADP-ribose) polymerase 1
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPN podoplanin
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PNPLA2 patatin-like phospholipase domain containing 2
POU2F1 POU class 2 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCA protein kinase C, alpha
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PTEN phosphatase and tensin homolog
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTX3 pentraxin 3, long
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1B RAP1B, member of RAS oncogene family
RARB retinoic acid receptor, beta
RBP4 retinol binding protein 4, plasma
RETN resistin
RHOA ras homolog family member A
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S1PR2 sphingosine-1-phosphate receptor 2
S1PR5 sphingosine-1-phosphate receptor 5
SCARB1 scavenger receptor class B, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE1 signal peptide, CUB domain, EGF-like 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC4 syndecan 4
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHBG sex hormone-binding globulin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIGLEC10 sialic acid binding Ig-like lectin 10
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF2 sterol regulatory element binding transcription factor 2
STAB1 stabilin 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAL1 T-cell acute lymphocytic leukemia 1
TEAD4 TEA domain family member 4
TERT telomerase reverse transcriptase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBD thrombomodulin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TMIGD2 transmembrane and immunoglobulin domain containing 2
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TP53 tumor protein p53
TPST1 tyrosylprotein sulfotransferase 1
TPST2 tyrosylprotein sulfotransferase 2
TREML1 triggering receptor expressed on myeloid cells-like 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TTPA tocopherol (alpha) transfer protein
TXNRD1 thioredoxin reductase 1
TXNRD2 thioredoxin reductase 2
UTS2R urotensin 2 receptor
VASH1 vasohibin 1
VASH2 vasohibin 2
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
VLDLR very low density lipoprotein receptor
VSX1 visual system homeobox 1
VWF von Willebrand factor
WNT2 wingless-type MMTV integration site family member 2
WNT3A wingless-type MMTV integration site family, member 3A