enhanced behavioral response to addictive substance Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response (Mammalian Phenotype Ontology, MP_0009749)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009749
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Genes

39 gene mutations causing the enhanced behavioral response to addictive substance phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRL3 adhesion G protein-coupled receptor L3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CALCB calcitonin-related polypeptide beta
CCKBR cholecystokinin B receptor
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLOCK clock circadian regulator
CYFIP2 cytoplasmic FMR1 interacting protein 2
DLG4 discs, large homolog 4 (Drosophila)
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
FYN FYN proto-oncogene, Src family tyrosine kinase
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRK6 G protein-coupled receptor kinase 6
HOMER1 homer scaffolding protein 1
HOMER2 homer scaffolding protein 2
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IL6 interleukin 6
LMO4 LIM domain only 4
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NOS1 nitric oxide synthase 1 (neuronal)
NR4A2 nuclear receptor subfamily 4, group A, member 2
OPRM1 opioid receptor, mu 1
PER2 period circadian clock 2
POMC proopiomelanocortin
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCG protein kinase C, gamma
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
TAAR1 trace amine associated receptor 1
UNC79 unc-79 homolog (C. elegans)
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