enlarged myocardial fiber Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased size of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart (Mammalian Phenotype Ontology, MP_0004564)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004564
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33 gene mutations causing the enlarged myocardial fiber phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CSRP2 cysteine and glycine-rich protein 2
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
DNM1L dynamin 1-like
EPO erythropoietin
ESR2 estrogen receptor 2 (ER beta)
FOXM1 forkhead box M1
GATA5 GATA binding protein 5
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
KLF15 Kruppel-like factor 15
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMA4 laminin, alpha 4
LEP leptin
LTBP4 latent transforming growth factor beta binding protein 4
MYBPC3 myosin binding protein C, cardiac
MYH10 myosin, heavy chain 10, non-muscle
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYLK3 myosin light chain kinase 3
NEK6 NIMA-related kinase 6
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPARG peroxisome proliferator-activated receptor gamma
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
SIRT7 sirtuin 7
SOD2 superoxide dismutase 2, mitochondrial
SOS1 son of sevenless homolog 1 (Drosophila)
TTN titin
VAV2 vav 2 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
XIRP2 xin actin binding repeat containing 2