enoxacin-5251 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the enoxacin-5251 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
AKAP5 A kinase (PRKA) anchor protein 5
ANKLE2 ankyrin repeat and LEM domain containing 2
ANO1 anoctamin 1, calcium activated chloride channel
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
AQP7 aquaporin 7
ARHGAP4 Rho GTPase activating protein 4
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
C21ORF2 chromosome 21 open reading frame 2
C2ORF27A chromosome 2 open reading frame 27A
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CD58 CD58 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDK13 cyclin-dependent kinase 13
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHI3L2 chitinase 3-like 2
CLCA2 chloride channel accessory 2
CLTA clathrin, light chain A
CNTD2 cyclin N-terminal domain containing 2
COL14A1 collagen, type XIV, alpha 1
COL1A1 collagen, type I, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPM carboxypeptidase M
CRH corticotropin releasing hormone
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
DCSTAMP dendrocyte expressed seven transmembrane protein
DCTN1 dynactin 1
DGCR2 DiGeorge syndrome critical region gene 2
DHRS12 dehydrogenase/reductase (SDR family) member 12
DMRT1 doublesex and mab-3 related transcription factor 1
DMXL2 Dmx-like 2
EGR1 early growth response 1
EXOC7 exocyst complex component 7
F2RL2 coagulation factor II (thrombin) receptor-like 2
FBLN1 fibulin 1
FGF16 fibroblast growth factor 16
FHL1 four and a half LIM domains 1
FOXG1 forkhead box G1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GPR137 G protein-coupled receptor 137
GPR143 G protein-coupled receptor 143
GYPB glycophorin B (MNS blood group)
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HFE hemochromatosis
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IDI2-AS1 IDI2 antisense RNA 1
IL16 interleukin 16
IL1A interleukin 1, alpha
ING2 inhibitor of growth family, member 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JUN jun proto-oncogene
LAPTM5 lysosomal protein transmembrane 5
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MVB12B multivesicular body subunit 12B
NF1 neurofibromin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
ONECUT2 one cut homeobox 2
OXCT2 3-oxoacid CoA transferase 2
PARVA parvin, alpha
PCDH7 protocadherin 7
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLM polymerase (DNA directed), mu
PPT2 palmitoyl-protein thioesterase 2
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PWAR5 Prader Willi/Angelman region RNA 5
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAB6B RAB6B, member RAS oncogene family
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REEP2 receptor accessory protein 2
RND2 Rho family GTPase 2
RPL35A ribosomal protein L35a
SHOX2 short stature homeobox 2
SLAMF7 SLAM family member 7
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SNED1 sushi, nidogen and EGF-like domains 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TMLHE trimethyllysine hydroxylase, epsilon
TNS1 tensin 1
UPK3B uroplakin 3B
VN1R1 vomeronasal 1 receptor 1
WSB1 WD repeat and SOCS box containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF407 zinc finger protein 407
ZNF440 zinc finger protein 440
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACTL8 actin-like 8
ADAM15 ADAM metallopeptidase domain 15
ALS2CL ALS2 C-terminal like
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMC6 armadillo repeat containing 6
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BLNK B-cell linker
BMP15 bone morphogenetic protein 15
BPGM 2,3-bisphosphoglycerate mutase
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK4 calcium/calmodulin-dependent protein kinase IV
CDADC1 cytidine and dCMP deaminase domain containing 1
CDR2L cerebellar degeneration-related protein 2-like
CENPO centromere protein O
CERK ceramide kinase
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CLDN15 claudin 15
CLGN calmegin
CLSTN2 calsyntenin 2
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COPZ2 coatomer protein complex, subunit zeta 2
CORT cortistatin
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDAR ectodysplasin A receptor
EFNA3 ephrin-A3
ERCC5 excision repair cross-complementation group 5
FGL1 fibrinogen-like 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GAS2 growth arrest-specific 2
GID4 GID complex subunit 4
GMEB1 glucocorticoid modulatory element binding protein 1
GPR21 G protein-coupled receptor 21
GPR27 G protein-coupled receptor 27
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
INPP1 inositol polyphosphate-1-phosphatase
KIAA0754 KIAA0754
KRT8P12 keratin 8 pseudogene 12
LMNB1 lamin B1
LRRC37A2 leucine rich repeat containing 37, member A2
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MATK megakaryocyte-associated tyrosine kinase
MFSD12 major facilitator superfamily domain containing 12
MGC12488
MPI mannose phosphate isomerase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC3A mucin 3A, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPFFR1 neuropeptide FF receptor 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OSGIN1 oxidative stress induced growth inhibitor 1
OVOL1 ovo-like zinc finger 1
PCDHB13 protocadherin beta 13
PGR progesterone receptor
PGS1 phosphatidylglycerophosphate synthase 1
PLA2G10 phospholipase A2, group X
PLA2G3 phospholipase A2, group III
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PRSS16 protease, serine, 16 (thymus)
PRSS53 protease, serine, 53
PTPRU protein tyrosine phosphatase, receptor type, U
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RNF43 ring finger protein 43
RPGRIP1L RPGRIP1-like
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
STARD3 StAR-related lipid transfer (START) domain containing 3
STK16 serine/threonine kinase 16
STK25 serine/threonine kinase 25
STON1 stonin 1
STRA6 stimulated by retinoic acid 6
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCTA T-cell leukemia translocation altered
TCTN1 tectonic family member 1
TMEM120B transmembrane protein 120B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM36 tripartite motif containing 36
TUBG2 tubulin, gamma 2
USB1 U6 snRNA biogenesis 1
VPS9D1 VPS9 domain containing 1
ZIC3 Zic family member 3
ZNF324 zinc finger protein 324
ZNF639 zinc finger protein 639
ZNF816 zinc finger protein 816
ZNF862 zinc finger protein 862