eomes_23431145_e14dot5_neocortex_lof_mouse_gpl6246_gse43387 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43387
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Genes

343 genes differentially expressed following the eomes_23431145_e14dot5_neocortex_lof_mouse_gpl6246_gse43387 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
CHODL chondrolectin 0.181087
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.181057
OLIG3 oligodendrocyte transcription factor 3 0.180857
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 0.180688
RGMB repulsive guidance molecule family member b 0.180688
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.180626
CBLN2 cerebellin 2 precursor 0.180426
NRP2 neuropilin 2 0.180319
ASIC1 acid sensing (proton gated) ion channel 1 0.180227
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.180089
LMCD1 LIM and cysteine-rich domains 1 0.179721
ANGPT1 angiopoietin 1 0.179353
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.178955
ZNF521 zinc finger protein 521 0.178924
AFF2 AF4/FMR2 family, member 2 0.178328
CNTNAP5 contactin associated protein-like 5 0.17819
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.177363
TACR3 tachykinin receptor 3 0.177131
NOL4 nucleolar protein 4 0.176837
DCC DCC netrin 1 receptor 0.176189
NHLH1 nescient helix loop helix 1 0.175695
CSMD1 CUB and Sushi multiple domains 1 0.173119
NXPH4 neurexophilin 4 0.172404
ABHD2 abhydrolase domain containing 2 0.172203
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 0.172048
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.171443
FSTL5 follistatin-like 5 0.171397
PRUNE2 prune homolog 2 (Drosophila) 0.17016
ZEB1 zinc finger E-box binding homeobox 1 0.16935
NCAM2 neural cell adhesion molecule 2 0.169147
VAT1 vesicle amine transport 1 0.167697
KDM7A lysine (K)-specific demethylase 7A 0.167355
SPHKAP SPHK1 interactor, AKAP domain containing 0.166578
NEFL neurofilament, light polypeptide 0.166485
PLK3 polo-like kinase 3 0.165501
ORAI2 ORAI calcium release-activated calcium modulator 2 0.165469
TLL1 tolloid-like 1 0.164921
BICD1 bicaudal D homolog 1 (Drosophila) 0.163811
LPPR1 lipid phosphate phosphatase-related protein type 1 0.162423
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.160349
EML5 echinoderm microtubule associated protein like 5 0.15905
ESRRG estrogen-related receptor gamma 0.157935
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.155717
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.155607
HSPA4L heat shock 70kDa protein 4-like 0.155309
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.154557
ADAMTSL3 ADAMTS-like 3 0.154383
ST18 suppression of tumorigenicity 18, zinc finger 0.151861
HDAC9 histone deacetylase 9 0.151719
AHCYL2 adenosylhomocysteinase-like 2 0.150145
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.149403
ANKRD34C ankyrin repeat domain 34C 0.148504
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.148441
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.14622
PDZRN3 PDZ domain containing ring finger 3 0.145919
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.1428
NHLH2 nescient helix loop helix 2 0.140338
GADD45A growth arrest and DNA-damage-inducible, alpha 0.140071
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.14004
TMEM41A transmembrane protein 41A 0.136936
STAG3 stromal antigen 3 0.13222
KLF12 Kruppel-like factor 12 0.131515
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.130729
MMD2 monocyte to macrophage differentiation-associated 2 0.129363
EFR3B EFR3 homolog B (S. cerevisiae) 0.129269
IGSF21 immunoglobin superfamily, member 21 0.128831
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 0.128049
ZFPM2 zinc finger protein, FOG family member 2 0.127767
UBA1 ubiquitin-like modifier activating enzyme 1 0.125935
LTN1 listerin E3 ubiquitin protein ligase 1 0.124592
INSM1 insulinoma-associated 1 0.123579
LIMA1 LIM domain and actin binding 1 0.122361
PCDH11X protocadherin 11 X-linked 0.120944
TCHHL1 trichohyalin-like 1 0.117666
NEFM neurofilament, medium polypeptide 0.11666
ACVR1C activin A receptor, type IC 0.116537
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.114155
LMO2 LIM domain only 2 (rhombotin-like 1) 0.113847
TRAFD1 TRAF-type zinc finger domain containing 1 0.113122
MURC muscle-related coiled-coil protein 0.112645
CXXC5 CXXC finger protein 5 0.112415
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.109755
LAP3 leucine aminopeptidase 3 0.108224
OR6C2 olfactory receptor, family 6, subfamily C, member 2 0.107061
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.106496
KIAA1324L KIAA1324-like 0.106298
FAM212B family with sequence similarity 212, member B 0.10406
CSRP1 cysteine and glycine-rich protein 1 0.103391
NRP1 neuropilin 1 0.099986
AKNAD1 AKNA domain containing 1 0.099111
NEK6 NIMA-related kinase 6 0.098284
GOLIM4 golgi integral membrane protein 4 0.097383
MYO6 myosin VI 0.092557
MIR339 microRNA 339 0.090555
OXSR1 oxidative stress responsive 1 0.090555
SLAIN1 SLAIN motif family, member 1 0.088325
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.084411
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 0.082678
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 0.080606
TBC1D4 TBC1 domain family, member 4 0.07935
ADCY9 adenylate cyclase 9 0.076637
KCTD16 potassium channel tetramerization domain containing 16 0.072638
CPNE4 copine IV 0.071494
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 0.067972
MAML3 mastermind-like 3 (Drosophila) 0.065468
STXBP5L syntaxin binding protein 5-like 0.063879
SH3RF3 SH3 domain containing ring finger 3 0.063521
LONRF1 LON peptidase N-terminal domain and ring finger 1 0.061352
ELMOD2 ELMO/CED-12 domain containing 2 0.057315
GNG8 guanine nucleotide binding protein (G protein), gamma 8 0.051716
TOP1MT topoisomerase (DNA) I, mitochondrial 0.048434
MAST1 microtubule associated serine/threonine kinase 1 0.048121
TPRN taperin 0.047867
FLRT3 fibronectin leucine rich transmembrane protein 3 0.042396
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.041787
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.038812
KLC1 kinesin light chain 1 0.035953
CLOCK clock circadian regulator 0.035009
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.034308
EDN2 endothelin 2 0.033394
GSTM2 glutathione S-transferase mu 2 (muscle) 0.03049
ESYT2 extended synaptotagmin-like protein 2 0.026164
CXORF21 chromosome X open reading frame 21 0.024763
NEK11 NIMA-related kinase 11 0.023502
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.02322
ACACA acetyl-CoA carboxylase alpha 0.019481
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.015162
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.014695
COL16A1 collagen, type XVI, alpha 1 0.013539
SNX29 sorting nexin 29 0.013097
CADM3 cell adhesion molecule 3 0.01137
ZNF426 zinc finger protein 426 0.005966
DENND5B DENN/MADD domain containing 5B 0.00573
MAP7D2 MAP7 domain containing 2 0.002555
PLCD1 phospholipase C, delta 1 0.002392
LURAP1L leucine rich adaptor protein 1-like 0.002091
CRABP1 cellular retinoic acid binding protein 1 0.001471
AZI2 5-azacytidine induced 2 7.15E-4

decreased expression

Symbol Name Standardized Value
SORBS2 sorbin and SH3 domain containing 2 -1.14923
KIF26B kinesin family member 26B -1.14825
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -1.1478
PLXNA4 plexin A4 -1.14727
SSTR2 somatostatin receptor 2 -1.14599
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -1.14561
FAT3 FAT atypical cadherin 3 -1.14418
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -1.14395
EMCN endomucin -1.14066
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -1.13731
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 -1.13519
TTC28 tetratricopeptide repeat domain 28 -1.13324
BCL6 B-cell CLL/lymphoma 6 -1.12787
WNT7B wingless-type MMTV integration site family, member 7B -1.12512
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -1.12346
CDH8 cadherin 8, type 2 -1.12001
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -1.11532
STXBP2 syntaxin binding protein 2 -1.11142
CEMIP cell migration inducing protein, hyaluronan binding -1.10967
UNC5D unc-5 homolog D (C. elegans) -1.0969
GAB1 GRB2-associated binding protein 1 -1.09624
TBR1 T-box, brain, 1 -1.09516
ATXN7L1 ataxin 7-like 1 -1.09027
SLC30A10 solute carrier family 30, member 10 -1.08273
FRRS1L ferric-chelate reductase 1-like -1.07234
FAM84A family with sequence similarity 84, member A -1.06706
SMAD1 SMAD family member 1 -1.06381
CDK6 cyclin-dependent kinase 6 -1.06254
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 -1.06135
TENM4 teneurin transmembrane protein 4 -1.05312
ZBBX zinc finger, B-box domain containing -1.04643
BEND5 BEN domain containing 5 -1.03998
DUSP14 dual specificity phosphatase 14 -1.02769
SATB2 SATB homeobox 2 -1.01977
LYPD6 LY6/PLAUR domain containing 6 -1.01446
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.983971
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -0.981595
NTNG2 netrin G2 -0.976563
TMEM44 transmembrane protein 44 -0.975994
KIZ kizuna centrosomal protein -0.97093
CXCL12 chemokine (C-X-C motif) ligand 12 -0.970106
NECAB3 N-terminal EF-hand calcium binding protein 3 -0.967327
PTCHD2 patched domain containing 2 -0.96695
PC pyruvate carboxylase -0.966259
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.936206
CARTPT CART prepropeptide -0.9288
LRRN3 leucine rich repeat neuronal 3 -0.927733
ADC -0.916574
TSPAN7 tetraspanin 7 -0.915527
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -0.910463
HPCA hippocalcin -0.901319
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -0.896706
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.893023
FGF8 fibroblast growth factor 8 (androgen-induced) -0.882906
WDR62 WD repeat domain 62 -0.849827
MIR708 microRNA 708 -0.837735
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit -0.820463
TFF1 trefoil factor 1 -0.816001
SLC35B1 solute carrier family 35, member B1 -0.804543
ADARB1 adenosine deaminase, RNA-specific, B1 -0.800987
MIR137 microRNA 137 -0.797223
NUP210L nucleoporin 210kDa-like -0.776831
GLIS1 GLIS family zinc finger 1 -0.77583
EFNB2 ephrin-B2 -0.748405
SHISA5 shisa family member 5 -0.747463
ZDHHC18 zinc finger, DHHC-type containing 18 -0.725895
ULK1 unc-51 like autophagy activating kinase 1 -0.719195
LPP LIM domain containing preferred translocation partner in lipoma -0.714022
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase -0.703291
SP6 Sp6 transcription factor -0.702867
TTC7A tetratricopeptide repeat domain 7A -0.696724
NGB neuroglobin -0.694797
DHRS11 dehydrogenase/reductase (SDR family) member 11 -0.689335
THUMPD1 THUMP domain containing 1 -0.688926
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 -0.674896
PNKD paroxysmal nonkinesigenic dyskinesia -0.66799
ZNF770 zinc finger protein 770 -0.664289
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.646117
WBSCR17 Williams-Beuren syndrome chromosome region 17 -0.633685
SIK2 salt-inducible kinase 2 -0.632165
LZTS1 leucine zipper, putative tumor suppressor 1 -0.625335
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -0.622983
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.613791
C1QTNF2 C1q and tumor necrosis factor related protein 2 -0.61262
CPLX2 complexin 2 -0.61145
TMEM17 transmembrane protein 17 -0.604353
MAP2K6 mitogen-activated protein kinase kinase 6 -0.601963
FSD2 fibronectin type III and SPRY domain containing 2 -0.595575
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -0.589497
CAMK4 calcium/calmodulin-dependent protein kinase IV -0.586157
C14ORF1 chromosome 14 open reading frame 1 -0.575774
FCHSD1 FCH and double SH3 domains 1 -0.5731
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.572422
C3ORF58 chromosome 3 open reading frame 58 -0.567051
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -0.566053
TMEM50B transmembrane protein 50B -0.565777
PLBD1 phospholipase B domain containing 1 -0.559134
PCDHB5 protocadherin beta 5 -0.540902
SST somatostatin -0.536756
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 -0.535433
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) -0.533786
CYYR1 cysteine/tyrosine-rich 1 -0.527403
SH3BP2 SH3-domain binding protein 2 -0.526091
GPR176 G protein-coupled receptor 176 -0.520699
ETV1 ets variant 1 -0.520425
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.519244
ACKR3 atypical chemokine receptor 3 -0.514691
VRK2 vaccinia related kinase 2 -0.514512
FGF21 fibroblast growth factor 21 -0.513676
HUNK hormonally up-regulated Neu-associated kinase -0.505256
OSBPL10 oxysterol binding protein-like 10 -0.502878
EPHA3 EPH receptor A3 -0.500073
MYO18B myosin XVIIIB -0.497929
PHF21B PHD finger protein 21B -0.49584
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.490966
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) -0.487449
ZNF846 zinc finger protein 846 -0.479882
CLK3 CDC-like kinase 3 -0.478765
EPHA7 EPH receptor A7 -0.476855
PPP2R1B protein phosphatase 2, regulatory subunit A, beta -0.473374
SBK2 SH3 domain binding kinase family, member 2 -0.47058
MIR34A microRNA 34a -0.460948
NXF2 nuclear RNA export factor 2 -0.460824
RAB33A RAB33A, member RAS oncogene family -0.454056
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -0.452688
KLHL29 kelch-like family member 29 -0.451382
OR52D1 olfactory receptor, family 52, subfamily D, member 1 -0.450901
NIPAL4 NIPA-like domain containing 4 -0.449356
CLCNKB chloride channel, voltage-sensitive Kb -0.448723
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -0.44111
PRKCD protein kinase C, delta -0.440829
GPR171 G protein-coupled receptor 171 -0.434646
ECT2L epithelial cell transforming 2 like -0.432364
SPAG11A sperm associated antigen 11A -0.429346
PODXL2 podocalyxin-like 2 -0.428856
SHB Src homology 2 domain containing adaptor protein B -0.428474
POGZ pogo transposable element with ZNF domain -0.425212
LASP1 LIM and SH3 protein 1 -0.424545
FAM168A family with sequence similarity 168, member A -0.422857
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -0.421503
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -0.417868
MRPL47 mitochondrial ribosomal protein L47 -0.417181
ICOS inducible T-cell co-stimulator -0.417081
TLE3 transducin-like enhancer of split 3 -0.416404
PDE1B phosphodiesterase 1B, calmodulin-dependent -0.078333
DTNA dystrobrevin, alpha -0.078242
HPDL 4-hydroxyphenylpyruvate dioxygenase-like -0.077575
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -0.076413
SUGP2 SURP and G patch domain containing 2 -0.075609
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.075377
RAB6A RAB6A, member RAS oncogene family -0.074367
MICU1 mitochondrial calcium uptake 1 -0.074083
GRIK2 glutamate receptor, ionotropic, kainate 2 -0.073736
GMIP GEM interacting protein -0.07292
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) -0.069369
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III -0.067107
ZP3 zona pellucida glycoprotein 3 (sperm receptor) -0.064084
DHRS7B dehydrogenase/reductase (SDR family) member 7B -0.062155
NELL2 NEL-like 2 (chicken) -0.061996
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.06077
RALGDS ral guanine nucleotide dissociation stimulator -0.060537
DENND1B DENN/MADD domain containing 1B -0.059961
ZIC5 Zic family member 5 -0.059448
MYO19 myosin XIX -0.058057
CSDC2 cold shock domain containing C2, RNA binding -0.054809
SYT11 synaptotagmin XI -0.052565
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) -0.049299
VCAM1 vascular cell adhesion molecule 1 -0.047999
TCF4 transcription factor 4 -0.046596
SIRT1 sirtuin 1 -0.046397
PRF1 perforin 1 (pore forming protein) -0.046237
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -0.042503
ABHD17A abhydrolase domain containing 17A -0.040768
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.039992
CSMD3 CUB and Sushi multiple domains 3 -0.036157
DNAH9 dynein, axonemal, heavy chain 9 -0.03505
NT5DC3 5'-nucleotidase domain containing 3 -0.034839
MMP13 matrix metallopeptidase 13 -0.03467
MIR381 microRNA 381 -0.034333
ZNF667 zinc finger protein 667 -0.033997
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.033744
THRB thyroid hormone receptor, beta -0.032073
MFGE8 milk fat globule-EGF factor 8 protein -0.030843
CDH23 cadherin-related 23 -0.029195
KIF21A kinesin family member 21A -0.028981
NRXN1 neurexin 1 -0.023792
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 -0.02235
GADD45G growth arrest and DNA-damage-inducible, gamma -0.019539
TH tyrosine hydroxylase -0.016643
DUSP4 dual specificity phosphatase 4 -0.016266
TGS1 trimethylguanosine synthase 1 -0.010233
THSD7A thrombospondin, type I, domain containing 7A -0.010211
CERS5 ceramide synthase 5 -0.009108
NPC1 Niemann-Pick disease, type C1 -0.009017
ELP4 elongator acetyltransferase complex subunit 4 -0.007281
PON3 paraoxonase 3 -0.004861
UNCX UNC homeobox -0.004293
NAP1L2 nucleosome assembly protein 1-like 2 -0.003726
USP24 ubiquitin specific peptidase 24 -0.003636
C2ORF72 chromosome 2 open reading frame 72 -0.003568
STAC2 SH3 and cysteine rich domain 2 -0.002294
SPEF2 sperm flagellar 2 -0.002294
GOLGA4 golgin A4 -0.001248
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.01E-4
OLFM2 olfactomedin 2 -1.09E-4
Funding