epidermal growth factor receptor signaling pathway Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. (Gene Ontology, GO_0007173)
External Link http://amigo.geneontology.org/amigo/term/GO:0007173
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Genes

50 genes participating in the epidermal growth factor receptor signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
AREG amphiregulin
BCAR1 breast cancer anti-estrogen resistance 1
BCAR3 breast cancer anti-estrogen resistance 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTC betacellulin
CRIPTO3 cripto, EGF-CFC family member 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPGN epithelial mitogen
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERBIN erbb2 interacting protein
EREG epiregulin
FAM83A family with sequence similarity 83, member A
GAREM1 GRB2 associated regulator of MAPK1 subtype 1
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
HBEGF heparin-binding EGF-like growth factor
HDAC6 histone deacetylase 6
IQGAP1 IQ motif containing GTPase activating protein 1
KIF16B kinesin family member 16B
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
NCK2 NCK adaptor protein 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PIGR polymeric immunoglobulin receptor
PIGU phosphatidylinositol glycan anchor biosynthesis, class U
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCE1 phospholipase C, epsilon 1
PLCG1 phospholipase C, gamma 1
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
REPS2 RALBP1 associated Eps domain containing 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC30A10 solute carrier family 30, member 10
SOS1 son of sevenless homolog 1 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TGFA transforming growth factor, alpha
VIL1 villin 1